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Keywords: Brachyury
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Journal Articles
Journal: Development
Development (2022) 149 (10): dev200252.
Published: 16 May 2022
... . EvoDevo 6 , 30 . 10.1186/s13227-015-0025-3 Artinger , M. , Blitz , I. , Inoue , K. , Tran , U. and Cho , K. W. ( 1997 ). Interaction of goosecoid and brachyury in Xenopus mesoderm patterning . Mech. Dev. 65 , 187 - 196 . 10.1016/S0925-4773(97)00073-7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev200059.
Published: 15 December 2021
... is the prime organizing center for axial elongation in mouse embryos. The T-box transcription factor brachyury (T) is essential for both formation of the notochord and maintenance of NMPs, and thus is a key regulator of trunk and tail development. The T promoter controlling T expression in NMPs and nascent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199408.
Published: 1 June 2021
... between Wnt and Brachyury/Tbxt is required for NMps to retain mesodermal potential and, hence, normal axis development. We recently showed that Hox13 genes help to support body axis formation and to maintain the autoregulatory loop, although the direct Hox13 target genes were unknown. Here, using a new...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev195230.
Published: 5 February 2021
...Wendy M. Reeves; Kotaro Shimai; Konner M. Winkley; Michael T. Veeman ABSTRACT The notochord is a defining feature of the chordates. The transcription factor Brachyury (Bra) is a key regulator of notochord fate but here we show that it is not a unitary master regulator in the model chordate Ciona...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev185298.
Published: 27 November 2020
... Brachyury to allow mesoderm formation. Mutants lacking both hoxa13b and hoxd13a in combination with reduced Brachyury activity have synergistic posterior body defects, in the strongest case producing embryos with severe mesodermal defects that phenocopy brachyury null mutants. Our results provide a new way...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev188094.
Published: 11 September 2020
... Dishevelled . Nat. Commun.   6 , 8388 . 10.1038/ncomms9388 Smith , J. C. , Price , B. M. J. , Green , J. B. A. , Weigel , D. and Herrmann , B. G. ( 1991 ). Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction . Cell   67 , 79...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev189324.
Published: 27 May 2020
..., suggesting that Rspo2 functions upstream of Mek1. The observed inhibition of FGF signaling was accompanied by the downregulation of the FGF target genes tbxt/brachyury and cdx4 , which mediate anterioposterior axis specification. Importantly, these target genes were upregulated in Rspo2-depleted explants...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev181917.
Published: 15 October 2019
..., are hard to tease apart in vivo . Using brachyury (Bra), a primitive streak and mesendoderm marker in mouse embryoid bodies (EBs), we studied how contact, biochemical cues and neighboring cell cues affect the positioning of a primitive streak-like locus and thus determine the anteroposterior axis. We show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev155879.
Published: 29 January 2018
... and other genes (brachyury, Sox1 and Pmx1 ) in various mutant mouse embryos until the adult stage. This tracing of MSC origins and destinies indicates that embryonic MSCs emerge in waves and that almost all adult BM MSCs and WAT MSCs originate from mesoderm and embryonic Pdgfrα-positive cells. Furthermore...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2951–2960.
Published: 15 August 2017
...Marc D. Servetnick; Bailey Steinworth; Leslie S. Babonis; David Simmons; Miguel Salinas-Saavedra; Mark Q. Martindale ABSTRACT The mesoderm is a key novelty in animal evolution, although we understand little of how the mesoderm arose. brachyury , the founding member of the T-box gene family...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1628–1638.
Published: 1 May 2015
... progenitors towards a paraxial mesodermal fate. Neural progenitor Neuromesodermal progenitor Wnt signaling Brachyury Paraxial mesoderm Sox2 To show that the observed change of fate from mesoderm to neural is unique to PS cells, we also examined the Shh-Cre traced gut and notochord...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3649–3661.
Published: 1 October 2014
.... The latter process depends on Xenopus Brachyury, the expression of which at the time of peak involution is controlled by signaling through the ephrin receptor, EphA4, its ligand ephrinB2 and its downstream effector p21-activated kinase. Our findings support a conserved role for Brachyury in blastopore...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (11): 2422–2433.
Published: 1 June 2013
...Diana S. José-Edwards; Izumi Oda-Ishii; Yutaka Nibu; Anna Di Gregorio T-box genes are potent regulators of mesoderm development in many metazoans. In chordate embryos, the T-box transcription factor Brachyury (Bra) is required for specification and differentiation of the notochord. In some...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (24): 4099–4110.
Published: 15 December 2009
... Cdx Vertebral patterning Axis elongation Brachyury Wnt3a Retinoic acid CYP26a1 Mouse Wholemount immunohistochemistry was performed as previously described ( Savory et al., 2009 ). For in situ hybridization and immunohistochemistry, embryos to be compared were processed in parallel...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (21): 3679–3689.
Published: 1 November 2009
...Yale J. Passamaneck; Lavanya Katikala; Lorena Perrone; Matthew P. Dunn; Izumi Oda-Ishii; Anna Di Gregorio The notochord is a defining feature of the chordate body plan. Experiments in ascidian, frog and mouse embryos have shown that co-expression of Brachyury and FoxA class transcription factors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (6): 1029–1038.
Published: 15 March 2009
... a clear sequence of events occurring in the process of germ-layer formation, using immunohistochemistry and time-lapse confocal imaging. The T-box transcription factor brachyury (T) and the Forkhead transcription factor Foxa2 specify mesoderm and endoderm in the posterior epiblast. Fate-specified epiblast...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4187–4197.
Published: 1 December 2007
...Holger Bielen; Sabine Oberleitner; Sylvain Marcellini; Lydia Gee; Patrick Lemaire; Hans R. Bode; Ralph Rupp; Ulrich Technau Homologues of the T-box gene Brachyury play important roles in mesoderm differentiation and other aspects of early development in all bilaterians. In the diploblast Hydra...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2947–2959.
Published: 1 August 2006
...Kimberly E. Inman; Karen M. Downs Mouse conceptuses homozygous for mutations in brachyury ( T )exhibit a short, misshapen allantois that fails to fuse with the chorion. Ultimately, mutant embryos die during mid-gestation. In the 60 years since this discovery, the role of T in allantoic development...
Journal Articles
Journal: Development
Development (2004) 131 (6): 1279–1288.
Published: 15 March 2004
...Kasumi Yagi; Yutaka Satou; Nori Satoh In ascidian embryos, Brachyury is expressed exclusively in blastomeres of the notochord lineage and play an essential role in the notochord cell differentiation. The genetic cascade leading to the transcriptional activation of Brachyury in A-line notochord...
Journal Articles
Journal: Development
Development (2003) 130 (17): 4217–4227.
Published: 1 September 2003
... the developmental processes that regulate mesoderm induction and specification to the hemangioblast, we generated an embryonic stem cell line with the green fluorescent protein (GFP) targeted to the mesodermal gene, brachyury. After the in vitro differentiation of these embryonic stem cells to embryoid bodies...