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Keywords: Bone
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Journal Articles
Journal: Development
Development (2022) 149 (5): dev199995.
Published: 11 March 2022
... diseases is treated using bone-grafting techniques that suffer from numerous shortcomings and contraindications. Zebrafish naturally heal large injuries to mandibular bone, offering an opportunity to understand how to boost intrinsic healing potential. Using a novel her6:mCherry Notch reporter, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200172.
Published: 7 February 2022
...Rosalind G. Bump; Camille E. A. Goo; Emma C. Horton; Jeffrey P. Rasmussen ABSTRACT Skeletal elements frequently associate with vasculature and somatosensory nerves, which regulate bone development and homeostasis. However, the deep, internal location of bones in many vertebrates has limited in vivo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev197483.
Published: 15 April 2021
...Jennyfer M. Mitchell; Juliana Sucharov; Anthony T. Pulvino; Elliott P. Brooks; Austin E. Gillen; James T. Nichols ABSTRACT During craniofacial development, different populations of cartilage- and bone-forming cells develop in precise locations in the head. Most of these cells are derived from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev181834.
Published: 22 January 2020
... development and throughout adulthood. Zebrafish have both mononucleated and multinucleated osteoclasts that participate in normal bone remodeling ( Witten et al., 2001 ; Witten and Huysseune, 2009 ). Mononucleated osteoclasts are numerous and participate in laminar bone resorption without the presence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev148296.
Published: 5 September 2019
... mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. Bone Development Hematopoiesis RUNX T cell Embryonic The RUNX family of transcription factors orchestrate various developmental and cellular processes, such as cell...
Journal Articles
Journal: Development
Development (2018) 145 (12): dev165498.
Published: 26 June 2018
...Pengfei Xu; Bartosz Balczerski; Amanda Ciozda; Kristin Louie; Veronika Oralova; Ann Huysseune; J. Gage Crump ABSTRACT Facial form depends on the precise positioning of cartilage, bone, and tooth fields in the embryonic pharyngeal arches. How complex signaling information is integrated to specify...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2994–3005.
Published: 15 August 2017
... . 10.1006/dbio.1998.9016 Kimmel , C. B. , Ullmann , B. , Walker , M. , Miller , C. T. and Crump , J. G. ( 2003 ). Endothelin 1-mediated regulation of pharyngeal bone development in zebrafish . Development   130 , 1339 - 1351 . 10.1242/dev.00338 Kurihara , Y...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (23): 4430–4440.
Published: 1 December 2016
... hypothetical mechanism accounting for mutant phenotypic variation is progenitor cells variably choosing between two alternative fates during development. Zebrafish mef2ca b1086 mutants develop tremendously variable ectopic bone in their hyoid craniofacial skeleton. Here, we report evidence that a key component...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (15): 2706–2715.
Published: 1 August 2016
...Kishor K. Sivaraj; Ralf H. Adams In addition to their conventional role as a conduit system for gases, nutrients, waste products or cells, blood vessels in the skeletal system play active roles in controlling multiple aspects of bone formation and provide niches for hematopoietic stem cells...
Journal Articles
Journal: Development
Development (2015) 142 (17): 2894–2903.
Published: 1 September 2015
... of proliferation, preosteoblasts redifferentiate to produce new bone. Blastema formation and proliferation are driven by the continued synthesis of retinoic acid (RA). Here, we find that osteoblast dedifferentiation and redifferentiation are inhibited by RA signaling, and we uncover how the bone regenerative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1733–1744.
Published: 15 May 2015
... remains to be understood about vertebral development and evolution. Particular controversy surrounds whether vertebral component structures are homologous across vertebrates, how somite and vertebral patterning are connected, and the developmental origin of vertebral bone-mineralizing cells. Here, we...
Journal Articles
Journal: Development
Development (2015) 142 (6): 1023–1027.
Published: 15 March 2015
...Paolo Bianco; Pamela G. Robey Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal...
Journal Articles
Journal: Development
Development (2014) 141 (11): 2225–2234.
Published: 1 June 2014
...Karina Geurtzen; Franziska Knopf; Daniel Wehner; Leonie F. A. Huitema; Stefan Schulte-Merker; Gilbert Weidinger Zebrafish have an unlimited capacity to regenerate bone after fin amputation. In this process, mature osteoblasts dedifferentiate to osteogenic precursor cells and thus represent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 2855–2859.
Published: 15 July 2011
...Gabrielle Kardon In March 2011, researchers met for the second Batsheva Seminar on Integrative Perspectives on the Development of the Musculoskeletal System. This meeting was a unique opportunity for researchers working on muscle, connective tissue, tendons, ligaments and bone to discuss...
Journal Articles
Journal: Development
Development (2010) 137 (3): 389–394.
Published: 1 February 2010
... to direct adipocyte differentiation at the expense of osteoblast formation. In addition, we identify two distinct roles for RA in the osteoblast lineage: an early role in blocking the recruitment of osteoblasts and a later role in mature osteoblasts to promote bone matrix synthesis. These findings might...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (24): 4177–4185.
Published: 15 December 2009
...Kyu Sang Joeng; Fanxin Long Indian hedgehog (Ihh) critically regulates multiple aspects of endochondral bone development. Although it is generally believed that all Ihh functions are mediated by the Gli family of transcription activators and repressors, formal genetic proof for this notion has...
Journal Articles
Journal: Development
Development (2008) 135 (22): 3775–3787.
Published: 15 November 2008
...Kathrin Laue; Martina Jänicke; Nikki Plaster; Carmen Sonntag; Matthias Hammerschmidt Skeletal syndromes are among the most common birth defects. Vertebrate skeletogenesis involves two major cell types: cartilage-forming chondrocytes and bone-forming osteoblasts. In vitro, both are under...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (23): 5249–5260.
Published: 1 December 2005
... affected ( Hui and Joyner,1993 ; Mo et al.,1997 ; Park et al.,2000 ; Schimmang et al.,1992 ). Whereas no bone phenotype has been detected in Gli1 –/– mutants, loss of Gli2 or Gli3 results in a slight reduction in bone length. Analysis of Gli2 –/– ,Gli3 +/– compound mutants revealed a more...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (19): 4339–4351.
Published: 1 October 2005
... skeleton, but also identify an osteogenic role for a vasculature-derived signal, which integrates with Ihh and Wnt signals to determine the osteoblast versus chondrocyte fate in the mesenchymal progenitors. Examination of the whole-mount stained skeletons at E18.5 also revealed that the bone collar...
Journal Articles
Journal: Development
Development (2005) 132 (15): 3537–3548.
Published: 1 August 2005
..., and cartilage abnormalities in the basicranium, nasal turbinates and trachea. In addition, from the mutant long bones, in vitro cell cultures grown in osteogenic medium revealed chondrocytes, which were absent in the controls. Our results suggest that altered cartilage and bone development play a significant...
Includes: Supplementary data