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Keywords: Body size
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Journal Articles
Journal: Development
Development (2021) 148 (5): dev196949.
Published: 05 March 2021
..., the position of QR descendants depends on body size, which we varied by changing maternal age or using body size mutants. Using a mathematical model, we show that body size variation is partially compensated for. Applying environmental perturbations, we find that the variance in final position increased...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (7): dev184044.
Published: 08 April 2020
...Eudald Pascual-Carreras; Marta Marin-Barba; Carlos Herrera-Úbeda; Daniel Font-Martín; Kay Eckelt; Nidia de Sousa; Jordi García-Fernández; Emili Saló; Teresa Adell ABSTRACT Control of cell number is crucial to define body size during animal development and to restrict tumoral transformation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev161356.
Published: 11 June 2018
...Sarah D. Neuman; Arash Bashirullah ABSTRACT All animals must coordinate growth rate and timing of maturation to reach the appropriate final size. Here, we describe hobbit , a novel and conserved gene identified in a forward genetic screen for Drosophila animals with small body size. hobbit...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2375–2384.
Published: 15 July 2010
... molecule (RGM) family of proteins in C. elegans , and is crucial in regulating body size and mesoderm development. Using a combination of molecular genetic and biochemical analyses, we demonstrate that DRAG-1 is a membrane-associated protein that functions at the ligand-receptor level to modulate the Sma...
Journal Articles
Journal: Development
Development (2009) 136 (6): 983–993.
Published: 15 March 2009
... expression and dMyc transcriptional activity. Thus, maximal dMyc transcriptional activity depends on InR to control muscle mass, which in turn induces a systemic behavioral response to allocate body size and proportions. References Accili, D. and Arden, K. C. ( 2004 ). FoxOs at the crossroads...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (21): 4801–4810.
Published: 01 November 2005
... for generating different body sizes in the sexes; in Drosophila , females are larger and this difference is controlled by Sxl . Consistent with this proposal, discs expressing ectopic Sxl show an increase in growth. In keeping with the idea of the involvement of a signaling system, this growth effect by Sxl...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (15): 3505–3513.
Published: 01 August 2005
...Jianjun Wang; William A. Mohler; Cathy Savage-Dunn TGF-β signaling in the nematode Caenorhabditis elegans plays multiple roles in the development of the animal. The Sma/Mab pathway controls body size, male tail sensory ray identity and spicule formation. Three Smad genes, sma-2 , sma-3 and sma-4...
Journal Articles
Journal: Development
Development (2005) 132 (14): 3175–3184.
Published: 15 July 2005
...Naoharu Watanabe; Yasuko Nagamatsu; Keiko Gengyo-Ando; Shohei Mitani; Yasumi Ohshima We have analyzed the sma-5(n678) mutant in C. elegans to elucidate mechanisms controlling body size. The sma-5 mutant is very small, grows slowly and its intestinal granules look abnormal. We found a 15 kb deletion...
Journal Articles
Journal: Development
Development (2003) 130 (26): 6453–6464.
Published: 29 December 2003
...Jun Liang; Robyn Lints; Marisa L. Foehr; Rafal Tokarz; Ling Yu; Scott W. Emmons; Jun Liu; Cathy Savage-Dunn In Caenorhabditis elegans , the DBL-1 pathway, a BMP/TGFβ-related signaling cascade, regulates body size and male tail development. We have cloned a new gene, sma-9 , that encodes the C...
Journal Articles
Journal: Development
Development (2003) 130 (6): 1089–1099.
Published: 15 March 2003
..., whereas cell numbers are not. Experiments on genetic interaction suggest that the cGMP-EGL-4 signaling pathway represses body size and lifespan through DBL-1/TGF-β and insulin pathways, respectively. ‡ Author for correspondence (e-mail: yohshscb@mbox.nc.kyushu-u.ac.jp ) 6 12 2002 ©...
Journal Articles
Journal: Development
Development (2002) 129 (21): 4989–4998.
Published: 01 November 2002
...Jianjun Wang; Rafal Tokarz; Cathy Savage-Dunn In C. elegans , a TGFβ-related signaling pathway regulates body size. Loss of function of the signaling ligand ( dbl-1 ),receptors ( daf-4 and sma-6 ) or Smads ( sma-2, sma-3 and sma-4 ) results in viable, but smaller animals because of a reduction...