... in human kidneys ranges from several hundred thousand to nearly a million, and low nephron number has been implicated as a risk factor for kidney disease as an adult. Bmp7 is among a small number of growth factors required to support the proliferation and self-renewal of nephron progenitor cells...

... this endogenous regeneration model in neonatal mice, we have found that noggin treatment inhibits regeneration, thus suggesting a bone morphogenetic protein (BMP) requirement. Using non-regenerating amputation wounds, we show that BMP7 or BMP2 can induce a regenerative response. BMP-induced regeneration involves...

... activation,and inhibition of ERK1/2 activation blocked seminal vesicle branching morphogenesis. Partial loss of FGFR2(IIIb) was also associated with down-regulation of several branching morphogenesis regulators including Shh, Ptch1, Gli1, Gli2, Bmp4 , and Bmp7 . Together with previous studies, these data...

..., WC1E 6BT, UK 25 5 2006 © 2006. 2006 Isthmic organizer Mid/hindbrain organizer Roof plate FGF8 Follistatin Activin BMP7 GDF7 Chick Quail The roof plate (RP) is a specialized structure that extends on the dorsal midline of the neural tube along its entire...

... state of myoblasts, suppressing their differentiation, while a further branchial arch derived signal, namely Bmp7, is an overall negative regulator of head myogenesis. Fertilised hens' and quails' eggs were obtained from Winter Farm (Royston)and Potter Farm (Woodhurst), and incubated at 38.5°C...

... formation develops normally. The N-terminally truncated isoform of p63(ΔNp63) was expressed at high levels in embryonic ectoderm at all stages of tooth and hair development, and it was already dominant over the transactivating TAp63 isoform prior to epidermal stratification. Bmp7,Fgfr2b, Jag1 and Notch1...

...Kyoji Ohyama; Pamela Ellis; Shioko Kimura; Marysia Placzek Hypothalamic neurons play a key role in homeostasis, yet little is known about their differentiation. Here, we demonstrate that Shh and Bmp7 from the adjacent prechordal mesoderm govern hypothalamic neural fate, their sequential action...

... Bmp2 and Bmp7 expression in Hoxa13 mutant limbs. Biochemical analyses identified a novel series of Bmp2 and Bmp7 enhancer regions that directly interact with the HOXA13 DNA-binding domain and activate gene expression in the presence of HOXA13. Immunoprecipitation of HOXA13- Bmp2 and HOXA13- Bmp7...

.... Riboprobes for chicken Bmp2, Bmp4, Bmp7 ( Chang et al., 2002 ), SOHo-1 ( Kiernan,1997 ), Fibroblast growth factor receptor 1-3 ( Fgfr ) ( Walshe and Mason,2000 ), Fgf10 ( Ohuchi et al., 1997 ) and Fgf3 ( Mahmood et al., 1995 ) were also prepared according to procedures described in the cited...

... of noradrenergic gene expression in the autonomic nervous system. * Author for correspondence (e-mail: rohrer@mpih-frankfurt.mpg.de ) 29 8 2002 ©2002. 2002 Ciliary Cholinergic Noradrenergic dHand BMP5 BMP7 Autonomic nervous system The developing peripheral nervous system...

... SU5402 treatment. FGFR1 signaling regulates Fgfr1, Fgf1, Fgf3 and Bmp7 expression and indirectly regulates Fgf7, Fgf10 and Bmp4 . Exogenous FGFs and BMPs added to glands in culture reveal distinct effects on gland morphology. Glands cultured with SU5402 were then rescued with exogenous BMP7, FGF7...

... in failure in formation of the ciliary processes. Co-expression of transgenic BMP7 restores normal development of the ciliary epithelium. Ectopic expression of Noggin also promotes differentiation of retinal ganglion cells. These results indicate that BMP signaling is required for development of the ciliary...

... exclusively in the presumptive lens ectoderm showed defects in formation of the lens placode at E9.5 but in addition, showed reduced levels of expression for Pax6 , Sox2 and Foxe3 , all markers of lens induction; (3) by performing crosses between Tfr7 transgenic and Bmp7 -null mice, we showed...

... in laf m100 , Alk8 is prematurely terminated directly after the transmembrane domain. The zygotic effect of both mutations leads to dorsalization of intermediate strength. A much stronger dorsalization, similar to that of bmp2b / swirl and bmp7 / snailhouse mutants, however, is obtained by inhibiting...

..., snailhouse/bmp7 and somitabun/smad5 . We demonstrate that Bmp signaling is essential for the establishment of the prospective neural crest and dorsal sensory Rohon-Beard neurons of the spinal cord. Moreover, Bmp signaling is necessary to limit the number of intermediate-positioned lim1 + interneurons...

... requirement for two different Bmp ligand subclass genes for dorsoventral pattern formation of the zebrafish embryo. From the relative efficiencies observed in Bmp ligand rescue experiments, conserved chromosomal synteny, and isolation of the zebrafish bmp7 gene, we determined that the strongly dorsalized...

... here that zebrafish Bmp7 is disrupted in snailhouse ( snh ) mutants. The allele snh st1 is a translocation deleting the bmp7 gene, while snh ty68 displays a Val→Gly exhange in a conserved motif of the Bmp7 prodomain. The snh ty68 mutation is temperature-sensitive, leading to severalfold reduced...

... the signalling molecule Bmp7 as the mediator of this inductive interaction. This molecule is expressed in a manner consistent with it playing such a role and, when added to ectoderm explants, it will promote the formation of epibranchial neuronal cells. Moreover, the Bmp7 antagonist follstatin will block...

... by sonic hedgehog (SHH) secreted from the notochord whereas ventral midline cells of the rostral diencephalon (RDVM cells) appear to be induced by the dual actions of SHH and bone morphogenetic protein 7 (BMP7) from prechordal mesoderm. We have examined the cellular and molecular events that govern...