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Keywords: Bmp7
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Journal Articles
Journal: Development
Development (2022) 149 (14): dev200773.
Published: 25 July 2022
... in human kidneys ranges from several hundred thousand to nearly a million, and low nephron number has been implicated as a risk factor for kidney disease as an adult. Bmp7 is among a small number of growth factors required to support the proliferation and self-renewal of nephron progenitor cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (4): 551–559.
Published: 15 February 2010
... this endogenous regeneration model in neonatal mice, we have found that noggin treatment inhibits regeneration, thus suggesting a bone morphogenetic protein (BMP) requirement. Using non-regenerating amputation wounds, we show that BMP7 or BMP2 can induce a regenerative response. BMP-induced regeneration involves...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (3): 557–565.
Published: 1 February 2007
... activation,and inhibition of ERK1/2 activation blocked seminal vesicle branching morphogenesis. Partial loss of FGFR2(IIIb) was also associated with down-regulation of several branching morphogenesis regulators including Shh, Ptch1, Gli1, Gli2, Bmp4 , and Bmp7 . Together with previous studies, these data...
Journal Articles
Journal: Development
Development (2006) 133 (15): 2905–2913.
Published: 1 August 2006
..., WC1E 6BT, UK 25 5 2006 © 2006. 2006 Isthmic organizer Mid/hindbrain organizer Roof plate FGF8 Follistatin Activin BMP7 GDF7 Chick Quail The roof plate (RP) is a specialized structure that extends on the dorsal midline of the neural tube along its entire...
Journal Articles
Journal: Development
Development (2006) 133 (14): 2731–2745.
Published: 15 July 2006
... state of myoblasts, suppressing their differentiation, while a further branchial arch derived signal, namely Bmp7, is an overall negative regulator of head myogenesis. Fertilised hens' and quails' eggs were obtained from Winter Farm (Royston)and Potter Farm (Woodhurst), and incubated at 38.5°C...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (8): 1553–1563.
Published: 15 April 2006
... formation develops normally. The N-terminally truncated isoform of p63(ΔNp63) was expressed at high levels in embryonic ectoderm at all stages of tooth and hair development, and it was already dominant over the transactivating TAp63 isoform prior to epidermal stratification. Bmp7,Fgfr2b, Jag1 and Notch1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (23): 5185–5197.
Published: 1 December 2005
...Kyoji Ohyama; Pamela Ellis; Shioko Kimura; Marysia Placzek Hypothalamic neurons play a key role in homeostasis, yet little is known about their differentiation. Here, we demonstrate that Shh and Bmp7 from the adjacent prechordal mesoderm govern hypothalamic neural fate, their sequential action...
Journal Articles
Journal: Development
Development (2004) 131 (18): 4581–4592.
Published: 15 September 2004
... Bmp2 and Bmp7 expression in Hoxa13 mutant limbs. Biochemical analyses identified a novel series of Bmp2 and Bmp7 enhancer regions that directly interact with the HOXA13 DNA-binding domain and activate gene expression in the presence of HOXA13. Immunoprecipitation of HOXA13- Bmp2 and HOXA13- Bmp7...
Journal Articles
Journal: Development
Development (2004) 131 (17): 4201–4211.
Published: 1 September 2004
.... Riboprobes for chicken Bmp2, Bmp4, Bmp7 ( Chang et al., 2002 ), SOHo-1 ( Kiernan,1997 ), Fibroblast growth factor receptor 1-3 ( Fgfr ) ( Walshe and Mason,2000 ), Fgf10 ( Ohuchi et al., 1997 ) and Fgf3 ( Mahmood et al., 1995 ) were also prepared according to procedures described in the cited...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2002) 129 (19): 4435–4442.
Published: 1 October 2002
... in failure in formation of the ciliary processes. Co-expression of transgenic BMP7 restores normal development of the ciliary epithelium. Ectopic expression of Noggin also promotes differentiation of retinal ganglion cells. These results indicate that BMP signaling is required for development of the ciliary...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4425–4438.
Published: 15 November 2001
... exclusively in the presumptive lens ectoderm showed defects in formation of the lens placode at E9.5 but in addition, showed reduced levels of expression for Pax6 , Sox2 and Foxe3 , all markers of lens induction; (3) by performing crosses between Tfr7 transgenic and Bmp7 -null mice, we showed...
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (6): 1209–1220.
Published: 15 March 2000
..., snailhouse/bmp7 and somitabun/smad5 . We demonstrate that Bmp signaling is essential for the establishment of the prospective neural crest and dorsal sensory Rohon-Beard neurons of the spinal cord. Moreover, Bmp signaling is necessary to limit the number of intermediate-positioned lim1 + interneurons...
Journal Articles
Journal: Development
Development (2000) 127 (5): 957–967.
Published: 1 March 2000
... requirement for two different Bmp ligand subclass genes for dorsoventral pattern formation of the zebrafish embryo. From the relative efficiencies observed in Bmp ligand rescue experiments, conserved chromosomal synteny, and isolation of the zebrafish bmp7 gene, we determined that the strongly dorsalized...
Journal Articles
Journal Articles
Journal: Development
Development (1999) 126 (5): 895–902.
Published: 1 March 1999
... the signalling molecule Bmp7 as the mediator of this inductive interaction. This molecule is expressed in a manner consistent with it playing such a role and, when added to ectoderm explants, it will promote the formation of epibranchial neuronal cells. Moreover, the Bmp7 antagonist follstatin will block...
Journal Articles
Journal: Development
Development (1999) 126 (2): 397–408.
Published: 15 January 1999
... by sonic hedgehog (SHH) secreted from the notochord whereas ventral midline cells of the rostral diencephalon (RDVM cells) appear to be induced by the dual actions of SHH and bone morphogenetic protein 7 (BMP7) from prechordal mesoderm. We have examined the cellular and molecular events that govern...