... pole transport. Thus, vegetal ablation at the two-cell stage could remove most of the Vrtn antagonists, and allows Vrtn to produce the dorsalising effect. Mechanistically, Vrtn binds a bmp2b regulatory sequence and acts as a repressor to inhibit its zygotic transcription. Analysis of maternal-zygotic...

... in laf m100 , Alk8 is prematurely terminated directly after the transmembrane domain. The zygotic effect of both mutations leads to dorsalization of intermediate strength. A much stronger dorsalization, similar to that of bmp2b / swirl and bmp7 / snailhouse mutants, however, is obtained by inhibiting...

...Vu H. Nguyen; Jamie Trout; Stephanie A. Connors; Peter Andermann; Eric Weinberg; Mary C. Mullins We have studied the role of Bmp signaling in patterning neural tissue through the use of mutants in the zebrafish that disrupt three different components of a Bmp signaling pathway: swirl/bmp2b...

... of the strongest dorsalized zebrafish mutant swirl/bmp2b , revealing equivalent genetic roles for these two Bmp ligands. Double mutant snailhouse/bmp7; swirl/bmp2b embryos do not exhibit additional or stronger dorsalized phenotypes, indicating that these Bmp ligands do not function redundantly in early embryonic...

... for the specification of ventral cell fates during early dorsoventral patterning. At higher temperature, the phenotype of snh ty68 mutant embryos is identical to that caused by the amorphic bmp2b mutation swirl swr ta72 and similar to that caused by the smad5 mutation somitabun sbn dtc24 . mRNA injection studies...