...Alexandra Schauer; Kornelija Pranjic-Ferscha; Robert Hauschild; Carl-Philipp Heisenberg ABSTRACT Embryogenesis results from the coordinated activities of different signaling pathways controlling cell fate specification and morphogenesis. In vertebrate gastrulation, both Nodal and BMP signaling play...

... and reduced skeletal growth in juvenile mice. Overall, we conclude that Wnt7b is a crucial factor secreted from hypertrophic chondrocytes to initiate endochondral ossification. These results suggest that Smad4-dependent BMP signaling regulates the Wnt7b–β-catenin axis during endochondral ossification...

... signaling of bone morphogenetic proteins (BMP) in these cells. Overexpression of inhibitory human SMAD6 ( huSMAD6 ) in limb MPCs abrogated BMP signaling, impaired their migration and proliferation, and accelerated myogenic lineage progression. Fewer primary myofibers developed, causing an aberrant...

...Leslie Dunipace; Susan Newcomb; Angelike Stathopoulos ABSTRACT A limited BMP signaling range in the stem cell niche of the ovary protects against germ cell tumors and promotes germ cell homeostasis. The canonical repressor of BMP signaling in both the Drosophila embryo and wing disc...

... pSer-19-mediated MLC2 contractility. The compressive stress acts through BMP signaling to increase cell proliferation and decrease cell contractility, and MEK-ERK is essential for both compressive stress and BMP mediation of compaction. We further showed that the effects of osmotic stress are conserved...

.... , Unger , C. and Andrews , P. W. ( 2017 ). Top-down inhibition of BMP signaling enables robust induction of hPSCs into neural crest in fully defined, xeno-free conditions . Stem Cell Rep.   9 , 1043 - 1052 . 10.1016/j.stemcr.2017.08.008 Heemskerk , I. , Burt , K. , Miller , M...

... erythropoiesis, encodes a C2H2 zinc-finger protein that inhibits BMP signaling. We therefore named this gene blood-inducing factor 1 and BMP inhibitory factor 1 ( bif1 ). We identified a bif1 ortholog in Sinocyclocheilus rhinocerous , another fish, and in the mouse genome. Both genes also inhibit BMP signaling...

...://www.biologists.com/user-licence-1-1/ Summary: Cellular, transcriptome and gene functional analyses revealed that tail regeneration of amphioxus is a vertebrate-like epimorphic process, in which the BMP signaling pathway plays key roles. Tail regeneration Amphioxus Transcriptome BMP signaling...

... was upregulated by KO of Dppa2 in ESCs ( Table S4 ; Nakamura et al., 2011 ; GSE31581), which is repressed by SETDB1 ( Fig. 4 A), suggesting that SETDB1 stimulates Wnt3a expression by repressing Dppa2 expression. Our present results suggest that OXT2 represses BMP signaling genes ( Fig. 6 B,E...

... regulates BMP signaling. From these results, we conclude that Fam46a is required for PPE formation via the positive regulation of BMP signaling. Our study provides a new mechanism of ectodermal patterning via cell-autonomous regulation of BMP signaling in the PPE. * Present address: National...

... negative genetic interactions identified in our study (red) in the context of known remodeling factors (black). Myc and brat rescue morphological defects in loss-of- shep B SEG and B AG neurons, respectively, whereas components of BMP signaling pathway affect remodeling of both bursicon neuron...

... under the action of the segmentation clock. The signals responsible for tailbud mesoderm progenitor pool maintenance during axial elongation are still elusive. Here, we show that Bmp signaling is sufficient to activate the entire mesoderm progenitor gene signature in primary cultures of caudal mesoderm...

... of skeletal muscle largely depends on the expansion and differentiation of resident stem cells, the so-called satellite cells. Here, we demonstrate that postnatal satellite cells express components of the bone morphogenetic protein (BMP) signaling machinery. Overexpression of noggin in postnatal mice...

... affecting EE tissue specification or maintenance. These macroevolutionary changes in function between Tribolium and Drosophila are accompanied by regulatory network changes, where BMP signaling and possibly the transcription factor Hindsight are downstream mediators. We propose that the ancestral role...

..., including the Bone morphogenetic protein (Bmp) pathway. However, the role of Bmp signaling in pouch morphogenesis is poorly understood. Using genetic and chemical inhibitor approaches, we show that pouch morphogenesis requires Bmp signaling from 10-18 h post-fertilization, immediately following gastrulation...

...-renewal and differentiation in a clonal organoid (tracheosphere) assay. This revealed that inhibitors of the canonical BMP signaling pathway promote proliferation but do not affect lineage choice, whereas exogenous Bmp4 inhibits proliferation and differentiation. We therefore followed changes in BMP...

... in cardiomyocyte numbers. Cell-tracing experiments, using photoconvertable fluorescent proteins and genetic labeling, demonstrate that Gpc4 ‘Knypek’ is required for specification of cardiac progenitor cells and their differentiation into cardiomyocytes. Mechanistically, we show that Bmp signaling is enhanced...

... the specificity of cell fate control by distinctive Mediator subunits. Gene profiling revealed that Med23 depletion attenuated BMP signaling in ESCs. Mechanistically, MED23 modulated Bmp4 expression by controlling the activity of ETS1, which is involved in Bmp4 promoter-enhancer communication. Interestingly...

...Mikolaj Sulkowski; Young-Jun Kim; Mihaela Serpe Effective communication between pre- and postsynaptic compartments is required for proper synapse development and function. At the Drosophila neuromuscular junction (NMJ), a retrograde BMP signal functions to promote synapse growth, stability...

...Chenxi Tian; Herong Shi; Shan Xiong; Fenghua Hu; Wen-Cheng Xiong; Jun Liu The deleted in colorectal cancer (DCC) homolog neogenin functions in both netrin- and repulsive guidance molecule (RGM)-mediated axon guidance and in bone morphogenetic protein (BMP) signaling. How neogenin functions...