.... BMP Cell specification Dorsal interneurons Dorsal root ganglia Melanocytes Neural crest Neural tube Notch Roof plate Single cell RNA sequencing Israel Science Foundation https://dx.doi.org/10.13039/501100003977 ISF #219/23 Zelman Cowen Academic Initiatives ZCAI...

... inhibited tooth formation. Thus, similar to known roles in hair regeneration, Wnt and BMP signals promote and inhibit regeneration, respectively. Regulation of total tooth number was separable from regulation of replacement rates. RNA sequencing of stickleback dental tissue showed that Bmp6 overexpression...

... in the oral epithelium. Building on previous knowledge, we explored the hair-inductive ability of the Wnt agonist R-spondin 1 and a Bmp receptor inhibitor in embryonic skin explants. Although R-spondin 1 instigated precocious placode-specific transcriptional responses, it was insufficient for hair follicle...

... Fibroblasts BMP References Anderson , D. E. , Markway , B. D. , Weekes , K. J. , McCarthy , H. E. and Johnstone , B. ( 2018 ). Physioxia promotes the articular chondrocyte-like phenotype in human chondroprogenitor-derived self-organized tissue . Tissue Eng. Part A 24...

...Molly R. Kulikauskas; Morgan Oatley; Tianji Yu; Ziqing Liu; Lauren Matsumura; Elise Kidder; Dana Ruter; Victoria L. Bautch ABSTRACT BMP signaling is crucial to blood vessel formation and function, but how pathway components regulate vascular development is not well-understood. Here, we find...

... that they also share gene expression profiles with vertebrate anterior neural tissue and cranial placodes, their study should shed light on the emergence of the unique vertebrate telencephalon. We show that BMP signaling regulates two phases of palp formation in Ciona intestinalis . During gastrulation...

... are a predominant cause of congenital thyroid diseases. The first molecularly recognizable step of thyroid development is the specification of thyroid precursors in anterior foregut endoderm. Recent studies have identified crucial roles of FGF and BMP signaling in thyroid specification, but the interplay between...

...Julie Gamart; Iros Barozzi; Frédéric Laurent; Robert Reinhardt; Laurène Ramos Martins; Thomas Oberholzer; Axel Visel; Rolf Zeller; Aimée Zuniga ABSTRACT SMAD4 regulates gene expression in response to BMP and TGFβ signal transduction, and is required for diverse morphogenetic processes, but its...

...Mari Ichinose; Nobumi Suzuki; Tongtong Wang; Hiroki Kobayashi; Laura Vrbanac; Jia Q. Ng; Josephine A. Wright; Tamsin R. M. Lannagan; Krystyna A. Gieniec; Martin Lewis; Ryota Ando; Atsushi Enomoto; Simon Koblar; Paul Thomas; Daniel L. Worthley; Susan L. Woods ABSTRACT Bone morphogenetic protein (BMP...

... degenerate and the Wolffian ducts differentiate into vas deferens, epididymis and seminal vesicle. The degeneration of the Müllerian ducts in males are ascribed to apoptotic effect of anti-Müllerian hormone (AMH), a BMP subfamily member that is secreted by Sertoli cells in the developing testis ( Klattig...

..., is identified as a master gene in hindbrain choroid plexus patterning and multiciliogenesis. Choroid plexus Patterning Development Hindbrain Wnt BMP Cilium Multiciliated cells Multiciliated epithelium Microvilli Zfp423 ZNF423 Joubert syndrome JS19 Hydrocephalus The choroid plexus...

...Alexis R. Lanza; Elaine C. Seaver ABSTRACT The TGF-β superfamily comprises two distinct branches: the Activin/Nodal and BMP pathways. During development, signaling by this superfamily regulates a variety of embryological processes, and it has a conserved role in patterning the dorsal-ventral body...

... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages...

..., we use the BMP signaling inhibitor LDN193189 on Ambystoma mexicanum to explore the role of BMPs in regeneration. We find that BMP signaling is required for proper expression of various patterning genes and that its inhibition causes major defects in the regenerated limbs. Fgf8 is downregulated when...

... ). In addition, the nascent DM controls the timing of neural crest delamination by modulating noggin mRNA and BMP activity in the NT ( Sela-Donenfeld and Kalcheim, 2000 ). Reciprocally, Bmp4 and/or Wnt1 from the NT pattern somite-derived myogenesis ( Abu-Elmagd et al., 2010 ; Marcelle et al., 1997...

... protein (BMP) signal transduction in postnatal mice, with BMP signaling being restricted to basal VSNs and at the marginal zones of the VNO: the site of neurogenesis. Using different Smad4 conditional knockout mouse models, we disrupted canonical TGFβ/BMP signaling in either maturing basal VSNs (bVSNs...

... between GSCs and daughter cells, and overproliferation of GSC progeny. Mechanistically, Wh interacts with Mei-p26 in different cellular contexts to induce cell type-specific effects. In GSCs, Wh and Mei-p26 promote BMP stemness signaling for proper GSC division and maintenance. In GSC progeny, Wh and Mei...

... School) entitled ‘Morphogenetic control of zebrafish cardiac looping by Bmp signaling’. Author contributions Conceptualization: V.A.L., M.H., J.M., S.A.-S.; Methodology: V.A.L., M.H., M.M., D.B., S.A.-S.; Software: V.A.L., M.H., M.M.; Validation: V.A.L., M.H., S.A.-S.; Formal analysis: V.A.L...

.... Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative in vivo imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that Bmp signaling and the actomyosin cytoskeleton promote constriction of the DP, which enables...

...: Interaction between endocardial cells and cardiomyocytes during the initial stages of in vitro cardiac differentiation promotes myocardial differentiation and maturation through the BMP signaling pathway. Bmp ESC Endocardium Multipotent progenitor Myocardium Mouse National Heart, Lung...