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Keywords: Bmp
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Journal Articles
Journal: Development
Development (2021) 148 (5): dev188490.
Published: 12 March 2021
... developmental functions of TGFβ family proteins. BMP Development Embryo Nodal TGFβ Transforming growth factor β (TGFβ) was first discovered in the late 1970s as a secreted polypeptide growth factor with the ability to transform mammalian fibroblasts ( Moses et al., 2016 ). Since then, a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev190173.
Published: 30 November 2020
... identified as a master gene in hindbrain choroid plexus patterning and multiciliogenesis. Choroid plexus Patterning Development Hindbrain Wnt BMP Cilium Multiciliated cells Multiciliated epithelium Microvilli Zfp423 ZNF423 Joubert syndrome JS19 Hydrocephalus The choroid plexus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev189373.
Published: 23 September 2020
...Alexis R. Lanza; Elaine C. Seaver ABSTRACT The TGF-β superfamily comprises two distinct branches: the Activin/Nodal and BMP pathways. During development, signaling by this superfamily regulates a variety of embryological processes, and it has a conserved role in patterning the dorsal-ventral body...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188839.
Published: 15 September 2020
... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev170829.
Published: 31 July 2020
..., we use the BMP signaling inhibitor LDN193189 on Ambystoma mexicanum to explore the role of BMPs in regeneration. We find that BMP signaling is required for proper expression of various patterning genes and that its inhibition causes major defects in the regenerated limbs. Fgf8 is downregulated when...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev183996.
Published: 26 May 2020
.... Summary: Loss- and gain-of-function, and floor plate deletions, reveal that Shh that transits through the sclerotome is presented to the neuroepithelium from its basal aspect to affect motoneuron development. BMP Dermomyotome Dorso-ventral patterning Hb9 Motoneurons Myotome Neural tube Nkx...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184036.
Published: 27 April 2020
... protein (BMP) signal transduction in postnatal mice, with BMP signaling being restricted to basal VSNs and at the marginal zones of the VNO: the site of neurogenesis. Using different Smad4 conditional knockout mouse models, we disrupted canonical TGFβ/BMP signaling in either maturing basal VSNs (bVSNs) or...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev182063.
Published: 15 January 2020
... between GSCs and daughter cells, and overproliferation of GSC progeny. Mechanistically, Wh interacts with Mei-p26 in different cellular contexts to induce cell type-specific effects. In GSCs, Wh and Mei-p26 promote BMP stemness signaling for proper GSC division and maintenance. In GSC progeny, Wh and Mei...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180091.
Published: 14 November 2019
... Article: The asymmetric activity of Bmp signaling within the superior atrioventricular canal is essential for normal looping morphogenesis of the zebrafish heart. BMP Wnt Cardiac looping Hemodynamics Zebrafish The term ‘cardiac looping’ defines a morphogenetic process during vertebrate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174961.
Published: 04 July 2019
.... Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative in vivo imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that Bmp signaling and the actomyosin cytoskeleton promote constriction of the DP, which enables...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev172619.
Published: 08 May 2019
... Article: Interaction between endocardial cells and cardiomyocytes during the initial stages of in vitro cardiac differentiation promotes myocardial differentiation and maturation through the BMP signaling pathway. We thank Christopher B. Brown PhD for his support on experimental design and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev167452.
Published: 28 February 2019
... applied to achieve anatomical and ultimately functional variation during sesamoid bone development. Sesamoid bone Joint Sox9 Scleraxis Tgfβ BMP Mouse Sesamoid bones constitute a special group of bones that are integral to the skeletons of many vertebrate species ( Abdala et al., 2017...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev166876.
Published: 28 November 2018
... mutants that have lost the energy sensor AMP-activated protein kinase (AMPK) or the insulin/IGF-1 signaling (IIS) negative regulator DAF-18/PTEN. We report that DBL-1/BMP works upstream of IIS to promote agonistic insulin-like peptides during L1 arrest. However, the abnormal Q cell divisions that occur...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163519.
Published: 10 August 2018
... similarly descend from scleraxis- and Sox9-expressing progenitors; however, Hyp entheses exhibit an expansion of Sox9-expressing cells, and enhanced BMP and IHH signaling. These results support a role for enhanced BMP and IHH signaling in the development of enthesopathy in XLH. * Author for...
Journal Articles
Journal: Development
Development (2018) 145 (14): dev159368.
Published: 17 July 2018
... in the control of initial DV polarity by promoting the development of the ventral center and by destabilizing transcriptionally active β-catenin. Notch β-catenin Dorsoventral development BMP Wnt8a Ventx Xenopus Zebrafish During the past two decades, many studies, mostly...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev163014.
Published: 11 May 2018
...Mei-I Chung; Melissa Bujnis; Christina E. Barkauskas; Yoshihiko Kobayashi; Brigid L. M. Hogan ABSTRACT The bone morphogenetic protein (BMP) signaling pathway, including antagonists, functions in lung development and regeneration of tracheal epithelium from basal stem cells. Here, we explore its...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4476–4480.
Published: 15 December 2017
.... BMP Cancer TGFβ Signal transduction There has been substantial progress in the application of checkpoint inhibitors, such as antibodies against CTLA4, PD-1 (PDCD1) or PD-L1 (CD274), in cancer immunotherapy ( Topalian et al., 2015 ), and TGFβ inhibitors hold similar promise. Rosemary Akhurst...
Journal Articles
Journal: Development
Development (2017) 144 (15): 2771–2783.
Published: 01 August 2017
... modulate the temporal dynamics of Dpp presentation in developmental BMP signaling, impacting the downstream transcriptional response and tissue morphogenesis. Fly wing morphogenesis Dpp BMP Bioelectric signaling KCNJ2 Drosophila melanogaster Dominant-negative mutations in the gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2560–2569.
Published: 15 July 2017
... as a model with which to investigate how the BMP signaling pathway regulates transcriptional complexes to direct the fate determination of multipotent mesenchymal stem cells (MSCs). We first identified the MSC population supporting mouse molar root growth as Gli1 + cells. Using a Gli1-driven Cre...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1283–1295.
Published: 01 April 2017
... the genome is poorly understood. Here we identified the transcriptomes of Xenopus foregut and hindgut progenitors, which are conserved with mammals. Using RNA-seq and ChIP-seq we show that BMP/Smad1 regulates dorsal-ventral gene expression in both the endoderm and mesoderm, whereas Wnt/β-catenin acts...
Includes: Supplementary data