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Keywords: Bmp
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Journal Articles
Journal: Development
Development (2021) 148 (23): dev200182.
Published: 3 December 2021
...Julie Gamart; Iros Barozzi; Frédéric Laurent; Robert Reinhardt; Laurène Ramos Martins; Thomas Oberholzer; Axel Visel; Rolf Zeller; Aimée Zuniga ABSTRACT SMAD4 regulates gene expression in response to BMP and TGFβ signal transduction, and is required for diverse morphogenetic processes, but its...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (14): dev195883.
Published: 12 July 2021
...Mari Ichinose; Nobumi Suzuki; Tongtong Wang; Hiroki Kobayashi; Laura Vrbanac; Jia Q. Ng; Josephine A. Wright; Tamsin R. M. Lannagan; Krystyna A. Gieniec; Martin Lewis; Ryota Ando; Atsushi Enomoto; Simon Koblar; Paul Thomas; Daniel L. Worthley; Susan L. Woods ABSTRACT Bone morphogenetic protein (BMP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev188490.
Published: 12 March 2021
... and developmental functions of TGFβ family proteins. BMP Development Embryo Nodal TGFβ Transforming growth factor β (TGFβ) was first discovered in the late 1970s as a secreted polypeptide growth factor with the ability to transform mammalian fibroblasts ( Moses et al., 2016 ). Since...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (22): dev190173.
Published: 30 November 2020
..., is identified as a master gene in hindbrain choroid plexus patterning and multiciliogenesis. Choroid plexus Patterning Development Hindbrain Wnt BMP Cilium Multiciliated cells Multiciliated epithelium Microvilli Zfp423 ZNF423 Joubert syndrome JS19 Hydrocephalus The choroid plexus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev189373.
Published: 23 September 2020
...Alexis R. Lanza; Elaine C. Seaver ABSTRACT The TGF-β superfamily comprises two distinct branches: the Activin/Nodal and BMP pathways. During development, signaling by this superfamily regulates a variety of embryological processes, and it has a conserved role in patterning the dorsal-ventral body...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188839.
Published: 15 September 2020
... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev170829.
Published: 31 July 2020
..., we use the BMP signaling inhibitor LDN193189 on Ambystoma mexicanum to explore the role of BMPs in regeneration. We find that BMP signaling is required for proper expression of various patterning genes and that its inhibition causes major defects in the regenerated limbs. Fgf8 is downregulated when...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev183996.
Published: 26 May 2020
... Marcelle , C. , Stark , M. R. and Bronner-Fraser , M. ( 1997 ). Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite . Development   124 , 3955 - 3963 . Matise , M. P. , Epstein , D. J. , Park , H. L. , Platt , K. A. and Joyner...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (8): dev184036.
Published: 27 April 2020
... protein (BMP) signal transduction in postnatal mice, with BMP signaling being restricted to basal VSNs and at the marginal zones of the VNO: the site of neurogenesis. Using different Smad4 conditional knockout mouse models, we disrupted canonical TGFβ/BMP signaling in either maturing basal VSNs (bVSNs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev182063.
Published: 15 January 2020
... between GSCs and daughter cells, and overproliferation of GSC progeny. Mechanistically, Wh interacts with Mei-p26 in different cellular contexts to induce cell type-specific effects. In GSCs, Wh and Mei-p26 promote BMP stemness signaling for proper GSC division and maintenance. In GSC progeny, Wh and Mei...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180091.
Published: 14 November 2019
...: The asymmetric activity of Bmp signaling within the superior atrioventricular canal is essential for normal looping morphogenesis of the zebrafish heart. BMP Wnt Cardiac looping Hemodynamics Zebrafish For pharmacological treatments, embryos were incubated in egg-water supplemented with 20 μM...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174961.
Published: 4 July 2019
.... Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative in vivo imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that Bmp signaling and the actomyosin cytoskeleton promote constriction of the DP, which enables...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev172619.
Published: 8 May 2019
... , J. and Keller , G. ( 2011 ). Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines . Cell Stem Cell   8 , 228 - 240 . 10.1016/j.stem.2010.12.008 Kubalak , S. W. , Miller-Hance , W. C...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev167452.
Published: 28 February 2019
.... Sesamoid bone Joint Sox9 Scleraxis Tgfβ BMP Mouse Sesamoid bones constitute a special group of bones that are integral to the skeletons of many vertebrate species ( Abdala et al., 2017 ; Bizarro, 1921 ; Corina Vera et al., 2015 ; Jerez et al., 2009 ; Maisano, 2002 ; Ponssa et al., 2010...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev166876.
Published: 28 November 2018
... in mutants that have lost the energy sensor AMP-activated protein kinase (AMPK) or the insulin/IGF-1 signaling (IIS) negative regulator DAF-18/PTEN. We report that DBL-1/BMP works upstream of IIS to promote agonistic insulin-like peptides during L1 arrest. However, the abnormal Q cell divisions that occur...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163519.
Published: 10 August 2018
... descend from scleraxis- and Sox9-expressing progenitors; however, Hyp entheses exhibit an expansion of Sox9-expressing cells, and enhanced BMP and IHH signaling. These results support a role for enhanced BMP and IHH signaling in the development of enthesopathy in XLH. As the cells in the enthesis...
Journal Articles
Journal: Development
Development (2018) 145 (14): dev159368.
Published: 17 July 2018
... early embryogenesis, ventrally enriched Notch1 participates in the control of initial DV polarity by promoting the development of the ventral center and by destabilizing transcriptionally active β-catenin. Notch β-catenin Dorsoventral development BMP Wnt8a Ventx Xenopus Zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev163014.
Published: 11 May 2018
...Mei-I Chung; Melissa Bujnis; Christina E. Barkauskas; Yoshihiko Kobayashi; Brigid L. M. Hogan ABSTRACT The bone morphogenetic protein (BMP) signaling pathway, including antagonists, functions in lung development and regeneration of tracheal epithelium from basal stem cells. Here, we explore its...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4476–4480.
Published: 15 December 2017
.... , Xu , M. , Feldman , G. J. , Fenstermacher , D. A. , Cho , T.-J. , Choi , I. H. , Connor , J. M. , Delai , P. , Glaser , D. L. , LeMerrer , M. , et al. ( 2006 ). A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia...
Journal Articles
Journal: Development
Development (2017) 144 (15): 2771–2783.
Published: 1 August 2017
.... ( 2013 ). Retrograde BMP signaling at the synapse: a permissive signal for synapse maturation and activity-dependent plasticity . J. Neurosci.   33 , 17937 - 17950 . 10.1523/JNEUROSCI.6075-11.2013 Bichet , D. , Haass , F. A. and Jan , L. Y. ( 2003 ). Merging functional studies...
Includes: Supplementary data