... to the periphery of the myofiber. Blood vessels (BVs) are important contributors to the correct development of skeletal muscle, and myonuclei are found next to BVs in adult muscle. Here, we show that most myonuclear migration to the periphery occurs between embryonic day 17.5 and postnatal day 1 in mouse...

...Kishor K. Sivaraj; Ralf H. Adams In addition to their conventional role as a conduit system for gases, nutrients, waste products or cells, blood vessels in the skeletal system play active roles in controlling multiple aspects of bone formation and provide niches for hematopoietic stem cells...

...Alexandra M. Ochsenbein; Sinem Karaman; Steven T. Proulx; Michaela Berchtold; Giorgia Jurisic; Esther T. Stoeckli; Michael Detmar Vascular endothelial growth factor (VEGF)-A is a well-known major chemoattractant driver of angiogenesis – the formation of new blood vessels from pre-existing ones...

... clear that the ECM plays an important role in the patterning and development of the vascular system by binding to, and regulating the availability and activity of, numerous growth factors and morphogens. Aneurysms Blood vessels Cardiovascular development Integrin Neural crest Vascular...

... forms a web-like blood vessel network that penetrates the supportive epidermis of BTs. Upon analyzing the effects of sex steroids and their inhibitors, we show that androgens induce and estrogens inhibit BT cluster formation in intact and regenerating pectoral fins. Androgen-induced BT formation...

... that biomechanics is key in controlling early flow propagation and argue that intravascular elasticity has a role in determining embryonic vascular function. Biomechanics Blood vessels Hemodynamics Low Reynolds number Zebrafish We performed high temporal resolution imaging in zebrafish...

... their niche. Endogenous progenitor cell recruitment towards the lesion was significantly reduced by inhibiting post-lesional angiogenesis in the SVZ using anti-VEGF blocking antibody injections, suggesting a facilitating role of blood vessels for progenitor cell migration towards the lesion. We identified...

...Judith Magenheim; Ohad Ilovich; Alon Lazarus; Agnes Klochendler; Oren Ziv; Roni Werman; Ayat Hija; Ondine Cleaver; Eyal Mishani; Eli Keshet; Yuval Dor How organ size and form are controlled during development is a major question in biology. Blood vessels have been shown to be essential for early...

...Heloise West; William D. Richardson; Marcus Fruttiger Development of the retinal vasculature is controlled by a hierarchy of interactions among retinal neurons, astrocytes and blood vessels. Retinal neurons release platelet-derived growth factor (PDGFA) to stimulate proliferation of astrocytes...

... of developing bones between wild-type and VEGF 120/120 mice. VEGF 120/120 mice have not only a delayed recruitment of blood vessels into the perichondrium but also show delayed invasion of vessels into the primary ossification center, demonstrating a significant role of VEGF at both an early and late stage...

.... Genome 10 , 913 -915. Reese, D. E., Zavaljevski, M., Streiff, N. L. and Bader, D. ( 1999 ). bves: a novel gene expressed during coronary blood vessel development. Dev. Biol . 209 , 159 -171. Schmidt-Rose, T. and Jentsch, T. J. ( 1997 ). Transmembrane topology of a CLC chloride channel...

... and optic nerve. * Author for correspondence 12 03 1993 © 1993 by Company of Biologists 1993 PDGF PDGF receptors retina optic nerve neurons glial cells blood vessels in situ hybridization immunohistochemistry rat mouse Many polypeptide growth factors are expressed...

... dermis blood vessels cutaneous nerves The innervation of a vertebrate limb consists of a set of mixed nerve trunks from which two main sets of branches diverge: those that go to muscles and those that go to the skin. We have previously examined the role of muscles in controlling routes of nerve...

... embryonic mesenchy- mal and epithelial tissues and participating in new blood vessel formation in distant sites. The interactions leading to proper spatial pattern- ing of craniofacial skeletal, muscular, vascular and peripheral neural tissues has been studied by perform- ing heterotopic transplants of each...