1-20 of 21
Keywords: Blastema
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2022) 149 (8): dev199916.
Published: 9 November 2021
.... RNAi of Toll2-2 led to a decrease in the ratio of S- and M-phase cells, reduced expression of JAK/STAT signalling genes, and reduced accumulation of plasmatocytes in the blastema. Depletion of plasmatocytes in crickets using clodronate also produced regeneration defects, as well as fewer proliferating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (22): 4047–4060.
Published: 15 November 2017
... and regeneration of different tissues and organs and in different organisms, ranging from planarians to humans. FGF Regeneration Repair Blastema Injury Wound The ability to regenerate injured tissues and organs, and even amputated body parts, is a long-standing aspiration for humankind...
Journal Articles
Journal: Development
Development (2017) 144 (21): 3907–3916.
Published: 1 November 2017
... process. Using cell-depletion strategies, we show that regeneration is completely inhibited; bone histolysis does not occur, wound re-epithelialization is inhibited and the blastema does not form. Although rescue of epidermal wound closure in the absence of macrophages promotes blastema accumulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (5): 784–794.
Published: 1 March 2017
...Nicolle A. Bonar; Christian P. Petersen Animals capable of adult regeneration require specific signaling to control injury-induced cell proliferation, specification and patterning, but comparatively little is known about how the regeneration blastema assembles differentiating cells into well...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3491–3505.
Published: 1 October 2016
...Adam B. Cook; Ashley W. Seifert Epimorphic regeneration proceeds with or without formation of a blastema, as observed for the limb and skin, respectively. Inhibition of epimorphic regeneration provides a means to interrogate the cellular and molecular mechanisms that regulate it. In this study, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2920–2929.
Published: 15 August 2016
... elucidated. Here, we performed comprehensive expression analyses and identified fgf20a and fgf3 / 10a as major Fgf ligands in the wound epidermis and blastema, respectively. To reveal the target cells and processes of Fgf signalling, we performed a transplantation experiment of mesenchymal cells that express...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2946–2957.
Published: 15 August 2016
...Thomas P. Lozito; Rocky S. Tuan Lizards are amniotes with the remarkable ability to regenerate amputated tails. The early regenerated lizard tail forms a blastema, and the regenerated skeleton consists of a cartilage tube (CT) surrounding the regenerated spinal cord. The proximal, but not distal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3754–3764.
Published: 15 September 2013
... regeneration blastema, yet modified the lengths and widths of regenerating bones. Hand2 influenced the character of regenerated rays in part by elevation of the vitamin D-inactivating enzyme encoded by cyp24a1 , contributing to region-specific regulation of bone metabolism. Systemic administration of vitamin D...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (7): 1412–1423.
Published: 1 April 2013
...Bartholomäus Grotek; Daniel Wehner; Gilbert Weidinger Zebrafish can completely regenerate amputated fins via formation of a blastema, a proliferative mass of undifferentiated precursor cells. During regenerative growth, blastema proliferation must be tightly coordinated with cellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (7): 1402–1411.
Published: 1 April 2013
...-like cells, called blastema. This tissue provides all the cell types that form the fin, so that after damage or amputation the fin pattern and structure are fully restored. How blastema cells remain in this progenitor-like state is poorly understood. Here, we show that the Notch pathway plays...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (5): 951–957.
Published: 1 March 2013
...Peter W. Reddien Planarians are flatworms capable of regenerating all body parts. Planarian regeneration requires neoblasts, a population of dividing cells that has been studied for over a century. Neoblast progeny generate new cells of blastemas, which are the regenerative outgrowths at wounds...
Journal Articles
Journal: Development
Development (2013) 140 (5): 959–964.
Published: 1 March 2013
...Tetsuya Bando; Yoshiyasu Ishimaru; Takuro Kida; Yoshimasa Hamada; Yuji Matsuoka; Taro Nakamura; Hideyo Ohuchi; Sumihare Noji; Taro Mito In the cricket Gryllus bimaculatus , missing distal parts of the amputated leg are regenerated from the blastema, a population of dedifferentiated proliferating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (12): 2417–2427.
Published: 15 June 2011
... mitotic cells in adults and are responsible for blastema formation after amputation. The molecular mechanism underlying neoblast differentiation associated with blastema formation remains unknown. Here, using the planarian Dugesia japonica we found that DjmkpA , a planarian mitogen-activated protein...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (6): 871–879.
Published: 15 March 2010
... of the blastema. It has been known for decades that contact between the wound epithelium and the underlying blastema is essential for successful regeneration. However, the underlying mechanisms are poorly understood. Here, we show that upon amputation the blastema induces expression of the ligand Igf2b, which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (4): 551–559.
Published: 15 February 2010
... the formation of a mammalian digit blastema. Unlike the endogenous regeneration response that involves redifferentiation by direct ossification (evolved regeneration), the BMP-induced response involves endochondral ossification (redevelopment). Our evidence suggests that BMP treatment triggers a reprogramming...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (18): 3063–3070.
Published: 15 September 2008
...Airon A. Wills; Ambrose R. Kidd, III; Alexandra Lepilina; Kenneth D. Poss Adult teleost fish and urodele amphibians possess a spectacular ability to regenerate amputated appendages, based on formation and maintenance of progenitor tissue called a blastema. Although injury-induced, or facultative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (23): 5173–5183.
Published: 1 December 2005
... and msxb-expressing distal blastema directs zebrafish fin regeneration. Development 129 , 2607 -2617. Nechiporuk, A., Poss, K. D., Johnson, S. L. and Keating, M. T. ( 2003 ). Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (14): 3243–3253.
Published: 15 July 2005
... the spinal cord but is also transmitted to the surrounding blastema. Cyclopamine treatment revealed that hedgehog signaling is not only required for DV patterning of the regenerating spinal cord but also had profound effects on the regeneration of surrounding, mesodermal tissues. Proliferation of tail...
Journal Articles
Journal: Development
Development (2002) 129 (22): 5141–5149.
Published: 15 November 2002
... expression was specifically induced in the proximal regeneration blastema, a group of cells that normally proliferate intensely during outgrowth. The nightcap mutation caused severe defects in these cells. However, msxb -expressing blastemal cells immediately distal to this proliferative region did...
Journal Articles
Journal: Development
Development (2002) 129 (11): 2607–2617.
Published: 1 June 2002
...Alex Nechiporuk; Mark T. Keating Previous studies of zebrafish fin regeneration led to the notion that the regeneration blastema is a homogeneous population of proliferating cells. Here, we show that the blastema consists of two components with markedly distinct proliferation properties. During...