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Keywords: Bile Duct
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Journal Articles
Journal: Development
Development (2013) 140 (3): 639–648.
Published: 1 February 2013
..., of unknown genetic causes, that results in congenital deformation of the gallbladder and biliary duct system. Here, we show that during mouse organogenesis, insufficient SOX17 expression in the gallbladder and bile duct epithelia results in congenital biliary atresia and subsequent acute ‘embryonic hepatitis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (22): 5753–5766.
Published: 15 November 2004
... with an AGS phenocopy. These data confirm an evolutionarily conserved role for Notch signaling in vertebrate liver development, and support the zebrafish as a model system for diseases of the human biliary system. © 2004. 2004 Zebrafish Notch Jagged Alagille Syndrome Bile Duct Biliary Development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (8): 1829–1838.
Published: 15 April 2002
... embryonic death. In the present study, we have specifically inactivated this gene in hepatocytes and bile duct cells using the Cre/loxP system. Mutant animals exhibited severe jaundice caused by abnormalities of the gallbladder and intrahepatic bile ducts (IHBD). The paucity of small IHBD was linked...