... Pals1 mutants show defects in cerebellar organogenesis, with disrupted laminar organisation and impaired proliferation of cerebellar progenitors. Cerebellar development Pals1 Mpp5 Polarity complex proteins Germinal zones Mouse Bergmann glia A mature cerebellum includes Purkinje...

...Anupama Sathyamurthy; Dong-Min Yin; Arnab Barik; Chengyong Shen; Jonathan C. Bean; Dwight Figueiredo; Jin-Xiong She; Wen-Cheng Xiong; Lin Mei Cortical lamination is crucial for the assembly of cerebellar circuitry. In this process, granule neurons (GNs) migrate along Bergmann glia (BG), which...

... as a mechanism for abnormal laminar formation, the role of radial glia, which provide the environmental cues, in modulating neuronal migration is less clear. We provide evidence that loss of PTEN in Bergmann glia leads to premature differentiation of this crucial cell population and subsequently to extensive...

... partner systems. *Author for correspondence (e-mail: [email protected] ) 19 11 2001 © 2002. 2002 Mouse Cerebellum Granule Cell Purkinje Cell Bergmann Glia Behavior The creation of the laminated structure of the cerebellar and cerebral cortices is one of the most...

... for the proliferation of granule neuron precursors and it induces the differentiation of Bergmann glia. Blocking SHH function in vivo results in deficient granule neuron and Bergmann glia differentiation as well as in abnormal Purkinje neuron development. Thus, our findings provide a molecular model for the growth...

... enzyme reaction. (A) In P8 cerebellum, 9TM-1.6 is expressed in a layer of small cells in the Purkinje cells layer, which resembles Bergmann glia, and at a lower level in some spiny cells in the white matter. (B) Strong staining of β-galactosidase is can be observed in E14 lateral ventricle. (C) This 1.6...