... germ line tumors arise outside the gonads, and these are thought to arise from PGCs that fail to die in ectopic locations. We show that the pro-apoptotic gene Bax,previously shown to be required for germ cell death during later stages of their differentiation in the gonads, is also expressed during...

... enhancer that regulates TrkA expression in embryonic sensory neurons. We employ Bax -knockout mice, in which sensory neurons no longer require neurotrophins for survival, to uncouple TrkA-dependent cell death from downregulation of TrkA expression. In addition, when mutagenized, the novel Brn3a-binding...

...Gayle Middleton; Alun M. Davies Reports that apoptosis within populations of neurotrophin-dependent neurones is virtually eliminated in BAX-deficient mice and that BAX-deficient neurones survive indefinitely in culture without neurotrophins have led to the view that BAX is required for the death...

... in the cauda epididymis of adult Bcl6-deficient ( Bcl6 −/− ) mice is lower than that of Bcl6 +/+ mice. We have found numerous apoptotic spermatocytes at the metaphase I stage with induction of Bax protein in adult Bcl6 −/− testes. Developmentally, the incidence of germ cell apoptosis of Bcl6 −/− mice...

... marrow might be the result of a fast turnover of late red blood cell precursors and accelerated erythropoiesis in response to tissue hypoxia. The increase in cell death of late erythroid cells is independent from the proapoptotic factor Bax, as demonstrated in conditional double mutant mice for Bcl-x...

...Konstantinos Vekrellis; Mary Jane McCarthy; Andrea Watson; Jonathan Whitfield; Lee L. Rubin; Jonathan Ham ABSTRACT The Bcl-2 and Bcl-x proteins suppress programmed cell death, whereas Bax promotes apoptosis. We investigated the pattern of expression of Bcl-2, Bax and Bcl-x during neuronal...

... is not primarily involved in formation of the duct. Immunohistochemical examination of the expression of the apoptotic checkpoint proteins, Bcl-x, Bax and Bcl-2, demonstrated that they are expressed in the terminal endbud. Bcl-x and Bcl-2 expression is highest in the body cells and lowest in the non-apoptotic cap...

...Gayle Middleton; Gabriel Nunez; Alun M. Davies ABSTRACT Bcl-2, Bcl-x and Bax are members of a family of cytoplasmic proteins that influence cell survival. Whereas increased expression of Bcl-2 or Bcl-x promotes cell survival following withdrawal of survival factors, increased expression of Bax...