...Israt Jahan; Ning Pan; Jennifer Kersigo; Bernd Fritzsch Atoh1 , a basic helix-loop-helix (bHLH) transcription factor (TF), is essential for the differentiation of hair cells (HCs), mechanotransducers that convert sound into auditory signals in the mammalian organ of Corti (OC). Previous work...

..., planarians provide a powerful model to identify genes required for adult neurogenesis in vivo . We analyzed the basic helix-loop-helix (bHLH) family of transcription factors, many of which are crucial for nervous system development and have been implicated in human diseases. However, their potential roles...

... and one class of glial cells, all derived from a population of multipotent progenitors. There is little information on the molecular mechanisms governing the specification of cell type identity from multipotent progenitors in the developing retina. We report that Ptf1a, a basic-helix-loop-helix (bHLH...

... Retina patterning Basic helix-loop-helix Transcription Chick embryo The early development of the vertebrate central nervous system crucially depends on the timely generation of specific classes of neurons at distinct positions and in appropriate numbers. A large set of different regulatory...

...Dorota Skowronska-Krawczyk; Marc Ballivet; Brian D. Dynlacht; Jean-Marc Matter Basic helix-loop-helix (bHLH) transcription factors such as atonal homolog 5 (ATH5) and neurogenin 2 (NGN2) determine crucial events in retinogenesis. Using chromatin immunoprecipitation, we demonstrate...

...David G. McFadden; John McAnally; James A. Richardson; Jeroen Charité; Eric N. Olson Basic helix-loop-helix (bHLH) transcription factors control developmental decisions in a wide range of embryonic cell types. The HLH motif mediates homo- and heterodimerization, which juxtaposes the basic regions...

... of the homeobox proteins Pax6, Dbx2 and Msx1 generates precursor populations with distinct developmental potentials. Within the resulting populations, thresholds of BMP act to set expression domain boundaries of developmental regulators of the homeobox and basic helix-loop-helix (bHLH) families, ultimately...

...Doris Brown; Dan Wagner; Xiang-qing Li; James A. Richardson; Eric N. Olson ABSTRACT Scleraxis is a basic helix-loop-helix (bHLH) transcription factor shown previously to be expressed in developing chondrogenic cell lineages during embryogenesis. To investigate its function in embryonic development...

... achaete-scute basic helix-loop-helix neural induction The identification of genes that determine cell type and pattern within the nervous system is a fundamental problem of developmental neurobiology. In Drosophila , the achaetescute complex (AS-C) of four homologous genes (achaete, scute...

...Jane E. Johnson; Kathryn Zimmerman; Tetsuichiro Saito; David J. Anderson ABSTRACT MASH1 and MASH2, mammalian homologues of the Drosophila neural determination genes achaete-scute , are members of the basic helix-loop-helix (bHLH) family of transcription factors. We show here that murine P19...