...Apostolia Fragkouli; Nicole Verhey van Wijk; Rita Lopes; Nicoletta Kessaris; Vassilis Pachnis Coordination of voluntary motor activity depends on the generation of the appropriate neuronal subtypes in the basal ganglia and their integration into functional neuronal circuits. The largest nucleus...

... of Shh and Gli3 to generate ventral telencephalic cell types. Basal ganglia Ganglionic eminence FGF SHH GLI3 Telencephalon Patterning Mouse The vertebrate brain comprises a multitude of neural cell types organized into distinct functional areas. How are these areas generated during...

.... We show that the projections that do form between thalamic nuclei and neocortical domains have a shifted topography, in the absence of regionalization defects in the thalamus or neocortex. This shift is first detected inside the basal ganglia, a structure on the path of thalamic axons, and which...

... in the subventricular zone of the medial ganglionic eminence. Discrete neuronal populations of the basal ganglia and cerebral cortex are subsequently missing. An analysis of candidate effectors of Mash1 function revealed that the Notch ligands Dll1 and Dll3 , and the target of Notch signaling Hes5 , fail...