... Summary: A review of our current understanding of urothelial progenitor populations in the contexts of bladder organogenesis, regeneration and tumorigenesis. Basal cells Progenitors Retinoids Urothelial development Urothelium The bladder mediates crucial functions required...

... composed of multiciliated, goblet, club and basal cells, ensures proper mucociliary function and can regenerate in response to assaults. In chronic airway diseases, defective repair leads to tissue remodeling. Delineating key drivers of differentiation dynamics can help understand how normal...

... AKT or mTOR. Mammary gland development Lgr5 Mammary stem cells Basal cells Luminal cells mTOR signaling CBLB Casitas B-lineage lymphoma Mouse Postnatal organ development and maintenance require organ-resident stem cells. While mechanisms of hematopoietic stem cell (HSC...

...Tomomi Tadokoro; Xia Gao; Charles C. Hong; Danielle Hotten; Brigid L. M. Hogan The pseudostratified epithelium of the lung contains ciliated and secretory luminal cells and basal stem/progenitor cells. To identify signals controlling basal cell behavior we screened factors that alter their self...

...-dimensional imaging for keratin 5 further showed the unexpected presence of a layer of basal cells from the proximal airways to the distal bronchioles in E16.5 embryos. ChIP-seq analysis indicated the presence of Ezh2-mediated repressive marks on the genomic loci of some but not all basal genes, suggesting...

...Munemasa Mori; John E. Mahoney; Maria R. Stupnikov; Jesus R. Paez-Cortez; Aleksander D. Szymaniak; Xaralabos Varelas; Dan B. Herrick; James Schwob; Hong Zhang; Wellington V. Cardoso Basal cells are multipotent airway progenitors that generate distinct epithelial cell phenotypes crucial...

... displaced from the distal source of Fgf10 and differentiate into bronchial epithelial cells. Interestingly, our data presented here show that once epithelial cells are committed to the Sox2-positive airway epithelial cell fate, Fgf10 prevents ciliated cell differentiation and promotes basal cell...