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Development (2010) 137 (17): 2927–2937.
Published: 01 September 2010
... Xbap Bapx1 Nkx3.2 Craniofacial morphogenesis Jaw joint Neural crest cells Xenopus Serotonin Craniofacial morphogenesis is a complex developmental process requiring multiple and coordinated embryological events. The visceral skeleton of all jawed vertebrate embryos...
Includes: Supplementary data
Sylvain Provot, Hervé Kempf, L. Charles Murtaugh, Ung-il Chung, Dae-Won Kim, Jay Chyung, Henry M. Kronenberg, Andrew B. Lassar
Development (2006) 133 (4): 651–662.
Published: 15 February 2006
..., expression of Nkx3.2/Bapx1 in the growth plate is restricted to the proliferative zone and is downregulated as chondrocyte maturation begins. Nkx3.2/Bapx1 expression is lost in the growth plates of mice engineered to lack PTHrP signaling and, conversely, is maintained by ectopic expression of PTHrP...
Jacob Hecksher-Sørensen, Robert P. Watson, Laura A. Lettice, Palle Serup, Lorraine Eley, Carlo De Angelis, Ulf Ahlgren, Robert E. Hill
Development (2004) 131 (19): 4665–4675.
Published: 01 October 2004
... grow laterally but contain no endodermal component, showing that leftward growth is autonomous and independent of endoderm. In the Bapx1 –/– mutants, the SMP is defective. Normally, the SMP is a source for both Fgf9 and Fgf10; however, in the Bapx1 mutant, Fgf10 expression is downregulated...
Development (2004) 131 (10): 2443–2461.
Published: 15 May 2004
..., mirroring the first arch pattern. bapx1 , which is normally expressed in first arch postmigratory CNC prefiguring the jaw joint, is ectopically expressed in second arch CNC of moz mutants and hox2-MO injected animals. Reduction of bapx1 function in wild types causes loss of the jaw joint. Reduction of bapx1...
Development (2004) 131 (6): 1235–1245.
Published: 15 March 2004
... the ossicles to the skull. Except for the stapes, these skeletal elements are unique to mammals and are derived from the first and second branchial arches. We show that, in combination with goosecoid ( Gsc ), the Bapx1 gene defines the structural components of the murine middle ear. During embryogenesis, Bapx1...
Includes: Multimedia, Supplementary data
Development (2003) 130 (7): 1353–1365.
Published: 01 April 2003
... and joints in the anterior pharyngeal arches of young larvae. Here we present genetic analyses in the zebrafish of two edn1 downstream targets, the bHLH transcription factor Hand2 and the homeobox transcription factor Bapx1, that mediate dorsoventral (DV) patterning in the anterior pharyngeal arches. First...
Development (2003) 130 (3): 473–482.
Published: 01 February 2003
... and their target genes remain to be elucidated. We show, by analyzing Pax1;Pax9 double mutant mice, that expression of Bapx1 in the sclerotome requires the presence of Pax1 and Pax9, in a gene dose-dependent manner. By using a retroviral system to overexpress Pax1 in chick presomitic mesoderm explants, we show...