... and daughter cells. GSC Stem-cyst Abscission Mitosis Meiosis BMP Bam WDR4 Academia Sinica 10.13039/501100001869 Stem cell self-renewal and differentiation must be balanced for proper tissue homeostasis ( Nakada et al., 2011 ; Simons and Clevers, 2011 ; Spradling et al., 2011...

...Tsuyoshi Tokusumi; Yumiko Tokusumi; Dawn W. Hopkins; Robert A. Schulz Bag of Marbles (Bam) is known to function as a positive regulator of hematopoietic progenitor maintenance in the lymph gland blood cell-forming organ during Drosophila hematopoiesis. Here, we demonstrate a key function for Bam...

...Tsuyoshi Tokusumi; Yumiko Tokusumi; Dawn W. Hopkins; Douglas A. Shoue; Lauren Corona; Robert A. Schulz Bag of Marbles (Bam) is a stem cell differentiation factor in the Drosophila germ line. Here, we demonstrate that Bam has a crucial function in the lymph gland, the tissue that orchestrates...

... that Twin controls germ line cyst development by regulating poly(A) tail lengths of several targets including Cyclin A ( CycA ) RNA. twin mutants exhibit very low expression of Bag-of-marbles (Bam), a regulator of cyst division, indicating that Twin/Ccr4 activity is necessary for wild-type Bam expression...

... that gives rise to both a GSC,which remains associated with the CpCs, and a more posterior located cystoblast (CB). The CB upregulates expression of the novel gene, bag of marbles ( bam ), which is necessary for germline differentiation. Decapentaplegic (Dpp), a BMP2/4 homologue, has been postulated to act...

... act on GSCs and control their maintenance. In GSCs defective in Bmp signaling,expression of bam is upregulated, whereas forced bam expression in GSCs causes the GSCs to be lost. This study demonstrates that Bmp signals from the somatic cells maintain GSCs, at least in part, by repressing bam...

... that embark on the differentiation program specific for the given lineage. Spermatogenesis in Drosophila is a model system to identify molecules regulating stem cell lineages. Mutations at two previously identified loci, bag-of-marbles ( bam ) and benign gonial cell neoplasm ( bgcn ), prevent progression...

...Benjamin Ohlstein; Dennis McKearin ABSTRACT The Drosophila germ-cell lineage has emerged as a remark-able system for identifying genes required for changes in cell fate from stem cells into more specialized cells. Previous work indicates that bam expression is necessary for cystoblast...