1-20 of 45
Keywords: BMP4
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2022) 149 (1): dev200021.
Published: 12 January 2022
... negatively on epithelial expression of Shh and its mesenchymal effector gene Bmp4 . Activation of SHH or BMP4 signaling largely rescued the cellular defects of mutant ureters in explant cultures. Conversely, inhibition of SHH or BMP signaling in wild-type ureters recapitulated the mutant phenotype in a dose...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev178723.
Published: 17 October 2019
..., including sustained upregulation of Bmp4 expression and the inability of mutant epicardial cells to transition into a mature squamous phenotype. We identified Bmp4 as a transcriptional target of Wt1, thus providing a molecular basis for the retention of the cuboidal cell shape observed in the Wt1KO...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (4): dev161075.
Published: 23 February 2018
..., it binds a gene cohort involved in primitive streak formation at gastrulation, including NODAL , BMP4 and WNT3 . Comparing TCF7L1-bound sites with those bound by the WNT signaling effector β-catenin indicates that TCF7L1 acts largely on the WNT signaling pathway. TCF7L1 overlaps less with the pluripotency...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1296–1306.
Published: 1 April 2017
... and function were explored in early porcine embryos. Notably, siRNA-mediated gene knockdown and lentivirus-mediated TE-specific gene regulation demonstrated that CDX2 is essential for the maintenance of blastocyst integrity by regulating the BMP4-mediated blastocyst niche and classic protein kinase C (PKC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4608–4619.
Published: 15 December 2016
... cell death that includes mesodermal progenitor cells that have begun to precociously differentiate into cartilage cells. We propose that PRMT5 maintains progenitor cells through its regulation of Bmp4 . Intriguingly, adult and embryonic stem cells also require PRMT5 for maintaining pluripotency...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3383–3393.
Published: 1 October 2015
... stratification. We also discovered that Bmp4 is upregulated in the absence of β-catenin in keratocytes, which further triggers ERK1/2 (Mapk3/1) and Smad1/5 phosphorylation and enhances transcription factor p63 (Trp63) expression in mouse corneal basal epithelial cells and in a human corneal epithelial cell line...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1831–1839.
Published: 15 May 2015
... the BMP4 pathway is required for their differentiation. These findings establish an alternative model for patella development and provide the mechanical and molecular mechanisms that underlie this process. More broadly, our finding that activation of a joint formation program can be used to switch between...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (23): 4709–4718.
Published: 1 December 2013
... in palatal epithelial cells, indicating that Pax9 plays a crucial role in the mesenchyme-epithelium interactions during palate development. We found that expression of the Bmp4, Fgf10, Msx1 and Osr2 genes is significantly downregulated in the developing palatal mesenchyme in Pax9 mutant embryos. Remarkably...
Journal Articles
Journal: Development
Development (2013) 140 (22): 4533–4543.
Published: 15 November 2013
... a transient region in the anterior-proximal side of the embryo at E7.0 that possesses the ability to become neural or epidermal ectoderm in response to the absence or presence of BMP4, respectively. Furthermore, we demonstrated that inhibition of Nodal signaling could direct the pluripotent E6.5 epiblast...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (19): 3965–3976.
Published: 1 October 2013
... trophoblast following BMP4 treatment in the presence of feeder-conditioned media; however, this model has not been widely accepted, in part owing to a lack of proof for a trophoblast progenitor population. We have previously shown that p63, a member of the p53 family of nuclear proteins, is expressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2697–2702.
Published: 1 July 2013
...Irfan Saadi; Pragnya Das; Minglian Zhao; Lakshmi Raj; Intan Ruspita; Yan Xia; Virginia E. Papaioannou; Marianna Bei Bmp4 expression is tightly regulated during embryonic tooth development, with early expression in the dental epithelial placode leading to later expression in the dental mesenchyme...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2680–2690.
Published: 1 July 2013
... that a distinct pool of Sox9 - and Scx -positive progenitors forms these superstructures. We demonstrate that TGFβ signaling is necessary for the specification of bone eminence progenitors, whereas the SCX/BMP4 pathway is required for the differentiation of these progenitors to eminence-forming cells. Our...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (2): 423–432.
Published: 15 January 2013
...Shihai Jia; Jing Zhou; Yang Gao; Jin-A Baek; James F. Martin; Yu Lan; Rulang Jiang Previous studies have suggested that Bmp4 is a key Msx1-dependent mesenchymal odontogenic signal for driving tooth morphogenesis through the bud-to-cap transition. Whereas all tooth germs were arrested at the bud...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4499–4509.
Published: 15 October 2011
... ( cspg2, fibulin 1, tbx2b, bmp4 ) is expanded and endocardial cells along the extended tube-like structure exhibit characteristics of AV cells ( has2, notch1b and Alcam expression, cuboidal cell shape). Inhibition of has2 in npnt morphants rescues the endocardial, but not the myocardial, expansion...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (15): 3169–3177.
Published: 1 August 2011
...-catenin signaling and their downstream targets. (f) BMP4, primarily expressed in epithelium, acts as an autocrine factor to regulate epithelial proliferation and, secondarily, branching, through activation of BMPR1A (ALK3). (g) FGF-WNT/β-catenin signaling in the SEM and SMM negatively regulates Noggin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (18): 3025–3035.
Published: 15 September 2010
... in the Notch-interaction domain of Jag2 presented a variety of severe dental abnormalities. In molars, the crown morphology was misshapen, with additional cusps being formed. This was due to alterations in the enamel knot, an epithelial signalling structure involved in molar crown morphogenesis, in which Bmp4...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (13): 2095–2105.
Published: 1 July 2010
... differentiation. However, it remains unclear when and how BMP signaling executes those different functions during neural commitment. Here, we show that a BMP4-sensitive window exists during ESC neural differentiation. Cells at this specific period correspond to the egg cylinder stage epiblast and can...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (23): 3891–3901.
Published: 1 December 2008
... to specific BMP ligands. In this study, we have taken advantage of two follistatin-like genes ( fstl1 and fstl2 ), as well as a transgenic zebrafish line carrying an inducible truncated form of the BMP-type 1 receptor to study the role of Bmp4 outside of the context of DV specification. Characterization...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (13): 2311–2319.
Published: 1 July 2008
... and Bmp4 are expressed in a definite pattern, functions as an organizing center for lower-jaw development. In our experimental design, the extra source of Shh activates Fgf8, Bmp4 and Shh genes in caudal BA1 ectoderm in a spatial pattern similar to that of the oral epithelium, and regularly leads...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (8): 1525–1535.
Published: 15 April 2008
... a specific lineage. Here, we define in serum-free media the minimal factor requirement controlling each step of the differentiation process, resulting in the production of highly enriched hematopoietic progenitors. Four factors -Bmp4, activin A, bFGF (Fgf2) and VEGF (VegfA) - are sufficient to drive...
Includes: Supplementary data