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Keywords: BMP2
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Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (13): dev163378.
Published: 2 July 2018
... Bmp2 expression in the mouse chamber myocardium changes the transcriptional signature of adjacent chamber endocardial cells into valve tissue, and enables them to undergo epithelial-mesenchyme transition. This induction is independent of valve myocardium specification and requires high levels of Notch1...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (13): 2398–2409.
Published: 1 July 2016
... and impaired astrocytic proliferation and, consequently, death of neocortical neurons. Mechanistically, YAP was activated by BMP2, and the active/nuclear YAP was crucial for BMP2 induction and stabilization of SMAD1 and astrocytic differentiation. Expression of SMAD1 in YAP-deficient NSCs partially rescued...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (4): 551–559.
Published: 15 February 2010
... this endogenous regeneration model in neonatal mice, we have found that noggin treatment inhibits regeneration, thus suggesting a bone morphogenetic protein (BMP) requirement. Using non-regenerating amputation wounds, we show that BMP7 or BMP2 can induce a regenerative response. BMP-induced regeneration involves...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (7): 1499–1509.
Published: 1 April 2005
.... J. Morphol. 88 , 49 -92. Harris, M. P., Fallon, J. F. and Prum, R. O. ( 2002 ). Shh-Bmp2 signaling module and the evolutionary origin and diversification of feathers. J. Exp. Zool. 294 , 160 -176. Hirobe, T. ( 1995 ). Structure and function of melanocytes: microscopic morphology...
Journal Articles
Journal: Development
Development (2004) 131 (18): 4581–4592.
Published: 15 September 2004
... Bmp2 and Bmp7 expression in Hoxa13 mutant limbs. Biochemical analyses identified a novel series of Bmp2 and Bmp7 enhancer regions that directly interact with the HOXA13 DNA-binding domain and activate gene expression in the presence of HOXA13. Immunoprecipitation of HOXA13- Bmp2 and HOXA13- Bmp7...
Journal Articles
Journal: Development
Development (2004) 131 (17): 4201–4211.
Published: 1 September 2004
... crista that corresponds to the Bone morphogenetic protein 2 ( Bmp2 )-positive domain in the canal pouch. Using retroviruses or beads to increase Fibroblast Growth Factors (FGFs) for gain-of-function and beads soaked with the FGF inhibitor SU5402 for loss-of-function experiments,we show that FGFs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (21): 5203–5215.
Published: 1 November 2003
... ephrin A5 by a DNA binding-dependent mechanism, ephrin A2 by a DNA binding-independent mechanism, and CBF2, SOHo1, GH6 and EphA3 by dual mechanisms. BMP2 expression begins double-gradiently in the retina from E5 in a complementary pattern to Ventroptin expression. Ventroptin antagonizes BMP2 as well...
Journal Articles
Journal: Development
Development (2001) 128 (12): 2269–2279.
Published: 15 June 2001
... drawn in studies based on these maps. We present accurate fate maps of the heart-forming region (HFR) in avian embryos and show that the putative cardiogenic molecular markers Bmp2 and Nkx2.5 do not govern the boundaries of the HFR as suggested in the literature. Moreover, this paper presents the first...
Journal Articles
Journal: Development
Development (2000) 127 (5): 1105–1114.
Published: 1 March 2000
...Lynne M. Angerer; David W. Oleksyn; Catriona Y. Logan; David R. McClay; Leslie Dale; Robert C. Angerer ABSTRACT To examine whether a BMP signaling pathway functions in specification of cell fates in sea urchin embryos, we have cloned sea urchin BMP2/4, analyzed its expression in time and space...
Journal Articles
Journal: Development
Development (2000) 127 (5): 1095–1104.
Published: 1 March 2000
...Benoît Kanzler; Ruth K. Foreman; Patricia A. Labosky; Moisés Mallo ABSTRACT BMP signaling is essential for a wide variety of developmental processes. To evaluate the role of Bmp2/4 in cranial neural crest (CNC) formation or differentiation after its migration into the branchial arches, we used...
Journal Articles
Journal: Development
Development (1999) 126 (16): 3545–3559.
Published: 15 August 1999
... challenged with BMP2, a factor that induces autonomic neurogenesis in many other cells in the explants. Moreover, BMP2 fails to prevent expression of the sensory-specific basic helix-loop-helix (bHLH) transcription factors neurogenin1, neurogenin2 and neuroD , although it induces expression of the autonomic...
Journal Articles
Journal: Development
Development (1999) 126 (3): 535–546.
Published: 1 February 1999
..., 279-287). Here we show that Bmp2 and Bmp4 are expressed in PSA1 embryoid bodies and embryos at the stages when visceral endoderm differentiation and cavitation are occurring, and that blocking BMP signaling via expression of a transgene encoding a dominant negative mutant form of BMP receptor IB...
Journal Articles
Journal: Development
Development (1999) 126 (1): 63–73.
Published: 1 January 1999
... to the generation of epidermis, and to the inhibition of neuroepithelium in the naked ectoderm. This suggests a signal necessary for neural, but inhibitory for epidermal development, normally coming from the lower layers. Finally, we demonstrate that BMP4, as well as BMP2, is capable of inducing epidermal fate...
Journal Articles
Journal: Development
Development (1998) 125 (7): 1241–1251.
Published: 1 April 1998
...-E18) and postnatal stages (P1-P6). Msx1 and Msx2 were expressed in the sutural mesenchyme and the dura mater. FGFR2(BEK) , as well as Bmp2 and Bmp4 , were intensely expressed in the osteogenic fronts and Bmp4 also in the mesenchyme of the sagittal suture and in the dura mater. Fgf9 was expressed...
Journal Articles
Journal: Development
Development (1997) 124 (22): 4457–4466.
Published: 15 November 1997
... in the zebrafish bmp2 gene ( zbmp2 ). While injection of mRNAs encoded by the mutant alleles has no ventralizing effect, injection of wild-type zbmp2 mRNA leads to a complete rescue of the swirl mutant phenotype. Fertile adult mutant fish were obtained, showing that development after gastrulation is not dependent...
Journal Articles
Journal: Development
Development (1997) 124 (21): 4253–4264.
Published: 1 November 1997
... of these factors in the ventral part of the embryo as early as blastula stage, suggesting that FGF8 acts upstream of BMP2 and BMP4. We conclude that FGF-8 is involved in defining dorsoventral identity and is an important organizing factor responsible for specification of mesodermal and ectodermal dorsolateral...
Journal Articles
Journal: Development
Development (1996) 122 (10): 2977–2986.
Published: 1 October 1996
...Hongbing Zhang; Allan Bradley ABSTRACT To address the function of bone morphogenetic protein-2 (BMP2) in mammalian development, mice with a targeted deletion of the Bmp2 mature region were generated using embryonic stem cell technology. This mutation caused embryonic lethality when homozygous...