...-propeptide of procollagen I, II and III. BMP-1 is also related to the product of the Drosophila patterning gene, tolloid (tld) , which enhances the activity of the TGFβ-related growth factor Decapentaplegic and promotes deveopment of the dorsalmost amnioserosa. We have disrupted the mouse Bmp1 gene...

... of the tolloid /BMP-1 family in Drosophila, tolkin , which has the same overall structure as tolloid , but exhibits more homology to BMP-1 (A. L. F. and R. W. P., unpublished data). Although we are uncertain of tolkin’ s function, it may interact with dpp at a later developmental stage, be involved...

... domains as the human bone morphogenetic protein BMP-1, a protease described as a factor involved in bone formation, and as the recently characterized product of the tolloid gene which is required for correct dorsal-ventral patterning of the Drosophila embryo. The transcription of the BP10 gene...