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Keywords: BMP signaling
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Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2024) 151 (4): dev202316.
Published: 19 February 2024
...Alexandra Schauer; Kornelija Pranjic-Ferscha; Robert Hauschild; Carl-Philipp Heisenberg ABSTRACT Embryogenesis results from the coordinated activities of different signaling pathways controlling cell fate specification and morphogenesis. In vertebrate gastrulation, both Nodal and BMP signaling play...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (15): dev201734.
Published: 4 August 2023
... and reduced skeletal growth in juvenile mice. Overall, we conclude that Wnt7b is a crucial factor secreted from hypertrophic chondrocytes to initiate endochondral ossification. These results suggest that Smad4-dependent BMP signaling regulates the Wnt7b–β-catenin axis during endochondral ossification...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (3): dev199890.
Published: 4 February 2022
...Leslie Dunipace; Susan Newcomb; Angelike Stathopoulos ABSTRACT A limited BMP signaling range in the stem cell niche of the ovary protects against germ cell tumors and promotes germ cell homeostasis. The canonical repressor of BMP signaling in both the Drosophila embryo and wing disc...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (13): dev196519.
Published: 1 July 2021
... pSer-19-mediated MLC2 contractility. The compressive stress acts through BMP signaling to increase cell proliferation and decrease cell contractility, and MEK-ERK is essential for both compressive stress and BMP mediation of compaction. We further showed that the effects of osmotic stress are conserved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev179093.
Published: 17 October 2019
.... , Unger , C. and Andrews , P. W. ( 2017 ). Top-down inhibition of BMP signaling enables robust induction of hPSCs into neural crest in fully defined, xeno-free conditions . Stem Cell Rep.   9 , 1043 - 1052 . 10.1016/j.stemcr.2017.08.008 Heemskerk , I. , Burt , K. , Miller , M...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev164103.
Published: 21 March 2019
... erythropoiesis, encodes a C2H2 zinc-finger protein that inhibits BMP signaling. We therefore named this gene blood-inducing factor 1 and BMP inhibitory factor 1 ( bif1 ). We identified a bif1 ortholog in Sinocyclocheilus rhinocerous , another fish, and in the mouse genome. Both genes also inhibit BMP signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev166017.
Published: 15 February 2019
... . Rajaram , S. , Patel , S. , Uggini , G. K. , Desai , I. and Balakrishnan , S. ( 2017 ). BMP signaling regulates the skeletal and connective tissue differentiation during caudal fin regeneration in sailfin molly (Poecilia latipinna) . Dev. Growth Differ.   59 , 629 - 638 . 10.1111...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (20): dev166710.
Published: 26 October 2018
... regulates BMP signaling. From these results, we conclude that Fam46a is required for PPE formation via the positive regulation of BMP signaling. Our study provides a new mechanism of ectodermal patterning via cell-autonomous regulation of BMP signaling in the PPE. * Present address: National...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154047.
Published: 3 January 2018
... remodeling and further elucidate how Shep regulates transcription of its chromatin targets to regulate neuronal remodeling. shep Neuronal transcriptome Metamorphosis Neuronal remodeling BMP signaling Chromatin insulator The nervous system is highly dynamic during development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2982–2993.
Published: 15 August 2017
... under the action of the segmentation clock. The signals responsible for tailbud mesoderm progenitor pool maintenance during axial elongation are still elusive. Here, we show that Bmp signaling is sufficient to activate the entire mesoderm progenitor gene signature in primary cultures of caudal mesoderm...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (16): 3002–3011.
Published: 15 August 2016
... affecting EE tissue specification or maintenance. These macroevolutionary changes in function between Tribolium and Drosophila are accompanied by regulatory network changes, where BMP signaling and possibly the transcription factor Hindsight are downstream mediators. We propose that the ancestral role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 2000–2011.
Published: 1 June 2016
..., including the Bone morphogenetic protein (Bmp) pathway. However, the role of Bmp signaling in pouch morphogenesis is poorly understood. Using genetic and chemical inhibitor approaches, we show that pouch morphogenesis requires Bmp signaling from 10-18 h post-fertilization, immediately following gastrulation...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (10): 1767–1776.
Published: 15 May 2015
... in cardiomyocyte numbers. Cell-tracing experiments, using photoconvertable fluorescent proteins and genetic labeling, demonstrate that Gpc4 ‘Knypek’ is required for specification of cardiac progenitor cells and their differentiation into cardiomyocytes. Mechanistically, we show that Bmp signaling is enhanced...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (19): 4070–4080.
Published: 1 October 2013
...Chenxi Tian; Herong Shi; Shan Xiong; Fenghua Hu; Wen-Cheng Xiong; Jun Liu The deleted in colorectal cancer (DCC) homolog neogenin functions in both netrin- and repulsive guidance molecule (RGM)-mediated axon guidance and in bone morphogenetic protein (BMP) signaling. How neogenin functions...
Includes: Supplementary data