... that they also share gene expression profiles with vertebrate anterior neural tissue and cranial placodes, their study should shed light on the emergence of the unique vertebrate telencephalon. We show that BMP signaling regulates two phases of palp formation in Ciona intestinalis . During gastrulation...

... are a predominant cause of congenital thyroid diseases. The first molecularly recognizable step of thyroid development is the specification of thyroid precursors in anterior foregut endoderm. Recent studies have identified crucial roles of FGF and BMP signaling in thyroid specification, but the interplay between...

...Julie Gamart; Iros Barozzi; Frédéric Laurent; Robert Reinhardt; Laurène Ramos Martins; Thomas Oberholzer; Axel Visel; Rolf Zeller; Aimée Zuniga ABSTRACT SMAD4 regulates gene expression in response to BMP and TGFβ signal transduction, and is required for diverse morphogenetic processes, but its...

...Mari Ichinose; Nobumi Suzuki; Tongtong Wang; Hiroki Kobayashi; Laura Vrbanac; Jia Q. Ng; Josephine A. Wright; Tamsin R. M. Lannagan; Krystyna A. Gieniec; Martin Lewis; Ryota Ando; Atsushi Enomoto; Simon Koblar; Paul Thomas; Daniel L. Worthley; Susan L. Woods ABSTRACT Bone morphogenetic protein (BMP...

... degenerate and the Wolffian ducts differentiate into vas deferens, epididymis and seminal vesicle. The degeneration of the Müllerian ducts in males are ascribed to apoptotic effect of anti-Müllerian hormone (AMH), a BMP subfamily member that is secreted by Sertoli cells in the developing testis ( Klattig...

..., is identified as a master gene in hindbrain choroid plexus patterning and multiciliogenesis. Choroid plexus Patterning Development Hindbrain Wnt BMP Cilium Multiciliated cells Multiciliated epithelium Microvilli Zfp423 ZNF423 Joubert syndrome JS19 Hydrocephalus The choroid plexus...

...Alexis R. Lanza; Elaine C. Seaver ABSTRACT The TGF-β superfamily comprises two distinct branches: the Activin/Nodal and BMP pathways. During development, signaling by this superfamily regulates a variety of embryological processes, and it has a conserved role in patterning the dorsal-ventral body...

... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages...

..., we use the BMP signaling inhibitor LDN193189 on Ambystoma mexicanum to explore the role of BMPs in regeneration. We find that BMP signaling is required for proper expression of various patterning genes and that its inhibition causes major defects in the regenerated limbs. Fgf8 is downregulated when...

... ). In addition, the nascent DM controls the timing of neural crest delamination by modulating noggin mRNA and BMP activity in the NT ( Sela-Donenfeld and Kalcheim, 2000 ). Reciprocally, Bmp4 and/or Wnt1 from the NT pattern somite-derived myogenesis ( Abu-Elmagd et al., 2010 ; Marcelle et al., 1997...

... protein (BMP) signal transduction in postnatal mice, with BMP signaling being restricted to basal VSNs and at the marginal zones of the VNO: the site of neurogenesis. Using different Smad4 conditional knockout mouse models, we disrupted canonical TGFβ/BMP signaling in either maturing basal VSNs (bVSNs...

... between GSCs and daughter cells, and overproliferation of GSC progeny. Mechanistically, Wh interacts with Mei-p26 in different cellular contexts to induce cell type-specific effects. In GSCs, Wh and Mei-p26 promote BMP stemness signaling for proper GSC division and maintenance. In GSC progeny, Wh and Mei...

... School) entitled ‘Morphogenetic control of zebrafish cardiac looping by Bmp signaling’. Author contributions Conceptualization: V.A.L., M.H., J.M., S.A.-S.; Methodology: V.A.L., M.H., M.M., D.B., S.A.-S.; Software: V.A.L., M.H., M.M.; Validation: V.A.L., M.H., S.A.-S.; Formal analysis: V.A.L...

.... Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative in vivo imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that Bmp signaling and the actomyosin cytoskeleton promote constriction of the DP, which enables...

... , J. and Keller , G. ( 2011 ). Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines . Cell Stem Cell   8 , 228 - 240 . 10.1016/j.stem.2010.12.008 Kubalak , S. W. , Miller-Hance , W. C...

... programs is applied to achieve anatomical and ultimately functional variation during sesamoid bone development. Sesamoid bone Joint Sox9 Scleraxis Tgfβ BMP Mouse Sesamoid bones constitute a special group of bones that are integral to the skeletons of many vertebrate species ( Abdala et...

... in mutants that have lost the energy sensor AMP-activated protein kinase (AMPK) or the insulin/IGF-1 signaling (IIS) negative regulator DAF-18/PTEN. We report that DBL-1/BMP works upstream of IIS to promote agonistic insulin-like peptides during L1 arrest. However, the abnormal Q cell divisions that occur...

... descend from scleraxis- and Sox9-expressing progenitors; however, Hyp entheses exhibit an expansion of Sox9-expressing cells, and enhanced BMP and IHH signaling. These results support a role for enhanced BMP and IHH signaling in the development of enthesopathy in XLH. * Author for correspondence...

... , O. , Zaragosi , L.-E. , Barbry , P. , Pasini , A. , Marcet , B. and Kodjabachian , L. ( 2015 ). BMP signalling controls the construction of vertebrate mucociliary epithelia . Development   142 , 2352 - 2363 . 10.1242/dev.118679 Coffman , C. , Harris , W...

...Mei-I Chung; Melissa Bujnis; Christina E. Barkauskas; Yoshihiko Kobayashi; Brigid L. M. Hogan ABSTRACT The bone morphogenetic protein (BMP) signaling pathway, including antagonists, functions in lung development and regeneration of tracheal epithelium from basal stem cells. Here, we explore its...