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Keywords: BMP
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Journal Articles
Journal: Development
Development (2023) 150 (23): dev202168.
Published: 7 December 2023
... inhibited tooth formation. Thus, similar to known roles in hair regeneration, Wnt and BMP signals promote and inhibit regeneration, respectively. Regulation of total tooth number was separable from regulation of replacement rates. RNA sequencing of stickleback dental tissue showed that Bmp6 overexpression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (22): dev202140.
Published: 20 November 2023
... in the oral epithelium. Building on previous knowledge, we explored the hair-inductive ability of the Wnt agonist R-spondin 1 and a Bmp receptor inhibitor in embryonic skin explants. Although R-spondin 1 instigated precocious placode-specific transcriptional responses, it was insufficient for hair follicle...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (21): dev201811.
Published: 3 November 2023
...Molly R. Kulikauskas; Morgan Oatley; Tianji Yu; Ziqing Liu; Lauren Matsumura; Elise Kidder; Dana Ruter; Victoria L. Bautch ABSTRACT BMP signaling is crucial to blood vessel formation and function, but how pathway components regulate vascular development is not well-understood. Here, we find...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2023) 150 (10): dev201575.
Published: 22 May 2023
... that they also share gene expression profiles with vertebrate anterior neural tissue and cranial placodes, their study should shed light on the emergence of the unique vertebrate telencephalon. We show that BMP signaling regulates two phases of palp formation in Ciona intestinalis . During gastrulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (10): dev201023.
Published: 16 May 2023
... are a predominant cause of congenital thyroid diseases. The first molecularly recognizable step of thyroid development is the specification of thyroid precursors in anterior foregut endoderm. Recent studies have identified crucial roles of FGF and BMP signaling in thyroid specification, but the interplay between...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (5): dev188490.
Published: 12 March 2021
... degenerate and the Wolffian ducts differentiate into vas deferens, epididymis and seminal vesicle. The degeneration of the Müllerian ducts in males are ascribed to apoptotic effect of anti-Müllerian hormone (AMH), a BMP subfamily member that is secreted by Sertoli cells in the developing testis ( Klattig...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (22): dev190173.
Published: 30 November 2020
..., is identified as a master gene in hindbrain choroid plexus patterning and multiciliogenesis. Choroid plexus Patterning Development Hindbrain Wnt BMP Cilium Multiciliated cells Multiciliated epithelium Microvilli Zfp423 ZNF423 Joubert syndrome JS19 Hydrocephalus The choroid plexus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev189373.
Published: 23 September 2020
...Alexis R. Lanza; Elaine C. Seaver ABSTRACT The TGF-β superfamily comprises two distinct branches: the Activin/Nodal and BMP pathways. During development, signaling by this superfamily regulates a variety of embryological processes, and it has a conserved role in patterning the dorsal-ventral body...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188839.
Published: 15 September 2020
... give rise to zymogenic cells in culture. Modulating the activity of the WNT, BMP and Notch pathways in vivo and ex vivo , we found that WNTs are essential for the maintenance of Lgr5 + epithelial cells. Notch prevents differentiation of the embryonic epithelial cells along all secretory lineages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev170829.
Published: 31 July 2020
..., we use the BMP signaling inhibitor LDN193189 on Ambystoma mexicanum to explore the role of BMPs in regeneration. We find that BMP signaling is required for proper expression of various patterning genes and that its inhibition causes major defects in the regenerated limbs. Fgf8 is downregulated when...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev183996.
Published: 26 May 2020
... ). In addition, the nascent DM controls the timing of neural crest delamination by modulating noggin mRNA and BMP activity in the NT ( Sela-Donenfeld and Kalcheim, 2000 ). Reciprocally, Bmp4 and/or Wnt1 from the NT pattern somite-derived myogenesis ( Abu-Elmagd et al., 2010 ; Marcelle et al., 1997...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (2): dev182063.
Published: 15 January 2020
... between GSCs and daughter cells, and overproliferation of GSC progeny. Mechanistically, Wh interacts with Mei-p26 in different cellular contexts to induce cell type-specific effects. In GSCs, Wh and Mei-p26 promote BMP stemness signaling for proper GSC division and maintenance. In GSC progeny, Wh and Mei...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180091.
Published: 14 November 2019
... School) entitled ‘Morphogenetic control of zebrafish cardiac looping by Bmp signaling’. Author contributions Conceptualization: V.A.L., M.H., J.M., S.A.-S.; Methodology: V.A.L., M.H., M.M., D.B., S.A.-S.; Software: V.A.L., M.H., M.M.; Validation: V.A.L., M.H., S.A.-S.; Formal analysis: V.A.L...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174961.
Published: 4 July 2019
.... Using a zebrafish model and a combination of genetic tools, pharmacological agents and quantitative in vivo imaging, we reveal that a coordinated collective movement of DP cells drives PE formation. We found that Bmp signaling and the actomyosin cytoskeleton promote constriction of the DP, which enables...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev172619.
Published: 8 May 2019
... , J. and Keller , G. ( 2011 ). Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines . Cell Stem Cell   8 , 228 - 240 . 10.1016/j.stem.2010.12.008 Kubalak , S. W. , Miller-Hance , W. C...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev167452.
Published: 28 February 2019
... programs is applied to achieve anatomical and ultimately functional variation during sesamoid bone development. Sesamoid bone Joint Sox9 Scleraxis Tgfβ BMP Mouse Sesamoid bones constitute a special group of bones that are integral to the skeletons of many vertebrate species ( Abdala et...
Includes: Supplementary data