... in the kinesin-1 molecular motor have been identified in patients with abnormal cortical development and impaired white matter integrity, we studied the defects in axonal pathfinding and fasciculation in mice lacking the kinesin light chain 1 (Klc1 −/−) subunit of kinesin-1. Reduced levels of CB1R were found...

...Torsten Bossing; Andrea H. Brand Ephrin/Eph signalling is crucial for axonal pathfinding in vertebrates and invertebrates. We identified the Drosophila ephrin orthologue, Dephrin, and describe for the first time the role of ephrin/Eph signalling in the embryonic central nervous system (CNS...

.../hindbrain domain, in cell proliferation and survival, in neurite formation, tissue polarization and axonal pathfinding. We have analyzed the consequences of a local gain of En function within or adjacent to the endogenous expression domain in mouse and chick embryos. In WEXPZ.En1 transgenic mice (Danielian...

... by Company of Biologists 1998 Nervous system Cell migration Axonal pathfinding Drosophila Epithelium The development of the nervous system involves highly ordered cell movements. One of the earliest of these events is the segregation of neural progenitors in a reproducible...

... essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. * Author for correspondence (e-mail: [email protected]) 03 01 1998 18 03 1998 © 1998 by Company of Biologists 1998 Caenorhabditis elegans Transcription unc-3 Axonal...

... and vertebrates, growth cones follow distinct pathways resulting in reproducible axonal patterns (reviewed by Goodman and Shatz, 1993). This precision arises, at least inpart, because only particular regions of the embryo are permissive for axonal pathfinding (see Tosney, 1992). In the Drosophila melanogaster...

... and axonal pathfinding mutants. During embryogenesis, two bilaterally symmetrical cephalic neurogenic regions form, which are initially separated from each other and from the ventral nerve cord. The brain commissure that interconnects the two brain hemispheres is pioneered by axons that project towards...

... 1992 cerebral cortex cortex development axonal pathfinding slice cultures rat thalamic innervation The establishment of specific connections between neuronal populations and their distant target areas involves several steps. Growing axons have to find the correct pathways in order...

... by Company of Biologists 1991 growth cone guidance axonal pathfinding pineal brain development pioneer neurons zebrafish epiphysis growth cone morphology Table 1. Analysis of number of growth cone processes in different regions of the pathway Upon contacting the TPOC (Fig. 5E-G...