... in the kinesin-1 molecular motor have been identified in patients with abnormal cortical development and impaired white matter integrity, we studied the defects in axonal pathfinding and fasciculation in mice lacking the kinesin light chain 1 ( Klc1 −/− ) subunit of kinesin-1. Reduced levels of CB1R were found...

...Torsten Bossing; Andrea H. Brand Ephrin/Eph signalling is crucial for axonal pathfinding in vertebrates and invertebrates. We identified the Drosophila ephrin orthologue, Dephrin, and describe for the first time the role of ephrin/Eph signalling in the embryonic central nervous system (CNS...

.../hindbrain domain, in cell proliferation and survival, in neurite formation, tissue polarization and axonal pathfinding. We have analyzed the consequences of a local gain of En function within or adjacent to the endogenous expression domain in mouse and chick embryos. In WEXPZ.En1 transgenic mice (Danielian...

...: Department of Pharmacology, Box 357750, University of Washington, Seattle, WA 98195, USA † Current address: Department of Zoology, University of Toronto, Toronto, Ontario, Canada, M55 3G5 Fig. 7. Defects in neural morphogenesis and axonal pathfinding in fas mutant embryo. Top panel...

... essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. * Author for correspondence (e-mail: rreed@jhmi.edu ) 03 01 1998 18 03 1998 © 1998 by Company of Biologists 1998 Caenorhabditis elegans Transcription unc-3 Axonal...

... of Biologists 1992 cerebral cortex cortex development axonal pathfinding slice cultures rat thalamic innervation The establishment of specific connections between neuronal populations and their distant target areas involves several steps. Growing axons have to find the correct pathways...