.... Amyloid precursor protein Neural development Axonal outgrowth Synapse formation Alzheimer's disease (AD) is characterized by a progressive degeneration of neurons, which results in cognitive deficiency, behavioral disturbance and neuropsychiatric symptoms ( Adlard and Cummings, 2004 ). AD...

..., however, remain unclear. Here, we report the identification and characterization of a zebrafish kbp mutant. We show that kbp is required for axonal outgrowth and maintenance. In vivo time-lapse analysis of neuronal development shows that the speed of early axonal outgrowth is reduced in both...

... migration axonal outgrowth C. elegans canal associated neurons Cell migration and axonal outgrowth play important roles in shaping form and pattern during development. The migrations of growth cones, for example, contribute to the final pattern of connectivity that is essential for nervous...

... © 1993 by Company of Biologists 1993 C. elegans axonal outgrowth axonal branching fasciculation A major goal in developmental neurobiology is to under-stand how neurites navigate to find their synaptic partners. What types of cells guide neurites to their targets? What...

... is initially confined to perikarya of postmitotic migratory ganglion cells of the embryonic chick retina as revealed by bromodeoxyuridine labeling. During the subsequent period of axon outgrowth, the antigen becomes restricted to ganglion cell axons but disappears during the innervation of the tectum opticum...