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Keywords: Axon pathfinding
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (6): dev174300.
Published: 15 March 2019
...-Aliaga , I. , Allan , D. W. and Thor , S. ( 2004 ). Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification . Development   131 , 5837 - 5848 . 10.1242/dev.01447 Park , D. and Taghert , P. H. ( 2009...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3435–3444.
Published: 15 August 2013
..., we compared the phenotypes of rin-1 mutants with those of ced-10 mutants. ced-10 mutant animals showed various defects related to cytoskeletal regulation, such as abnormalities in cell migration, axon pathfinding of neurons and phagocytosis. First, we analyzed axon outgrowth of the AVM neuron...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1535–1546.
Published: 1 May 2012
... Neuronal migration Neuronal identity Axon pathfinding Pyramidal neuron Neuronal circuits Cerebral cortex The cerebral cortex, an extensive sheet of neural tissue at the most superficial part of the cerebral hemispheres, is involved in a variety of higher cognitive, emotional...
Journal Articles
Journal: Development
Development (2008) 135 (2): 333–342.
Published: 15 January 2008
... growth cone responses and implicate S1P signalling in axon guidance. * Author for correspondence (e-mail: ceh@mole.bio.cam.ac.uk ) 17 10 2007 © 2008. 2008 Sphingosine 1-phosphate Retinal ganglion cell Axon pathfinding Growth cone Collapse Guidance cue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (18): 3259–3269.
Published: 15 September 2007
... mutations affecting different steps in the axonal pathfinding of these motoneurons. The class 1 mutations caused severe defasciculation and abnormal pathfinding in both Vp and VII motor axons before they reached their target muscles in BA1. The class 2 mutations caused impaired axonal outgrowth of the Vp...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (24): 4981–4991.
Published: 15 December 2006
... Smad2 (Smox) Motoneuron Axon pathfinding Neuromuscular system Glia During nervous system development, axons are guided by attractive and repulsive cues, allowing them to navigate through a complex extracellular environment to their final destinations. The accuracy of axon guidance, target...
Journal Articles
Journal: Development
Development (2006) 133 (8): 1445–1455.
Published: 15 April 2006
... homeobox gene. We find that ISN motoneurons also express the GATA transcription factor Grain, and grn mutants display motor axon pathfinding defects. Although these three regulators are expressed by all ISN motoneurons, these genes act in an eve→grn→zfh1 genetic cascade unique to one of the ISN motoneurons...
Journal Articles
Journal: Development
Development (2003) 130 (14): 3217–3226.
Published: 15 July 2003
... with the transmembrane protein Neurotactin(Nrt) to promote cell:cell adhesion. We have identified an unusual missense ama allele, ama M109 , which dominantly enhances the Abl mutant phenotype, affecting axon pathfinding. Heterozygous null alleles of ama do not show this dominant enhancement, but animals homozygous...
Journal Articles
Journal: Development
Development (2003) 130 (7): 1307–1316.
Published: 1 April 2003
... and molecular mechanisms by which olfactory axons pathfind to their targets are poorly understood. We report here that the SH2/SH3 adapter Dock and the serine/threonine kinase Pak are necessary for the precise guidance of olfactory axons. Using antibody localization, mosaic analyses and cell-type specific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (4): 693–704.
Published: 15 February 2003
...Eric C. Struckhoff; Erik A. Lundquist Rac GTPases control cell shape by regulating downstream effectors that influence the actin cytoskeleton. UNC-115, a putative actin-binding protein similar to human abLIM/limatin, has previously been implicated in axon pathfinding. We have discovered the role...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4475–4488.
Published: 15 November 2001
...Erik A. Lundquist; Peter W. Reddien; Erika Hartwieg; H. Robert Horvitz; Cornelia I. Bargmann The Caenorhabditis elegans genome contains three rac -like genes, ced-10, mig-2 , and rac-2 . We report that ced-10 , mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4585–4595.
Published: 15 November 2001
..., thereby ensuring that combinatorial codes of positive and negative growth signals are interpreted appropriately. *Author for correspondence (e-mail: mtiemeyer@glyko.com ) 16 8 2001 © 2001. 2001 Carbohydrate Lectin Axon pathfinding Glia Drosophila The formation...
Journal Articles
Journal: Development
Development (2001) 128 (15): 3029–3039.
Published: 1 August 2001
... blotting kit (Roche Diagnostics). *Author for correspondence (e-mail: foerster@uni-freiburg.de ) 9 5 2001 © 2001. 2001 Cell adhesion Hippocampus Entorhinal cortex Axon pathfinding Hyaluronan Rat In the hippocampus ingrowing afferents terminate in specific layers. Lamina...
Journal Articles
Journal: Development
Development (2001) 128 (15): 3041–3048.
Published: 1 August 2001
...Eric Birgbauer; Stephen F. Oster; Christophe G. Severin; David W. Sretavan Axon pathfinding relies on cellular signaling mediated by growth cone receptor proteins responding to ligands, or guidance cues, in the environment. Eph proteins are a family of receptor tyrosine kinases that govern axon...
Journal Articles
Journal: Development
Development (2001) 128 (13): 2421–2432.
Published: 1 July 2001
..., parvalbumin and Brn3b. Selective loss of TrkC neurons in the spiral ganglion of Brn3a −/− cochlea leads to an innervation defect similar to that of TrkC −/− mice. Most remarkably, our results uncover a novel role for Brn3a in regulating axon pathfinding and target field innervation by spiral and vestibular...