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Keywords: Axon pathfinding
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Journal Articles
Journal: Development
Development (2019) 146 (6): dev174300.
Published: 15 March 2019
... eyes absent genes in BMP signaling, axon pathfinding and neuronal specification . Development   131 , 5837 - 5848 . 10.1242/dev.01447 Park , D. and Taghert , P. H. ( 2009 ). Peptidergic neurosecretory cells in insects: organization and control by the bHLH protein DIMMED . Gen...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3435–3444.
Published: 15 August 2013
... GTPase Actin remodeling Axon pathfinding The spatiotemporal regulation of the activity and localization of small GTPases is determined by whether they are bound to GDP or GTP, and through interaction with effector proteins that specifically bind to the active form of the GTPase. GDP/GTP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1535–1546.
Published: 01 May 2012
... Neuronal migration Neuronal identity Axon pathfinding Pyramidal neuron Neuronal circuits Cerebral cortex The cerebral cortex, an extensive sheet of neural tissue at the most superficial part of the cerebral hemispheres, is involved in a variety of higher cognitive, emotional...
Journal Articles
Journal: Development
Development (2008) 135 (2): 333–342.
Published: 15 January 2008
... S1P-induced growth cone responses and implicate S1P signalling in axon guidance. * Author for correspondence (e-mail: ceh@mole.bio.cam.ac.uk ) 17 10 2007 © 2008. 2008 Sphingosine 1-phosphate Retinal ganglion cell Axon pathfinding Growth cone Collapse Guidance cue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (18): 3259–3269.
Published: 15 September 2007
... mutations affecting different steps in the axonal pathfinding of these motoneurons. The class 1 mutations caused severe defasciculation and abnormal pathfinding in both Vp and VII motor axons before they reached their target muscles in BA1. The class 2 mutations caused impaired axonal outgrowth of the Vp...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (24): 4981–4991.
Published: 15 December 2006
... - pathfinding defects (L.P. and K.A.,unpublished). However, an assessment of their roles in axon pathfinding must await the recovery of mutations in these genes. Furthermore, daw may have other functions in addition to embryonic pathfinding. A majority of daw mutants die during pupal stages despite the fact...
Journal Articles
Journal: Development
Development (2006) 133 (8): 1445–1455.
Published: 15 April 2006
... zinc-finger homeobox gene. We find that ISN motoneurons also express the GATA transcription factor Grain, and grn mutants display motor axon pathfinding defects. Although these three regulators are expressed by all ISN motoneurons, these genes act in an eve→grn→zfh1 genetic cascade unique to one of the...
Journal Articles
Journal: Development
Development (2003) 130 (14): 3217–3226.
Published: 15 July 2003
... transmembrane protein Neurotactin(Nrt) to promote cell:cell adhesion. We have identified an unusual missense ama allele, ama M109 , which dominantly enhances the Abl mutant phenotype, affecting axon pathfinding. Heterozygous null alleles of ama do not show this dominant enhancement, but animals homozygous...
Journal Articles
Journal: Development
Development (2003) 130 (7): 1307–1316.
Published: 01 April 2003
... molecular mechanisms by which olfactory axons pathfind to their targets are poorly understood. We report here that the SH2/SH3 adapter Dock and the serine/threonine kinase Pak are necessary for the precise guidance of olfactory axons. Using antibody localization, mosaic analyses and cell-type specific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (4): 693–704.
Published: 15 February 2003
...Eric C. Struckhoff; Erik A. Lundquist Rac GTPases control cell shape by regulating downstream effectors that influence the actin cytoskeleton. UNC-115, a putative actin-binding protein similar to human abLIM/limatin, has previously been implicated in axon pathfinding. We have discovered the role of...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4585–4595.
Published: 15 November 2001
..., thereby ensuring that combinatorial codes of positive and negative growth signals are interpreted appropriately. *Author for correspondence (e-mail: mtiemeyer@glyko.com ) 16 8 2001 © 2001. 2001 Carbohydrate Lectin Axon pathfinding Glia Drosophila The formation of a...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4475–4488.
Published: 15 November 2001
...Erik A. Lundquist; Peter W. Reddien; Erika Hartwieg; H. Robert Horvitz; Cornelia I. Bargmann The Caenorhabditis elegans genome contains three rac -like genes, ced-10, mig-2 , and rac-2 . We report that ced-10 , mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little...
Journal Articles
Journal: Development
Development (2001) 128 (15): 3029–3039.
Published: 01 August 2001
..., R. K. ( 1992 ). Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulphate proteoglycan of brain. J. Biol. Chem . 267 , 19536 -19547. Rauch, U. ( 1997 ) Modeling an extracellular environment for axonal pathfinding and fasciculation in the...
Journal Articles
Journal: Development
Development (2001) 128 (15): 3041–3048.
Published: 01 August 2001
...Eric Birgbauer; Stephen F. Oster; Christophe G. Severin; David W. Sretavan Axon pathfinding relies on cellular signaling mediated by growth cone receptor proteins responding to ligands, or guidance cues, in the environment. Eph proteins are a family of receptor tyrosine kinases that govern axon...
Journal Articles
Journal: Development
Development (2001) 128 (13): 2421–2432.
Published: 01 July 2001
... TrkC, parvalbumin and Brn3b. Selective loss of TrkC neurons in the spiral ganglion of Brn3a −/− cochlea leads to an innervation defect similar to that of TrkC −/− mice. Most remarkably, our results uncover a novel role for Brn3a in regulating axon pathfinding and target field innervation by spiral and...