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Keywords: Axon guidance
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Journal Articles
Journal: Development
Development (2020) 147 (20): dev196055.
Published: 29 October 2020
... sufficient to repel axons. However, longitudinal axon guidance is highly disrupted in tok mutants and can be rescued by midline expression of Slit-N, suggesting that Slit is the primary substrate for Tok in the embryonic CNS. Transgenic restoration of Slit-N or Slit-C does not repel axons in Slit-null flies...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193805.
Published: 26 October 2020
.... Loss of CTBP-1 causes multiple defects in SMD axon development: premature outgrowth, defective guidance, delayed termination and absence of retraction. CTBP-1 controls SMD axon guidance by repressing the expression of SAX-7, an L1 cell adhesion molecule (L1CAM). CTBP-1-regulated repression is crucial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev190637.
Published: 07 August 2020
... Caenorhabditis elegans homologue of the H3K4 methyltransferase KMT2F/G (SETD1A/B) genes, controls embryonic transcription of neuronal genes and is required for establishing proper axon guidance, and for neuronal functions related to locomotion and learning. Moreover, we uncover a striking correlation between...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev184523.
Published: 26 June 2020
... fasciculation. Thalamocortical tract Axon guidance Diencephalon Pax6 Thalamus Prethalamic pioneer axons A striking feature of the axonal tracts that interlink the component parts of the nervous system is the high degree of order with which they map the array of neurons in one structure onto...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev176461.
Published: 05 November 2019
... neuron migration is illustrated by the analysis of a human foetus with a KS mutation; in this foetus, GnRH neurons accumulated in neural tangles in the meninges at the level of CP ( Schwanzel-Fukuda et al., 1989 ). Mice lacking the axon guidance cue SEMA3A similarly accumulate GnRH neurons within axon...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev178103.
Published: 09 September 2019
... deduced features in subpopulations of RGCs allowed us to define novel molecular markers that are spatially restricted. Finally, the isolation of such a spatially restricted population, ipsilateral RGCs, allowed us to identify their molecular identity at the time they execute axon guidance decisions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev170704.
Published: 18 February 2019
... stereopsis. Although domain-specific axon guidance cues that discriminate contralateral and ipsilateral RGC axons have long been postulated as a key mechanism for development of the eye-specific retinogeniculate projection, the molecular nature of such cues has remained elusive. Here, we show that the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev172106.
Published: 04 February 2019
...://www.biologists.com/user-licence-1-1/ Highlighted Article: At the ventral midline, developing commissural axons increase Slit sensitivity through a positive-feedback mechanism that is Arf6 mediated and driven by Robo1 receptor endocytic recycling. Slit-Robo Axon guidance Commissural neurons...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev168948.
Published: 16 January 2019
... Perlecan Extracellular matrix ECM Muscle Dorsal median cells Axon guidance Morphogenesis NMJ Proteome analysis of isolated basement membranes (BMs) has identified over 100 associated proteins, highlighting the complex nature of these specialized extracellular matrix (ECM) sheets ( Uechi et...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (21): dev162552.
Published: 02 November 2018
... preganglionic axons to colonise the adrenal primordia. We further identify semaphorin signalling through NRP1 and NRP2 as an important signalling pathway that guides axons and chromaffin cell precursors into this tissue. Although NRP2 is required for preganglionic axonal guidance into the adrenal primordia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (19): dev153692.
Published: 02 October 2018
... in vivo observations indicate that Trio is a master integrator for factors that guide axonal growth and cell migration, and coordinate telencephalic wiring. Trio GEF RhoA Neuron Migration Slit2 Axon guidance Rho GTPase Mouse Embryo Thalamocortical Corridor cells The small...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (18): dev164897.
Published: 21 September 2018
..., EGL-20, through a mechanism that appears to be independent of canonical Fz-type receptors. Our results suggest that RPM-1 and the DLK-1 pathway regulate axon guidance and growth by preventing Wnt signaling crosstalk. * Author for correspondence ( rongo@waksman.rutgers.edu ) Competing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (12): dev159012.
Published: 14 June 2018
... VANGL2 acts non-autonomously from the cochlea to direct turning. Moreover, VANGL2 is asymmetrically distributed at intercellular junctions between cochlear supporting cells, and in a pattern that could allow it to act directly as an axon guidance cue. Together, these data reveal a non-autonomous function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (10): dev151415.
Published: 14 May 2018
... review these axon guidance mechanisms, highlighting the most recent advances in the field that challenge the textbook model of axon guidance. * Author for correspondence ( esther.stoeckli@imls.uzh.ch ) Competing interests The author declares no competing or financial interests. © 2018...
Journal Articles
Journal: Development
Development (2018) 145 (3): dev160093.
Published: 08 February 2018
... shown to cause sciatic nerve and limb abnormalities when overexpressed. Limk1 Axon guidance Clubfoot Limb development Chicken Expression of Limk1 , Eifh4 and Cyln2 was investigated in the PMA mouse by qPCR on cDNA from limbs and neural tubes of E11.5 pma/pma embryos and stage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev151548.
Published: 17 January 2018
.... , Engel , U. , Rusch , J. , Scherrer , S. , Sheard , K. and Van Vactor , D. ( 2004 ). The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance . Neuron   42 , 913 - 926 . 10.1016/j.neuron.2004.05.020...
Journal Articles
Journal: Development
Development (2017) 144 (22): 4078–4090.
Published: 15 November 2017
... of Biologists Ltd 2017 Summary: This Review presents current knowledge of the development of the sensory microdomains in mammalian skin and the mechanosensory neurons that innervate them. Touch Skin Hair follicle Merkel cell Placode Axon guidance Like all senses, the sense...
Journal Articles
Journal: Development
Development (2017) 144 (13): 2504–2516.
Published: 01 July 2017
.... , Tessier-Lavigne , M. and Mason , C. A. ( 2000 ). Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits . J. Neurosci.   20 , 4975 - 4982 . Erskine , L. , Reijntjes , S. , Pratt , T. , Denti , L. , Schwarz , Q...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (5): 856–865.
Published: 01 March 2017
... retardation. However, how PHF8 regulates neurodevelopmental processes and contributes to the disease is still largely unknown. Here, we show that the catalytic activity of a PHF8 homolog in Caenorhabditis elegans , JMJD-1.2, is required non-cell-autonomously for proper axon guidance. Loss of JMJD-1.2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (3): 487–498.
Published: 01 February 2017
... axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor . Cell   101 , 703 - 715 . 10.1016/S0092-8674(00)80883-1 Bateman , J. , Shu , H. and Van Vactor , D. ( 2000 ). The guanine nucleotide exchange factor trio mediates axonal development in...
Includes: Supplementary data