... that the original work is properly attributed. Summary: The short isoform of TOM-1/tomosyn inhibits growth cone protrusion downstream of the netrin receptor UNC-5 during growth cone outgrowth, whereas long isoforms have a pro-protrusive role. Axon guidance Growth cone TOM-1/tomosyn UNC-5 UNC-6...

... topographic sorting errors . Neuron 78 , 49 - 56 . 10.1016/j.neuron.2013.02.005 Poulain , F. E. , Gaynes , J. A. , Stacher Hörndli , C. , Law , M. Y. and Chien , C. B. ( 2010 ). Analyzing retinal axon guidance in zebrafish . Methods Cell Biol. 100 , 3 - 26 . 10.1016...

... innervation. This work establishes the zebrafish vagus nerve as a tractable regeneration model and reveals the mechanistic basis of target-specific regeneration. Axon guidance Axon regeneration Neuron identity Topographic map Vagus Zebrafish National Institutes of Health R01 NS109425 F32...

.... 2 E-E″). The MPS acts as a signaling platform that CB1 and NCAM1 are recruited to upon activation by agonists, leading to the trans-activation of receptor tyrosine kinases and associated downstream signaling ( Zhou et al., 2019 ). As both NCAM1 and CB1 are known to regulate axon guidance...

... 2021 © 2021. Published by The Company of Biologists Ltd 2021 Summary: Members of the HoxD family of transcription factors play an integral role in the synaptic specificity of monosynaptic sensory-motor connections in the developing spinal cord. Axon guidance Motor neuron...

... is sufficient to repel axons. However, longitudinal axon guidance is highly disrupted in tok mutants and can be rescued by midline expression of Slit-N, suggesting that Slit is the primary substrate for Tok in the embryonic CNS. Transgenic restoration of Slit-N or Slit-C does not repel axons in Slit-null flies...

.... Loss of CTBP-1 causes multiple defects in SMD axon development: premature outgrowth, defective guidance, delayed termination and absence of retraction. CTBP-1 controls SMD axon guidance by repressing the expression of SAX-7, an L1 cell adhesion molecule (L1CAM). CTBP-1-regulated repression is crucial...

... , the Caenorhabditis elegans homologue of the H3K4 methyltransferase KMT2F/G (SETD1A/B) genes, controls embryonic transcription of neuronal genes and is required for establishing proper axon guidance, and for neuronal functions related to locomotion and learning. Moreover, we uncover a striking correlation between...

... fasciculation. Thalamocortical tract Axon guidance Diencephalon Pax6 Thalamus Prethalamic pioneer axons A striking feature of the axonal tracts that interlink the component parts of the nervous system is the high degree of order with which they map the array of neurons in one structure onto...

... for neuroendocrine neurons to migrate into the hypothalamus and release gonadotropins into the circulation. GnRH neuron Olfactory bulb Testes Axon guidance Plexin Semaphorin Hypogonadotropic hypogonadism Kallmann syndrome GnRH-secreting neurons are hypothalamic neuroendocrine cells that regulate...

... deduced features in subpopulations of RGCs allowed us to define novel molecular markers that are spatially restricted. Finally, the isolation of such a spatially restricted population, ipsilateral RGCs, allowed us to identify their molecular identity at the time they execute axon guidance decisions...

... stereopsis. Although domain-specific axon guidance cues that discriminate contralateral and ipsilateral RGC axons have long been postulated as a key mechanism for development of the eye-specific retinogeniculate projection, the molecular nature of such cues has remained elusive. Here, we show...

... ipsilateral routes. A similar Arf6-based mechanism might be involved in midline axon guidance in vertebrates. Our analyses showed that, in Arf6 −/− mutants, many commissural axons were able to enter the FP but became stalled at the midline, whereas the other populations of commissural axons presumably...

..., and caused peripheral nervous system defects. Laminin Collagen Perlecan Extracellular matrix ECM Muscle Dorsal median cells Axon guidance Morphogenesis NMJ Proteome analysis of isolated basement membranes (BMs) has identified over 100 associated proteins, highlighting the complex...

... precursors into the adrenal primordia, ensuring correct regulation of the autonomic stress response. Adrenal gland Autonomic nervous system Axon guidance Chromaffin cell Neural crest cell Neuropilin Neuroendocrine chromaffin cells of the adrenal medulla produce adrenaline and noradrenaline...

... and in vivo observations indicate that Trio is a master integrator for factors that guide axonal growth and cell migration, and coordinate telencephalic wiring. Trio GEF RhoA Neuron Migration Slit2 Axon guidance Rho GTPase Mouse Embryo Thalamocortical Corridor cells The small...

..., EGL-20, through a mechanism that appears to be independent of canonical Fz-type receptors. Our results suggest that RPM-1 and the DLK-1 pathway regulate axon guidance and growth by preventing Wnt signaling crosstalk. * Author for correspondence ( rongo@waksman.rutgers.edu ) Competing...

..., and that VANGL2 acts non-autonomously from the cochlea to direct turning. Moreover, VANGL2 is asymmetrically distributed at intercellular junctions between cochlear supporting cells, and in a pattern that could allow it to act directly as an axon guidance cue. Together, these data reveal a non-autonomous function...

... these axon guidance mechanisms, highlighting the most recent advances in the field that challenge the textbook model of axon guidance. Additional short-range axon guidance cues for dI1 navigation at the midline have been identified that affect midline crossing or turning into the longitudinal axis, or both...

... were the best candidates to underlie the motor neuron defects in the PMA mouse on account of known or inferred function in central nervous system (CNS) axon guidance. Limk1 encodes LIM-domain kinase 1, an enzyme that phosphorylates and inactivates the actin-depolymerising protein cofilin ( Yang et al...