... (PNS), the mRNA of Ybx1 is enriched in the axons of dorsal root ganglion (DRG) neurons and can be locally translated. Inhibition of local translation of Ybx1 results in a decrease in axon growth. We further identify 28 target mRNAs of Ybx1 in DRG neurons, including Ttl and Mmp24 . Axon-specific...

... have proven deeply valuable in shaping our understanding of the regulatory players and processes required to terminate axon outgrowth. Axon development Axon growth Axon outgrowth Axon termination Growth cone National Institute of Neurological Disorders and Stroke R01 NS072129...

... intrinsic axon growth capacity or targeting pro-growth tumor suppressor genes such as Pten promotes long-distance axon regeneration in only a small subset of injured retinal ganglion cells (RGCs), despite many RGCs regenerating short-distance axons. A recent study identified αRGCs as the primary type...

...Madhuvanthi Kannan; Shih-Ju Lee; Nicola Schwedhelm-Domeyer; Judith Stegmüller Axon growth is an essential event during brain development and is extremely limited due to extrinsic and intrinsic inhibition in the adult brain. The E3 ubiquitin ligase Cdh1-anaphase promoting complex (APC) has emerged...

... develops postnatally after the onset of root formation( Fristad et al., 1994 ). During development of the peripheral nervous system, growing axons navigate and establish connections to their developing target organs. Regulation of axon growth involves coordinated activity of diffusible and local...

... and axonal growth. Axons of motoneurons transfected with E4BP4 were 3.5-fold longer than control neurons grown on laminin; this effect required the activity of PI3 kinase. In vivo, overexpression of E4BP4 in chicken embryos reduced the number of dying motoneurons by 45%. Our results define E4BP4 as a novel...

... properly. These primary deficits lead to mis-routing of sympathetic nerve trunks and accelerated cell death of sympathetic neurons later in development. Artemin is expressed in blood vessels during periods of early sympathetic differentiation, and can promote and attract axonal growth of the sympathetic...

... of axons in the amphid commissure, a major route of axon entry into the nerve ring. In addition, SAX-3/Robo and the VAB-1/Eph receptor both function to prevent aberrant axon crossing at the ventral midline. Together, these genes define pathways required for axon growth, guidance and maintenance during...

... present in crayfish embryos. We have examined the spatiotemporal pattern of axon growth from a set of early differentiating central neurons in the embryo of two crustaceans, the woodlouse Porcellio scaber and the freshwater crayfish Cherax destructor , and drawn comparisons with insect neurons whose...

... with the basal lamina/extracellular matrix that are non-uniformly distributed along the proximal-distal axis of cockroach legs at the time of pioneer axon growth. Two of these mAbs, PROD-1 and PROD-2, label the proximal parts of the leg more intensely than the distal ends. The other mAb, DIP-1, has the reverse...

... without a morphologically identifiable axon. The antigen 69Al has been purified and shown to be immunochemically closely related or identical to the LI antigen. 09 03 1987 © 1987 by Company of Biologists 1987 neural surface antigen cell adhesion molecule axon growth neurite-neurite...