... on mechanosensory neurons from both invertebrates and vertebrates have proven deeply valuable in shaping our understanding of the regulatory players and processes required to terminate axon outgrowth. Axon development Axon growth Axon outgrowth Axon termination Growth cone National Institute...

... syndrome Autism spectrum disorder RNA-binding proteins Axon development Axon fasciculation Axon targeting The fragile X mental retardation protein (FMRP; encoded by FMR1 ) is an RNA-binding protein that regulates many aspects of gene expression and protein function ( Bagni and Greenough, 2005...

...Takashi Abe; Daisuke Yamazaki; Satoshi Murakami; Makoto Hiroi; Yohei Nitta; Yuko Maeyama; Tetsuya Tabata The Rac-Cofilin pathway is essential for cytoskeletal remodeling to control axonal development. Rac signals through the canonical Rac-Pak-LIMK pathway to suppress Cofilin-dependent axonal growth...

... The authors declare no competing financial interests. 30 1 2013 © 2013. Published by The Company of Biologists Ltd 2013 Axon development Cytoskeleton Motoneurons Mouse embryo Neuromuscular junction Clip3 Cytoplasmic linker proteins, or CLIPs, define a family...

... rearrangement of cytoskeleton in response to extracellular cues is essential. Although previous studies have identified different chemotropic and adhesion molecules that influence axonal development, the molecular mechanism by which these signals control the cytoskeleton remains poorly understood. Here, we show...

... causes abnormal synapse and axon development, and displays striking synergistic interactions with several genes that regulate specific aspects of synapses. SYDN-1 is required in neurons and localizes to distinct regions of the nucleus. Through a genetic suppressor screen, we found that the neuronal...

... , 265 – 280 . 10.1523/JNEUROSCI.08-01-00265.1988 Walter , J. , Henke-Fahle , S. , and Bonhoeffer , F. ( 1987a ). Avoidance of posterior tectal membranes by temporal retinal axons . Development 101 , 909 – 913 . 10.1242/dev.101.4.909 Walter , J. , Kern-Veits...