... Research Council LMCB, Cell Biology Unit, University College of London, Gower Street, London, WC1E 6BT, UK † These authors contributed equally to this work Competing interests statement 18 12 2009 © 2010. Axis determination Cell polarity Drosophila Oogenesis...

...-mail: [email protected] ) 03 03 2001 19 04 2001 © 2001 by Company of Biologists 2001 Hedgehog Hematopoiesis Vasculogenesis Gastrulation Axis determination Mouse embryo Morphogenesis and patterning of the vertebrate embryo are dependent upon finely orchestrated interactions...

... formation. * Author for correspondence at address 1 (e-mail: [email protected] ) 18 05 1999 10 07 2000 © 2000 by Company of Biologists 2000 E2F Drosophila Oogenesis Gurken Cell cycle Axis determination Control of the cell cycle is essential...

... reported that Smad2 mutant embryos develop normal yolk sacs in the absence of any embryonic tissues ( Waldrip et al., 1998 ). The Smad2 pathway thus plays a critical role in A-P axis determination, evidently by restricting the site of primitive streak formation. TGF β signals transmitted through Smad2...

... position of the equator is unknown because the factor of the cytoplasmic core that interacts with the dorsal determinant is unknown. Black and Gerhart (1986) centrifuged fertilized uncleaved eggs twice in opposite directions and showed that the grey crescent was not an exclusive axis determinant...

... that would otherwise occur by default. 01 08 1994 © 1994 by Company of Biologists 1994 ascidian embryogenesis axis determination cytoplasmic determinants cleavage pattern cytoplasmic transfer In the unfertilized eggs of many kinds of animal, there is a single axis, namely...

...-independent immediate-early genes. * Author for correspondence 21 01 1994 © 1994 by Company of Biologists 1994 mesoderm induction cytoplasmic determinants gene expression Xwnt-8 goosecoid Xbra Xenopus axis determination in situ hybridisation In early...

... structural genes operate. 22 12 1989 © 1990 by Company of Biologists 1990 variable cleavage invariant cleavage axis determination cell fate conditional specification autonomous specification gene regulation regulative development cytoplasmic localization cell–cell interaction...

... its transplantation. 17 05 1988 © 1988 by Company of Biologists 1988 somite cartilage rostrocaudal axis chick-quail chimera dermomyotome sclerotome axis determination In the course of the normal development of multicellular organisms, individual cells have...