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Keywords: Axin2
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Journal Articles
Journal: Development
Development (2018) 145 (4): dev158048.
Published: 21 February 2018
... perturbing epithelial Wnt/β-catenin signaling. In addition, loss-of-function mutations in the Wnt feedback inhibitor AXIN2 lead to human tooth agenesis. We have investigated the functions of Wnt/β-catenin signaling during sequential formation of molar teeth using mouse models. Continuous initiation of new...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (17): 3128–3142.
Published: 1 September 2016
.... Here, we studied activation of Wnt/β-catenin signaling in adult muscle fibers and muscle stem cells in an Axin2 reporter mouse. Axin2 is a negative regulator and a target of Wnt/β-catenin signaling. In adult muscle fibers, Wnt/β-catenin signaling is only detectable in a subset of fast fibers that have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (6): 1041–1054.
Published: 15 March 2016
... through its earlier activity in neighboring myocardial cells or their progenitors. Subsequently, Wnt/β-catenin signaling is activated in cushion mesenchymal cells where it supports FGF-driven expansion of ECs and then AVC valve extracellular matrix patterning. Mice lacking Axin2 , a negative Wnt regulator...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (8): 1995–2005.
Published: 15 April 2005
...Hsiao-Man Ivy Yu; Boris Jerchow; Tzong-Jen Sheu; Bo Liu; Frank Costantini; J. Edward Puzas; Walter Birchmeier; Wei Hsu Axin1 and its homolog Axin2/conductin/Axil are negative regulators of the canonical Wnt pathway that suppress signal transduction by promoting degradation of β-catenin. Mice...