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Keywords: Axin
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Journal Articles
Journal: Development
Development (2021) 148 (7): dev191197.
Published: 31 March 2021
... embryos for normal AP patterning is less well understood. To investigate this process in an invertebrate deuterostome, we defined Axin function in early sea urchin embryos. Axin is ubiquitously expressed at relatively high levels in early embryos and functional analysis revealed that Axin suppresses...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev164145.
Published: 02 July 2019
...Daniel B. Lybrand; Misha Naiman; Jessie May Laumann; Mitzi Boardman; Samuel Petshow; Kevin Hansen; Gregory Scott; Marcel Wehrli ABSTRACT The central regulator of the Wnt/β-catenin pathway is the Axin/APC/GSK3β destruction complex (DC), which, under unstimulated conditions, targets cytoplasmic β...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (6): dev169284.
Published: 15 March 2019
...Yetis Gultekin; Hermann Steller ABSTRACT Self-renewal of intestinal stem cells is controlled by Wingless/Wnt-β catenin signaling in both Drosophila and mammals. As Axin is a rate-limiting factor in Wingless signaling, its regulation is essential. Iduna is an evolutionarily conserved ubiquitin E3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1710–1720.
Published: 15 May 2016
...) have become lead therapeutic candidates for Wnt-driven cancers, following the recent discovery that Tnks targets Axin, a negative regulator of Wnt signaling, for proteolysis. Initial reports indicated that Tnks is important for Wnt pathway activation in cultured human cell lines. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4226–4236.
Published: 15 October 2013
... test several hypotheses related to the mechanism of action of APC2, revealing that APC2 functions at the embryonic cortex with several protein partners, including Axin, to promote mitotic fidelity. Our in vivo data demonstrate that APC2 protects genome stability by modulating mitotic fidelity through...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1501–1506.
Published: 15 April 2011
... a threshold for the amount of this form of Armadillo and therefore for Wnt signalling. In the current model of Wnt signalling, a complex assembled around Axin and Apc allows GSK3 (Shaggy) to phosphorylate Armadillo and target it for degradation. However, genetic experiments suggest that the loss of function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (2): 367–375.
Published: 15 January 2008
...) initiates Wnt/β-catenin signaling. Here we show that both Fz and Dvl functions are critical for Wnt-induced Lrp6 phosphorylation through Fz-Lrp6 interaction. We also show that axin, a key scaffolding protein in the Wnt pathway, is required for Lrp6 phosphorylation via its ability to recruit Gsk3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (16): 3191–3200.
Published: 15 August 2006
... that promotes forebrain development and inhibits Wnt signaling by activating the transcription of secreted Wnt antagonists. * Author for correspondence (e-mail: monte@uoneuro.uoregon.edu ) 12 6 2006 © 2006. 2006 Axin Forebrain Lhx5 LIM-homeobox domain factor masterblind Secreted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (8): 1995–2005.
Published: 15 April 2005
... ). Functional interaction of an axin homolog, conductin,with beta-catenin, APC, and GSK3beta. Science 280 , 596 -599. Brannon, M., Gomperts, M., Sumoy, L., Moon, R. T. and Kimelman,D. ( 1997 ). A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus...
Journal Articles
Journal: Development
Development (2004) 131 (23): 5923–5933.
Published: 01 December 2004
... for subdivision of midline neural tissue into hypothalamic and floorplate domains are uncertain, and in this study, we have explored the role of the Wnt/Axin/β-catenin pathway in this process. This pathway has been implicated in anteroposterior regionalisation of the dorsal neural tube but its role in patterning...
Journal Articles
Journal: Development
Development (2002) 129 (23): 5313–5322.
Published: 01 December 2002
... of the eye-antennal imaginal disc, we induced clones either mutant for the negative regulator of Wingless signalling, Axin,or expressing an activated form of Armadillo (Arm * )( Brunner et al., 1997 ). Axin is a scaffold protein necessary for the phosphorylation of Armadillo/β-catenin by the glycogen...