... in a head-to-tail (anterior-posterior) direction and it is driven by developmentally plastic axial progenitors, which can generate both spinal cord neurectoderm and presomitic/paraxial mesoderm, the precursor of the vertebral column/trunk musculature [thus termed neuromesodermal progenitors (NMPs); reviewed...

... that Epha1 expression is restricted to the axial progenitor-containing areas of the mouse embryo. Epha1-positive cells isolated from the mouse tailbud generate neural and mesodermal derivatives when cultured in vitro . This observation, together with their enrichment in the Sox2 + /Tbxt + molecular phenotype...

...Aida Rodrigo Albors; Pamela A. Halley; Kate G. Storey ABSTRACT The vertebrate body forms by continuous generation of new tissue from progenitors at the posterior end of the embryo. The study of these axial progenitors has proved to be challenging in vivo largely because of the lack of unique...