... development, as well as in morphogenetic movements of gastrulation and axial elongation. Our findings suggest that the mesoderm-inducing role of FGF extends beyond the group of deuterostomes. Embryos were permeabilized in 100% methanol for 1 h, digested with Proteinase K (10 µg ml −1 ; Sigma-Aldrich...

... of neuromesodermal progenitors in zebrafish through a combination of genetic clonal labelling, forward fate mapping and in toto imaging. Zebrafish Gastrulation Tailbud Axial elongation In amniotes, a bipotent population of posterior progenitors continually allocate cells to the posterior pre...

.... Neuromesoderm progenitors Tbx6 Axial elongation Trunk-tail transition Mouse The discovery of neuromesoderm progenitors (NMPs) has fundamentally impacted our understanding of the development of vertebrate body plan ( Henrique et al., 2015 ; Stern et al., 2006 ; Steventon and Martinez Arias, 2017...

... and cell behaviour, as well as axis elongation. The responses are signal specific and uncouple processes that in the embryo are tightly associated, such as specification of the anteroposterior axis and anterior neural development, or endoderm specification and axial elongation. We discuss the meaning...

... a microarray screen to identify RAR targets, we identified a subset of genes that pattern caudal structures or promote axial elongation and are upregulated by increased RAR-mediated repression. Previous studies have suggested that RAR is present in the caudal domain, but is quiescent until its activation...

... streak, the subsequent polarized protrusive activity, and CE and axial elongation all failed. The mesoderm normally thickens and extends, but on failure of convergence movements in Ptk7 mutants, the mesoderm underwent radial intercalation and excessive thinning,which suggests that a cryptic radial cell...

... Axial elongation Mechanics Young's modulus Viscoelasticity Biomechanics Extracellular matrix Microfilaments Xenopus Dorsal elongation and neural tube closure during early development are inherently mechanical events, yet little is known about the mechanical principles that drive...

...Noemí Cambray; Valerie Wilson In mammals, the primitive streak region and its descendant, the tail bud,are the source of nascent mesoderm and spinal cord throughout axial elongation. A localised population of long-term axial progenitors has been identified in a region of the tail bud...

... ( Takada et al., 1994 ) and Fgfr1 ( Partanen et al., 1998 ) hypomorph mutants. This suggests that these transcription factors and signalling molecules all participate in posterior axial elongation, either by facilitating convergence/extension movements (reviewed by Sokol, 2000 ), or by maintaining...

... reported in our study of tail bud development (Catala, M., Teillet, M.-A. and Le Douarin, N.M. (1995). Mech. Dev . 51, 51-65), these results show that the mechanisms that preside at axial elongation from the 6-somite stage onwards are fundamentally similar during the complete process of neurulation...