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Keywords: Autoregulation
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Journal Articles
Journal: Development
Development (2020) 147 (18): dev193482.
Published: 28 September 2020
.../Notch activity, indicating that lag-1 engages in direct positive autoregulation. Deletion of the HOT region from endogenous lag-1 reduced LAG-1 levels and abrogated positive autoregulation, but did not cause hallmark cell fate transformations associated with loss of lin-12 / Notch or lag-1 activity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev177378.
Published: 21 June 2019
... that such autoregulation serves to maintain the differentiated state of a cell. To experimentally test this assumption, we used CRISPR/Cas9-mediated genome engineering to delete a transcriptional autoregulatory, cis -acting motif in the che-1 zinc-finger transcription factor locus, a terminal selector...
Journal Articles
Journal: Development
Development (2008) 135 (19): 3219–3228.
Published: 01 October 2008
... with the establishment of Pc silencing. The en gene, like Ubx , is negatively autoregulated in imaginal discs ( Guillén et al.,1995 ; Simmonds et al.,1995 ; Tabata et al.,1995 ) and is also regulated by Pc -group proteins( Busturia and Morata, 1988 ; Moazed and O'Farrel, 1992 ; McKeon et...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (3): 545–555.
Published: 01 February 2007
... Pax6 in a normal spatial pattern, with levels up to three times higher than wild type. By crossing PAX77 mice with a new YAC transgenic line that reports Pax6 expression (DTy54), we showed that increased expression is limited by negative autoregulation. Increased expression reduces proliferation of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (1): 111–121.
Published: 01 January 2003
... ganglia of Brn3a +/+ and Brn3a +/- mice are similar, demonstrating that autoregulation can compensate for the loss of one allele by increasing transcription of the remaining gene copy. Conversely, transgenic overexpression of Brn3a in the trigeminal ganglion suppresses the expression of the endogenous...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4535–4545.
Published: 01 October 2002
...., Philpott, A., Bang, A. and Harris, W. A. ( 1999 ). Giant eyes in Xenopus laevis by overexpression of XOptx2. Cell 98 , 341 -352. §Author for correspondence (e-mail: pgruss@gwdg.de ) 26 6 2002 © 2002. 2002 Pax6 Enhancer Retina Autoregulation Axon guidance Superior...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3715–3725.
Published: 01 August 2002
... when Cctra autoregulation is prevented and instead splice variants with truncated open reading frames are produced. We propose that this repression is achieved by the Y-linked male-determining factor ( M ). *Author for correspondence (e-mail: saccone@biol.dgbm.unina.it ) 30 4 2002...
Journal Articles
Journal: Development
Development (2001) 128 (23): 4705–4714.
Published: 01 December 2001
...-specific allele, da lyh , we show that da expression is not constitutive, but is dynamically regulated. This transcriptional regulation includes somatic ovary-specific activation, autoregulation and negative regulation. Unexpectedly, the diverse functions of da may require that expression levels be tightly...
Journal Articles
Journal: Development
Development (2001) 128 (19): 3717–3728.
Published: 01 October 2001
... embryo. Ascidian T-box gene As-T2 Function Minimal promoter T protein-binding motif Autoregulation Muscle-specific gene expression The T-box genes encode a family of transcription factors that share an evolutionarily conserved T DNA-binding domain first defined in the product of the...
Journal Articles
Journal: Development
Development (2001) 128 (12): 2341–2350.
Published: 15 June 2001
... provide the first in vivo evidence that gata1 gene expression undergoes positive autoregulation. To analyze the regulatory mechanism that controls zebrafish gata1 transcription, genomic DNA fragments containing the gata1 gene were cloned and characterized. Using cDNA corresponding to the open...