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Keywords: Aurora A
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Reproductive biology
Journal: Development
Development (2024) 151 (7): dev202479.
Published: 10 April 2024
... is governed by evolutionarily conserved Partitioning-defective (PAR) proteins that segregate to opposing cortical domains to specify asymmetric cell fates. Timely establishment of PAR domains requires a cell cycle kinase, Aurora A (AIR-1 in C. elegans ). Aurora A depletion by RNAi causes a spectrum...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev174565.
Published: 21 November 2019
... of the cortical actomyosin network, and breaks symmetry to direct partitioning of the PAR proteins. However, the molecular nature of the centrosomal signal that triggers cortical anisotropy in the actomyosin network to promote polarity establishment remains elusive. Here, we discover that depletion of Aurora...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (19): 3315–3325.
Published: 1 October 2010
... cycle progression in C. elegans embryos. We find that, similarly to mammalian cells, SPAT-1 acts with PLK-1 and not with the mitotic kinase Aurora A (AIR-1), as shown in Drosophila . SPAT-1 binds to PLK-1, and depletion of SPAT-1 or PLK-1 leads to similar cell division defects in early embryos, which...
Includes: Multimedia, Supplementary data