... suggest that the Ft-Ds pathway regulates PCP propagation independently of asymmetric cellular accumulation of Ft or Ds. We find that the Ft effector Atrophin has a position-specific role in regulating polarity in the eye, and that asymmetric accumulation of the atypical myosin Dachs is not essential...

..., the transcriptional co-repressor Atrophin (Atro) physically interacts with Ft and acts as a component of Fat signaling for planar polarity. We find that the mammalian orthologs of atro, Atn1 and Atn2l , modulate Fat4 activity during vertebral arch fusion and renal tubular elongation, respectively. Moreover, Fat4...

... mutation also produces PCP defects that extend distal to the PCV ( Fig. 7B ). * Author for correspondence (e-mail: [email protected] ) 27 3 2006 © 2006. 2006 Overgrowth Junction Four-jointed Dachs Frizzled Grunge Atrophin The Drosophila proteins Fat...

...J. Susie Zoltewicz; Nicola J. Stewart; Ricky Leung; Andrew S. Peterson Atrophins are evolutionarily conserved proteins that are thought to act as transcriptional co-repressors. Mammalian genomes contain two atrophin genes. Dominant polyglutamine-expanded alleles of atrophin 1 have been identified...

..., CA 94720-3140, USA 4 8 2003 © 2003. 2003 Axon guidance Homeodomain Transcriptional repressor Evx Hb9 Grunge Atrophin Groucho Eve Nervous system The homeobox-containing gene even skipped ( eve ) was first identified as a segmentation gene based on the cuticular...

...Manolis Fanto; Lesley Clayton; Jamie Meredith; Kirsten Hardiman; Bernard Charroux; Stephen Kerridge; Helen McNeill Fat is an atypical cadherin that controls both cell growth and planar polarity. Atrophin is a nuclear co-repressor that is also essential for planar polarity; however, it is not known...