... spatiotemporal inhibition of Wnt/β-catenin signaling by chemically inducible overexpression of Dkk1. Unexpectedly, this approach indicates canonical Wnt signaling is required for EMT in the proximal outflow tract (pOFT) but not atrioventricular canal (AVC) cushions. Furthermore, Wnt indirectly promotes pOFT EMT...

... R. M. , De Val S. , Kang G. , Jan L. Y. , Black B. L. , Stainier D. Y. ( 2008 ). Foxn4 directly regulates tbx2b expression and atrioventricular canal formation . Genes Dev. 22 , 734 - 739 . D’Amico L. , Scott I. C. , Jungblut B. , Stainier D...

...Kelly A. Smith; Anne K. Lagendijk; Andrew D. Courtney; Huijun Chen; Scott Paterson; Benjamin M. Hogan; Carol Wicking; Jeroen Bakkers The atrioventricular canal (AVC) physically separates the atrial and ventricular chambers of the heart and plays a crucial role in the development of the valves...

... to create concentric layers of the heart tube, and communicate during formation of the atrioventricular canal. Here, we identify a novel transmembrane protein, Tmem2, that has important functions during both myocardial and endocardial morphogenesis. We find that the zebrafish mutation frozen ventricle ( frv...

...Joshua B. Rutenberg; Andreas Fischer; Haibo Jia; Manfred Gessler; Tao P. Zhong; Mark Mercola Mutations in Notch2, Jagged1 or homologs of the Hairy-related transcriptional repressor Hey2 cause congenital malformations involving the non-chamber atrioventricular canal (AVC) and inner curvature (IC...

... is expressed in the outflow tract, inner curvature, atrioventricular canal and inflow tract, corresponding to a myocardial zone that is excluded from chamber differentiation at 9.5 days post coitus (dpc). We have used targeted mutagenesis in mice to investigate Tbx2 function. Mice heterozygous for a Tbx2 null...