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Keywords: Ataxia
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Journal Articles

Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death

Joseph H. McCarty, Adam Lacy-Hulbert, Alain Charest, Roderick T. Bronson, Denise Crowley, David Housman, John Savill, Jürgen Roes, Richard O. Hynes
Journal: Development
Development (2005) 132 (1): 165–176.
https://doi.org/10.1242/dev.01551
Published: 1 January 2005
...% of these mutants develop seizures and die by 4 weeks of age. The remaining mutants survive for several months, but develop axonal deterioration in the spinal cord and cerebellum,leading to ataxia and loss of hindlimb coordination. Collectively, these data provide evidence that αv integrins on embryonic central...
View article titled, Selective ablation of αv integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
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