..., we provide developmental and transcriptomic evidence that the differentiation of lepidopteran scales derives from the sensory organ precursor (SOP). Live imaging in lepidopteran pupae shows that SOP cells undergo two asymmetric divisions that first abrogate the neurogenic lineage, and then lead...

... EFL-3/E2F7 Asymmetric division Seam cell Wnt signalling LIT-1/NLK Wellcome Trust http://dx.doi.org/10.13039/100010269 219448/Z/19/Z ‘la Caixa’ Foundation Imperial College London http://dx.doi.org/10.13039/501100000761 Development of multicellular...

...). This asymmetric division requires a modified centrosome cycle, wherein mitotic centrosomes with mature pericentriolar material (PCM) embed in the NL and interphase centrosomes with reduced PCM leave the NL. This centrosome cycle requires Emerin, an NL protein required for GSC survival and germ cell...

...Adrian Candelas; Benoit Vianay; Matthieu Gelin; Lionel Faivre; Jerome Larghero; Laurent Blanchoin; Manuel Théry; Stéphane Brunet ABSTRACT Hematopoietic stem and progenitor cells (HSPCs) give rise to all cell types of the hematopoietic system through various processes, including asymmetric divisions...

... , A. and Borgonie , G. ( 2008 ). The embryonic cell lineage of the nematode Rhabditophanes sp . Int. J. Dev. Biol. 52 , 963 - 967 . 10.1387/ijdb.072404wh Jankele , R. , Jelier , R. and Gönczy , P. ( 2021 ). Physically asymmetric division of the C. elegans zygote ensures...

... asymmetric division of Drosophila sensory organ precursor cells . Elife 10 , e66659 . 10.7554/eLife.66659 Izumi , Y. and Furuse , M. ( 2014 ). Molecular organization and function of invertebrate occluding junctions . Semin. Cell Dev. Biol. 36 , 186 - 193 . 10.1016/j.semcdb...

.... Ankle2 Drosophila Asymmetric division Microcephaly Model of human disease Every in vivo approach used to study genetic variants associated with human disease has benefits and caveats. Whether the system is based on human cells in culture, primates, rodents, fish, flies, worms or yeast...

...Shilpa Kaur; Pauline Mélénec; Sabrina Murgan; Guillaume Bordet; Pierre Recouvreux; Pierre-François Lenne; Vincent Bertrand ABSTRACT Wnt/β-catenin signalling has been implicated in the terminal asymmetric divisions of neuronal progenitors in vertebrates and invertebrates. However, the role of Wnt...

... regulatory program. Lineage size Cell cycle Asymmetric division Combinatorial control Nervous system development Evolution of the CNS Vetenskapsrådet 621-2013-5258 Knut och Alice Wallenbergs Stiftelse 10.13039/501100004063 KAW2011.0165 KAW2012.0101 Cancerfonden...

... diversity in multicellular organisms. Several conventional genetics studies have attempted to elucidate the mechanisms underlying cell polarization in plants, but it remains largely unknown. In plants, stomata, which are valves for gas exchange, are generated through several rounds of asymmetric divisions...

... © 2016. Published by The Company of Biologists Ltd 2016 Summary: During Drosophila embryonic CNS development, the zinc-finger protein Sequoia interacts with the Notch pathway to control lineage progression. Lineage tree Cell cycle Asymmetric division Combinatorial control Notch...

... similarities between plant and animal developmental mechanisms. Asymmetric division bHLH proteins Epigenetic regulation of differentiation Lineage-specific stem cells Peptide signaling Stomata Stomata are small cellular valves found on the epidermis of land plants that facilitate gas...

... re-enter the cell cycle to proliferate and subsequently exit the cell cycle to differentiate or self-renew. Recent studies have demonstrated that satellite cells are heterogeneous and that subpopulations of satellite stem cells are able to perform asymmetric divisions to generate myogenic progenitors...

... that the original work is properly attributed. Neural stem cells Neural progenitor cells Multipotency Asymmetric division Retina Medaka Embryonic progenitor and stem cells generate new differentiated cells during the initial phases of development. Post-embryonic stem cells deal with a rather...

...Shihadeh Anani; Shivani Bhat; Nobuko Honma-Yamanaka; Dayana Krawchuk; Yojiro Yamanaka In the mouse embryo, asymmetric divisions during the 8-16 cell division generate two cell types, polar and apolar cells, that are allocated to outer and inner positions, respectively. This outer/inner...

... the asymmetric division, showing the commitment of the future daughter cell to differentiation. The coordination of these two alternative cell cycles contributes to the continuous production of infective parasites, turning the tsetse fly into an efficient and long-lasting vector for African trypanosomes...

...Marjolein Wildwater; Nicholas Sander; Geert de Vreede; Sander van den Heuvel Tissue-specific stem cells combine proliferative and asymmetric divisions to balance self-renewal with differentiation. Tight regulation of the orientation and plane of cell division is crucial in this process. Here, we...

... 2011. 2011 F-actin Asymmetric division Meiosis Mouse Oocyte Asymmetric cell division requires correct spindle positioning with regards to the polarity axis of the mother cell ( Gonczy, 2008 ). In most models, mitotic spindle positioning depends on pulling forces produced by astral...

..., we report that CySCs divide asymmetrically through repositioning the mitotic spindle around anaphase. CySC spindle repositioning requires functional centrosomes, Dynein and the actin-membrane linker Moesin. Anaphase spindle repositioning is required to achieve high-fidelity asymmetric divisions...

... of first appearance of mosaic expression of EPI and PE markers at the E3.5 blastocyst stage. Our data showed that most eight-cell blastomeres generate either primary or secondary inner cells but rarely both. It is very rare for a polar cell derived from an asymmetric division of an eight-cell...