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Keywords: Asymmetric cell division
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Journal Articles
Journal: Development
Development (2022) 149 (4): dev200275.
Published: 18 February 2022
... neuroblasts and low to no active Notch is required for neuroblast reactivation in response to dietary nutrients. Notch signaling Neural stem cell Quiescence Neuroblast Delta Tribbles Hippo PI3-kinase Dacapo Asymmetric cell division Cell cycle Drosophila National Institutes...
Includes: Supplementary data
Journal Articles
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Plant development
Journal: Development
Development (2021) 148 (18): dev199919.
Published: 27 September 2021
...Yan Gong; Julien Alassimone; Andrew Muroyama; Gabriel Amador; Rachel Varnau; Ao Liu; Dominique C. Bergmann ABSTRACT In many land plants, asymmetric cell divisions (ACDs) create and pattern differentiated cell types on the leaf surface. In the Arabidopsis stomatal lineage, BREAKING OF ASYMMETRY...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev191437.
Published: 10 January 2021
... activation relies on the correct localization of the Notch signalling actors. We report that AP-1 and Stratum ensure the basolateral targeting of Notch during asymmetric cell division. Notch signalling Intracellular trafficking Asymmetric cell division Stratum AP-1 Cell-cell signalling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (13): dev167650.
Published: 29 June 2020
...Bharath Sunchu; Clemens Cabernard ABSTRACT Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed mechanistic understanding of ACD is therefore necessary to understand cell fate...
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180034.
Published: 18 November 2019
...Suzanne E. M. van der Horst; Janine Cravo; Alison Woollard; Juliane Teapal; Sander van den Heuvel ABSTRACT A correct balance between proliferative and asymmetric cell divisions underlies normal development, stem cell maintenance and tissue homeostasis. What determines whether cells undergo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev170589.
Published: 29 January 2019
... with high specificity and temporal control. Drosophila Asymmetric cell division atypical Protein Kinase C Chemical genetics Neuroblasts The polarization of the cell cortex is a key mechanism for proper epithelial cell organization as well as for the production of different cell types...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (21): dev170613.
Published: 6 November 2018
... Asymmetric cell division Centrosome Growth factors Primary microcephaly During embryonic development in higher vertebrates, the brain and anterior spinal cord are formed through primary neurulation of the embryonic neural plate, which produces a hollow neural tube (NT) that acts as the primordium...
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (14): dev165860.
Published: 17 July 2018
... of the MAPK kinase kinase gene BdYODA1 in regulating asymmetric cell divisions. We find that YODA genes promote normal stomatal spacing patterns in both Arabidopsis and Brachypodium , despite species-specific differences in those patterns. Using lineage tracing and cell fate markers, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev163469.
Published: 2 July 2018
... nucleotide exchange factor for Rab GTPases, is involved in restricting the apical delivery of Sanpodo to control spatiotemporal Notch activation following asymmetric cell division in Drosophila sensory organs. Asymmetric cell division Notch signaling Rab8 Stratum Guanine nucleotide exchange...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev164988.
Published: 30 May 2018
.... C. elegans embryo Phosphoinositides PIP 2 Asymmetric cell division Actin PAR polarity Asymmetric division generates cellular diversity and is prevalent throughout development. During intrinsic asymmetric division, cell polarity is first established and then coupled with spindle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (9): 1607–1618.
Published: 1 May 2017
... establishes cell polarity in the gonadal coelomic epithelium and is required for asymmetric cell division and somatic cell fate specification during gonadogenesis. NUMB NOTCH Mouse gonad Cell polarity Asymmetric cell division Coelomic epithelium The undifferentiated gonadal primordia arise...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1137–1145.
Published: 1 April 2017
..., then, is interphase cell shape translated through mitosis? The spindle-orienting machinery, or at least part of it, provides the answer. Spindle orientation plays a crucial role in animal development. In particular, its importance for asymmetric cell division (ACD) has long been recognized. The term ACD...
Journal Articles
Journal: Development
Development (2016) 143 (4): 575–581.
Published: 15 February 2016
... by The Company of Biologists Ltd 2016 Highlighted article: LGN inactivation in mice disrupts spindle orientation in both the retina and neocortex but leads to very different outcomes with regards to cell fate in each context. Asymmetric cell division Retina Cell lineage Oriented divisions Cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (4): 670–681.
Published: 15 February 2016
... suprabasal tissue by asymmetric cell division, while Shh triggers cell rearrangement in this tissue to drive invagination all the way to bud formation. * Author for correspondence ( jeremy.green@kcl.ac.uk ) Competing interests The authors declare no competing or financial interests. 24 8...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (1): 35–44.
Published: 1 January 2016
... asymmetric cell division . Curr. Biol.   19 , 723 - 729 . 10.1016/j.cub.2009.03.056 Azam , S. , Drobetsky , E. and Ramotar , D. ( 2007 ). Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis . Apoptosis   12 , 1243 - 1255 . 10.1007/s10495-006-0050...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 832–839.
Published: 1 March 2015
... also being required for the proper distribution of F-actin and Par3 at the daughter cell apical domain. Our time-lapse analysis of asymmetric cell divisions of RGC progenitors suggests that the differentiating (RGC) daughter transiently inherits the Anillin-eGFP-labelled midbody. This is in agreement...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 420–430.
Published: 1 February 2015
.... , Pysh , L. , Helariutta , Y. , Freshour , G. , Hahn , M. G. , Feldmann , K. A. and Benfey , P. N. ( 1996 ). The SCARECROW gene regulates an asymmetric cell division that is essential for generating the radial organization of the Arabidopsis root . Cell   86 , 423 - 433...
Journal Articles
Journal: Development
Development (2015) 142 (3): 444–453.
Published: 1 February 2015
..., such as enhanced root growth, increased number of cortex/endodermis stem cells and decreased number of columella layers. Our phenotypic and gene expression analyses indicated that PUB4 promotes expression of a cell cycle regulatory gene, CYCD6;1 , and regulates formative periclinal asymmetric cell divisions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (1): 62–69.
Published: 1 January 2015
...Zsolt G. Venkei; Yukiko M. Yamashita Asymmetric cell division is utilized by a broad range of cell types to generate two daughter cells with distinct cell fates. In stem cell populations asymmetric cell division is believed to be crucial for maintaining tissue homeostasis, failure of which can lead...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (13): 2724–2734.
Published: 1 July 2014
... observed that TOE-2ΔDEP localized normally, suggesting a different role for the DEP domain of TOE-2. It is likely that the DEP domain mediates the interaction between TOE-2 and other proteins that regulate asymmetric cell division in the neuroblasts of the Q lineage. The DEP domain of Sst2, an RGS...
Includes: Supplementary data