... to no active Notch is required for neuroblast reactivation in response to dietary nutrients. Notch signaling Neural stem cell Quiescence Neuroblast Delta Tribbles Hippo PI3-kinase Dacapo Asymmetric cell division Cell cycle Drosophila National Institutes of Health http://dx.doi.org...

...Yan Gong; Julien Alassimone; Andrew Muroyama; Gabriel Amador; Rachel Varnau; Ao Liu; Dominique C. Bergmann ABSTRACT In many land plants, asymmetric cell divisions (ACDs) create and pattern differentiated cell types on the leaf surface. In the Arabidopsis stomatal lineage, BREAKING OF ASYMMETRY...

... activation relies on the correct localization of the Notch signalling actors. We report that AP-1 and Stratum ensure the basolateral targeting of Notch during asymmetric cell division. Notch signalling Intracellular trafficking Asymmetric cell division Stratum AP-1 We have previously...

...Bharath Sunchu; Clemens Cabernard ABSTRACT Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed mechanistic understanding of ACD is therefore necessary to understand cell fate...

...Suzanne E. M. van der Horst; Janine Cravo; Alison Woollard; Juliane Teapal; Sander van den Heuvel ABSTRACT A correct balance between proliferative and asymmetric cell divisions underlies normal development, stem cell maintenance and tissue homeostasis. What determines whether cells undergo...

... Atwood , S. X. and Prehoda , K. E. ( 2009 ). aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division . Curr. Biol.   19 , 723 - 729 . 10.1016/j.cub.2009.03.056 Bailey , M. J. and Prehoda , K. E. ( 2015 ). Establishment of Par...

... Asymmetric cell division Centrosome Growth factors Primary microcephaly During embryonic development in higher vertebrates, the brain and anterior spinal cord are formed through primary neurulation of the embryonic neural plate, which produces a hollow neural tube (NT) that acts as the primordium...

... of the MAPK kinase kinase gene BdYODA1 in regulating asymmetric cell divisions. We find that YODA genes promote normal stomatal spacing patterns in both Arabidopsis and Brachypodium , despite species-specific differences in those patterns. Using lineage tracing and cell fate markers, we show...

... ). Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division . Nature   458 , 1051 - 1055 . 10.1038/nature07854 Court , H. , Ahearn , I. M. , Amoyel , M. , Bach , E. A. and Philips , M. R. ( 2017 ). Regulation of NOTCH signaling by RAB7 and RAB8...

.... , Kusch , M. and Kemphues , K. ( 1990 ). Mutations in the par genes of Caenorhabditis elegans affect cytoplasmic reorganization during the first cell cycle . Dev. Biol.   142 , 203 - 215 . 10.1016/0012-1606(90)90164-E Knoblich , J. A. ( 2010 ). Asymmetric cell division: recent...

... establishes cell polarity in the gonadal coelomic epithelium and is required for asymmetric cell division and somatic cell fate specification during gonadogenesis. NUMB NOTCH Mouse gonad Cell polarity Asymmetric cell division Coelomic epithelium The undifferentiated gonadal primordia arise...

... is regulated and localized to allow correct mitotic spindle orientation. Asymmetric cell division Mitotic spindle Spindle orientation Wellcome Trust 10.13039/100004440 Spindle orientation plays a crucial role in animal development. In particular, its importance for asymmetric cell...

... independent experiments, presented as means±s.e.m., two-tailed t-test). Fig. 4. LGN and Gαi activity are required for terminal asymmetric cell divisions in the retina. (A) Examples of two-cell clones obtained 14 days after infection of Lgn +/− or Lgn −/− retinal explants at P0 with a GFP...

... suprabasal tissue by asymmetric cell division, while Shh triggers cell rearrangement in this tissue to drive invagination all the way to bud formation. References Ahtiainen , L. , Lefebvre , S. , Lindfors , P. H. , Renvoisé , E. , Shirokova , V. , Vartiainen , M. K. , Thesleff...

... Summary: Basal localisation of Miranda, essential for asymmetric neuroblast division in Drosophila , is regulated during mitosis via a two-step process involving PTPA/PP4 and aPKC. Drosophila neuroblast Asymmetric cell division PTPA Dephosphorylation of Mira The asymmetric division...

... to the regulation of asymmetric neurogenic cell divisions in the retinal neuroepithelium – favouring the maintenance of proliferating progenitors while also being required for the proper distribution of F-actin and Par3 at the daughter cell apical domain. Our time-lapse analysis of asymmetric cell divisions of RGC...

.... Arabidopsis Embryogenesis Pattern formation Cell specification Asymmetric cell division Cell-cell communication Auxin Plants can grow for many centuries and new organs, such as leaves, branches, flowers and roots, are continuously added to build elaborate and complex post-embryonic structures...

..., such as enhanced root growth, increased number of cortex/endodermis stem cells and decreased number of columella layers. Our phenotypic and gene expression analyses indicated that PUB4 promotes expression of a cell cycle regulatory gene, CYCD6;1 , and regulates formative periclinal asymmetric cell divisions...

...Zsolt G. Venkei; Yukiko M. Yamashita Asymmetric cell division is utilized by a broad range of cell types to generate two daughter cells with distinct cell fates. In stem cell populations asymmetric cell division is believed to be crucial for maintaining tissue homeostasis, failure of which can lead...

... ) Competing interests The authors declare no competing financial interests. 24 3 2014 12 5 2014 © 2014. Published by The Company of Biologists Ltd 2014 Asymmetric cell division TOE-2 Apoptosis Programmed cell death Cell fate Neuroblast Cysteine proteases, called...