... understood. Previous reports indicate a role for microglia in regulating astrocyte density. This current work resolves the mechanism through which microglia facilitate astrocyte spatial patterning and superficial vascular bed formation in the neuroretina during development. Ablation of microglia increased...

...Maria Micaela Sartoretti; Carla A. Campetella; Guillermo M. Lanuza ABSTRACT Significant progress has been made in elucidating the basic principles that govern neuronal specification in the developing central nervous system. In contrast, much less is known about the origin of astrocytic diversity...

...Françoise Helmbacher ABSTRACT Angiogenesis is a stepwise process leading to blood vessel formation. In the vertebrate retina, endothelial cells are guided by astrocytes migrating along the inner surface, and the two processes are coupled by a tightly regulated cross-talks between the two cell types...

... ON and OFF circuits in the inner retina . J. Neurosci.   20 , 7672 - 7681 . 10.1523/JNEUROSCI.20-20-07672.2000 Bayraktar , O. A. , Fuentealba , L. C. , Alvarez-Buylla , A. and Rowitch , D. H. ( 2014 ). Astrocyte development and heterogeneity . Cold Spring Harb. Perspect Biol.   7...

...Grégory Ghézali; Charles-Félix Calvo; Laure-Elise Pillet; Flora Llense; Pascal Ezan; Ulrike Pannasch; Alexis-Pierre Bemelmans; Sandrine Etienne Manneville; Nathalie Rouach ABSTRACT Astrocytes undergo intense morphological maturation during development, changing from individual sparsely branched...

... the liver. However, its role in the brain remains unclear. Here, we provide evidence for YAP regulation of mouse neocortical astrocytic differentiation and proliferation. YAP was undetectable in neurons, but selectively expressed in neural stem cells (NSCs) and astrocytes. YAP in NSCs was required...

... studies suggesting an important requirement for Shh FP in specifying oligodendrocyte cell fates via repression of Gli3 in progenitors. Our studies also uncover a connection between embryonic Shh signaling and astrocyte-mediated reactive gliosis in adults, raising the possibility that this pathway...

...Susumu Sakimoto; Hiroyasu Kidoya; Hisamichi Naito; Motohiro Kamei; Hirokazu Sakaguchi; Nobuhito Goda; Akiyoshi Fukamizu; Kohji Nishida; Nobuyuki Takakura Interactions between astrocytes and endothelial cells (ECs) are crucial for retinal vascular formation. Astrocytes induce migration...

... postnatal periods, radial glial cells in various ventricular zones of the brain differentiate into ependymal cells and astrocytes. However, mechanisms that drive this time- and cell-specific differentiation remain largely unknown. Here, we show that expression of the forkhead transcription factor FoxJ1...

... signalling. Dbx-expressing precursors also generate astrocytes and interneurons, but do not contribute to the ependymal layer of the postnatal spinal cord. * Author for correspondence (e-mail: [email protected] ) 10 2 2005 ©2005. 2005 Dbx Cre Spinal cord Radial glia Neurons...

...Heloise West; William D. Richardson; Marcus Fruttiger Development of the retinal vasculature is controlled by a hierarchy of interactions among retinal neurons, astrocytes and blood vessels. Retinal neurons release platelet-derived growth factor (PDGFA) to stimulate proliferation of astrocytes...

... mutant animals, which leads to poor intrauterine nutrition but allows fetuses to continue to term. Fetal bone volume is reduced greater than three-fold and the number of osteoclasts is increased six-fold, resulting in severe osteopenia of perinatal bone. Astrocyte numbers are reduced in the spinal cord...

...Robert H. Miller; Vilma Szigeti Summary Within the mammalian CNS, astrocytes appear to be a heterogeneous class of cells. To assay the number of distinct types of astrocytes in the rat spinal cord, cell lineage and phenotypic analyses were carried out on cultures from newborn rat spinal cord...

... vessels and accessory astrocytes, express neurothelin. Here we demonstrate that during chick brain development initially neurothelin is expressed probably in all neuroblasts. With proceeding cytodifferentiation, such as vascularization and gliogenesis, brain neurons become neurothelin negative...