... restricted, stroma-derived signaling molecule, netrin 1 (Ntn1), as a regulator of renal vascular patterning in mice. Stromal progenitor (SP)-specific ablation of Ntn1 ( Ntn1 SPKO ) resulted in smaller kidneys with fewer glomeruli, as well as profound defects of the renal artery and transient blood flow...

... in zebrafish . PLoS ONE 12 , e0178854 . 10.1371/journal.pone.0178854 Bussmann , J. , Wolfe , S. A. and Siekmann , A. F. ( 2011 ). Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling . Development 138 , 1717...

...Ilse Geudens; Baptiste Coxam; Silvanus Alt; Véronique Gebala; Anne-Clémence Vion; Katja Meier; Andre Rosa; Holger Gerhardt ABSTRACT How developing vascular networks acquire the right balance of arteries, veins and lymphatic vessels to efficiently supply and drain tissues is poorly understood...

...-Merker; Benjamin Hogan; Monica Beltrame; Sarah De Val; Mathias Francois Arterial specification and differentiation are influenced by a number of regulatory pathways. While it is known that the Vegfa-Notch cascade plays a central role, the transcriptional hierarchy controlling arterial specification has...

... and angiogenesis proceed normally in these mutants, demonstrating that the membrane-anchored extracellular domain is sufficient for vessel growth. By contrast, the NRP1 cytoplasmic domain is required for normal arteriovenous patterning, because arteries and veins crossed each other at an abnormally high frequency...

...Jayoung Choi; Kevin Mouillesseaux; Zhiming Wang; Hannah D. G. Fiji; Sape S. Kinderman; Georg W. Otto; Robert Geisler; Ohyun Kwon; Jau-Nian Chen Arterial and venous endothelial cells exhibit distinct molecular characteristics at early developmental stages. These lineage-specific molecular programs...

...Nathan D. Lawson; Nico Scheer; Van N. Pham; Cheol-Hee Kim; Ajay B. Chitnis; Jose A. Campos-Ortega; Brant M. Weinstein Recent evidence indicates that acquisition of artery or vein identity during vascular development is governed, in part, by genetic mechanisms. The artery-specific expression...

...Delphine Moyon; Luc Pardanaud; Li Yuan; Christiane Bréant; Anne Eichmann Remodeling of the primary vascular system of the embryo into arteries and veins has long been thought to depend largely on the influence of hemodynamic forces. This view was recently challenged by the discovery of several...