...Koichi Hasegawa; Takeshi K. Matsui; Junpei Kondo; Ken-ichiro Kuwako ABSTRACT During neural development, the actin filament network must be precisely regulated to form elaborate neurite structures. N-WASP tightly controls actin polymerization dynamics by activating an actin nucleator Arp2/3. However...

...Vassilis Papalazarou; Karthic Swaminathan; Farah Jaber-Hijazi; Heather Spence; Ines Lahmann; Colin Nixon; Manuel Salmeron-Sanchez; Hans-Henning Arnold; Klemens Rottner; Laura M. Machesky ABSTRACT The Arp2/3 complex is essential for the assembly of branched filamentous actin, but its role...

... with genetic analysis and electron tomography, we have identified the Actin-related protein (Arp) 2/3 complex as the major actin nucleator involved in the initiation of dendrite branchlet formation, under the control of the activator WAVE and of the small GTPase Rac1. Transient recruitment of an Arp2/3...

...Raymond Liu; Maria Teresa Abreu-Blanco; Kevin C. Barry; Elena V. Linardopoulou; Gregory E. Osborn; Susan M. Parkhurst Wiskott-Aldrich Syndrome (WAS) family proteins are Arp2/3 activators that mediate the branched-actin network formation required for cytoskeletal remodeling, intracellular transport...

... to enlarged foci that do not dissolve,consistent with the observed block in fusion. Kette is required to positively regulate SCAR/WAVE, which in turn activates the Arp2/3 complex. Mutants in SCAR and Arp2/3 have a fusion block and foci phenotype,suggesting that Kette-SCAR-Arp2/3 participate in an actin...

... within this group encode homologs of ARP2/3 subunits. In addition to trichome distortion, ARP2/3 subunit mutants have reduced shoot fresh weight and widespread defects in epidermal cell-cell adhesion. The precise cellular function of plant ARP2/3, and the means by which it is regulated, is not known...