...: Phosphorylations of the conserved serine cluster in the Drosophila E-Cadherin intracellular tail are quantitatively rather than site specifically required for its function in adherens junction formation. DE-Cadherin β-Catenin Shotgun Armadillo α-Catenin Adherens junctions Apical-basal polarity...

.... This mechanism is distinct from that in Drosophila. Flour beetle Armadillo Actin Time-lapse movie Parental RNAi Transient protein expression In most insects, the nuclei of the fertilized egg divide multiple times and move to the cortex before cellularization starts. During cellularization...

... embryogenesis. Girdin GIV Epithelial tissues Epithelial morphogenesis Cell-cell adhesion E-cadherin Armadillo Drosophila melanogaster Cell motility plays a fundamental role during animal development and is essential for tissue homeostasis ( Friedl and Gilmour, 2009 ). The cytoskeletal...

...Linh Thuong Vuong; Bibhash Mukhopadhyay; Kwang-Wook Choi Wingless (Wg)/Wnt signaling is fundamental in metazoan development. Armadillo (Arm)/β-catenin and Dishevelled (Dsh) are key components of Wnt signal transduction. Recent studies suggest that intracellular trafficking of Wnt signaling...

... of Wingless ( Drosophila Wnt) pathway activity in a functional screen for Drosophila miRNAs. We demonstrate that miR-310/13 can modulate Armadillo (Arm; Drosophila β-catenin) expression and activity by directly targeting the 3′-UTRs of arm and pangolin ( Drosophila TCF) in vivo . Notably, the miR-310/13...

... important processes such as proliferation, polarity and the specification of cell fates. Upon activation of the Wg/Wnt signaling pathway, Armadillo (Arm)/β-catenin is stabilized and interacts with the TCF family of transcription factors, which in turn activate Wnt target genes. We show here that Arm...

... transcription of the E-cadherin gene through the activation of Armadillo and TCF. This TCF-dependent pathway was essential for the maintenance of E-cadherin expression and for tissue integrity under conditions of high Src activity. Our data suggest that the two opposing outcomes of Src activation on E-cadherin...

...Hassina Benchabane; Edward G. Hughes; Carter M. Takacs; Jason R. Baird; Yashi Ahmed The mechanisms by which the Wingless (Wg) morphogen modulates the activity of the transcriptional activator Armadillo (Arm) to elicit precise,concentration-dependent cellular responses remain uncertain. Arm...

.../oncogenic form of Armadillo/β-catenin. This activity of Notch is independent of that induced upon cleavage of its intracellular domain and which mediates transcription through Su(H)/CBF1. The modulatory function of Notch described here, contributes to the establishment of a robust threshold for Wnt...

..., 2003 ). Altogether, these observations indicate that Dpp is not the only effector of Wingless during DC and indicates that Wingless signalling via Armadillo controls genes that act either in parallel or together with those regulated by JNK and Dpp. Expression of Wingless from the amnioserosa...

.../GSK3β to enhance the degradation of Armadillo (Arm), which causes downregulation of Wg signaling. In non-DV cells, Ubx inhibits event(s) downstream of Arm, but upstream of Vg autoregulation. Repression of Vg at multiple levels appears to be crucial for Ubx -mediated specification of the haltere fate...

...David S. Parker; Jemileh Jemison; Kenneth M. Cadigan The secreted glycoprotein Wingless (Wg) acts through a conserved signaling pathway to regulate target gene expression. Wg signaling causes nuclear translocation of Armadillo, the fly β-catenin, which then complexes with the DNA-binding protein...

...Nicholas S. Tolwinski; Eric Wieschaus Drosophila melanogaster Armadillo plays two distinct roles during development. It is a component of adherens junctions, and functions as a transcriptional activator in response to Wingless signaling. In the current model, Wingless signal causes stabilization...

... required for all these tracheal functions. However, the artificial overexpression of wingless in tracheal cells mimics the overexpression of a constitutively activated armadillo protein. The results suggest that another gene product, possibly a WNT, could help to trigger the wingless cascade...

... during dorsal closure, while Wingless signaling regulates segmental patterning of the larval cuticle via Armadillo. wingless or armadillo mutant embryos secrete a lawn of ventral denticles; armadillo mutants also exhibit dorsal closure defects. We found that mutations in puckered , a phosphatase...

...Rachel T. Cox; Li-Mei Pai; Jeffrey R. Miller; Sandra Orsulic; Joel Stein; Carol Ann McCormick; Yara Audeh; Wei Wang; Randall T. Moon; Mark Peifer ABSTRACT Drosophila Armadillo and its vertebrate homolog β-catenin are key effectors of Wingless/Wnt signaling. In the current model, Wingless/Wnt signal...

...Li-Mei Pai; Sandra Orsulic; Amy Bejsovec; Mark Peifer ABSTRACT Drosophila Armadillo and its vertebrate homolog β-catenin play essential roles both in the transduction of Wingless/Wnt cell-cell signals and in the function of cell-cell adherens junctions. Wingless and Wnts direct numerous cell fate...

...C. Wylie; M. Kofron; C. Payne; R. Anderson; M. Hosobuchi; E. Joseph; J. Heasman ABSTRACT In previous work, we demonstrated that maternally encoded β-catenin, the vertebrate homolog of armadillo, is required for formation of dorsal axial structures in early Xenopus embryos (Heasman, J., Crawford...

...Xiang Yu; Stefan Hoppler; Salih Eresh; Mariann Bienz ABSTRACT dishevelled, shaggy / zeste-white 3 and armadillo are required for transmission of the wingless signal in the Drosophila epidermis. We show that these genes act in the same epistatic order in the embryonic midgut to transmit the wingless...

...Mark Peifer; Dari Sweeton; Michael Casey; Eric Wieschaus ABSTRACT wingless/wnt-1 signaling directs cell fate during development. Genetic analysis in Drosophila identified genes that may encode components of the wingless signal transduction system. Drosophila Armadillo, homolog of vertebrate β...