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Keywords: Argos
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Journal Articles
Journal: Development
Development (2009) 136 (17): 2903–2911.
Published: 1 September 2009
... provided by the intracellular inhibitors of EGFR signaling, Kekkon-1 and Sprouty, control the number and position of Broad-expressing cells and in this way influence eggshell morphology. Later in oogenesis, the gradient of EGFR activation is split into two smaller domains in a process that depends on Argos...
Journal Articles
Journal: Development
Development (2003) 130 (22): 5401–5412.
Published: 15 November 2003
... Patterning Ommatidial rotation Adhesion Epidermal growth factor receptor spitz keren scabrous nemo roulette argos Development of complex organisms requires tissues to undergo significant morphogenesis and remodelling. One example of such a process occurs in the Drosophila eye...
Journal Articles
Journal: Development
Development (2003) 130 (22): 5413–5423.
Published: 15 November 2003
... the associated 90° rotation process. One of the few rotation-specific mutations known is roulette ( rlt ) in which ommatidia rotate to a random degree, often more than 90°. Here we show that rlt is a rotation-specific allele of the inhibitory Egfr ligand Argos and that modulation of Egfr activity shows defects...
Journal Articles
Journal: Development
Development (1998) 125 (23): 4777–4790.
Published: 1 December 1998
... appear to signal through Rhomboid and Vein to create a patterned array of ‘proneural clusters’ which contain high levels of phosphorylated ERKA and the bHLH protein Atonal. Finally, secretion by the proneural clusters of Argos represses DER activity in less mature regions to create a new pattern of R8s...
Journal Articles
Journal: Development
Development (1997) 124 (19): 3871–3880.
Published: 1 October 1997
... cells covering the oocyte expressed λtop. The expression of genes known to respond to top/Egfr activation, argos ( aos ), kekkon1 ( kek 1 ) and rhomboid ( rho ), was also expanded in the presence of the λtop construct. When λtop was expressed in all the follicle cells covering the oocyte, kek 1...
Journal Articles
Journal: Development
Development (1997) 124 (19): 3787–3796.
Published: 1 October 1997
... of function in genes of the spitz group or Drosophila EGF receptor ( DER ) pathway. Argos, a secreted molecule with an atypical EGF motif, is postulated to function as a DER antagonist. In this work, we assess the role of argos in the determination of midline glia cell number. Although all midline glia...
Journal Articles
Journal: Development
Development (1997) 124 (5): 1045–1053.
Published: 1 March 1997
... COPs are determined by the action of the proneural gene atonal and neurogenic genes. Subsequently, these five COPs start to express the rho gene, and rho activates the DER-signaling pathway in neighboring cells and induces argos expression. Three of these argos -expressing cells differentiate...
Journal Articles
Journal: Development
Development (1997) 124 (2): 261–270.
Published: 15 January 1997
... by the specific signal that induces it, but is instead a function of the state of the cell when it receives the signal. DER signalling is activated by the ligand, Spitz, and inhibited by the secreted protein, Argos. Spitz is initially produced by the central cells in the ommatidium and diffuses over a small...
Journal Articles
Journal: Development
Development (1996) 122 (1): 223–230.
Published: 1 January 1996
...Myriam Golembo; Ronen Schweitzer; Matthew Freeman; Ben-Zion Shilo ABSTRACT Argos is a secreted molecule with an atypical EGF motif. It was recently shown to function as an inhibitor of the signaling triggered by the Drosophila EGF receptor (DER). In this work, we determine the contribution of Argos...
Journal Articles
Journal: Development
Development (1994) 120 (8): 2297–2304.
Published: 1 August 1994
...Matthew Freeman ABSTRACT I have examined the effects on cells in the developing eye of over-expressing the argos gene. Transgenic flies carrying argos expressed under hsp70 and sevenless control sequences were analysed. All cell types in the developing eye (except bristles) are sensitive to argos...