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Development (2004) 131 (13): 3107–3120.
Published: 1 July 2004
...Jose Ignacio Pueyo; Juan Pablo Couso Proximodistal patterning in Drosophila requires division of the developing leg into increasingly smaller, discrete domains of gene function. The LIM-HOM transcription factors apterous ( ap ) and Lim1 (also known as dlim1 ), and the homeobox genes Bar...
Development (2004) 131 (2): 285–298.
Published: 15 January 2004
... for the development of the Drosophila wing, as well as vertebrate limbs. Here, we show that a 794 bp cis-regulatory element located in the 3′ region of the Ser gene can recapitulate the dynamic patterns of endogenous Ser expression during wing development. Using this enhancer element,we demonstrate that Apterous (Ap...
Development (2003) 130 (9): 1915–1925.
Published: 1 May 2003
... , Ssdp is expressed in the developing nervous system and imaginal tissues, and it is capable of modifying the in vivo activity of complexes comprised of Chip and the LIM-homeodomain protein Apterous. Null mutations of the ssdp gene are cell-lethal in clones of cells within the developing wing disc...
Development (2002) 129 (6): 1357–1368.
Published: 15 March 2002
... of the Drosophila Epidermal Growth Factor Receptor (EGFR). We show that EGFR signaling is necessary and sufficient to activate apterous ( ap ) expression, thereby segregating the wing disc into D ( ap -ON) and V ( ap -OFF) compartments. Similarly, we demonstrate that EGFR signaling directs the expression...
Development (2001) 128 (22): 4615–4622.
Published: 15 November 2001
...Ulrich Weihe; Marco Milán; Stephen M. Cohen Apterous is a LIM-homeodomain protein that confers dorsal compartment identity in Drosophila wing development. Apterous activity requires formation of a complex with a co-factor, Chip/dLDB. Apterous activity is regulated during wing development by dLMO...
Development (2001) 128 (17): 3263–3268.
Published: 1 September 2001
...Marco Milán; Ulrich Weihe; Stanley Tiong; Welcome Bender; Stephen M. Cohen Drosophila limbs develop from imaginal discs that are subdivided into compartments. Dorsal-ventral subdivision of the wing imaginal disc depends on apterous activity in dorsal cells. Apterous protein is expressed in dorsal...