...Lauren S. Phipps; Lindsey Marshall; Karel Dorey; Enrique Amaya ABSTRACT Understanding how to promote organ and appendage regeneration is a key goal of regenerative medicine. The frog, Xenopus , can achieve both scar-free healing and tissue regeneration during its larval stages, although...

...Sergio Córdoba; David Requena; Aurelie Jory; Almudena Saiz; Carlos Estella The appendages of arthropods and vertebrates are not homologous structures, although the underlying genetic mechanisms that pattern them are highly conserved. Members of the Sp family of transcription factors are expressed...

... three tarsal rings are Spineless-dependent. Thus bric a brac is regulated differentially even within a single appendage type. The restriction of bric a brac expression to the distal portion of the Distal-less domain is a consequence of negative regulation by distinct sets of genes in different limb...

...Ginés Morata; Ernesto Sánchez-Herrero ABSTRACT During evolution, many animal groups have developed specialised outgrowths of the body wall, limbs or appendages. The type of appendage depends on the identity of the segment where they appear, indicating that the Hox genes contribute to appendage...