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Keywords: Apoptosis
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Journal Articles
Journal: Development
Development (2022) 149 (10): dev200181.
Published: 26 May 2022
... shelves and must be removed to allow mesenchymal confluence. Abundant apoptosis and cell extrusion support their importance in MES removal. However, genetically disrupting the intrinsic apoptotic regulators BAX and BAK within the MES results in complete loss of cell death and cell extrusion...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (24): dev199762.
Published: 15 December 2021
... independently of Netrin to directly regulate transcription during axon guidance in Drosophila . In other contexts, Dcc acts as a tumor suppressor by directly promoting apoptosis. In this study, we report that Fra is required in the Drosophila female germline for the progression of egg chambers through mid...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (3): dev188276.
Published: 8 February 2021
... is largely unknown. Here, we show that Exosc10, a RNA exonuclease subunit of the RNA exosome complex, is indispensable for forebrain development. We report that cortical cells undergo overt apoptosis, culminating in cortical agenesis upon conditional deletion of Exosc10 in mouse cortex. Mechanistically...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev191882.
Published: 24 July 2020
.... ( 2009 ). The insect caspases . Apoptosis   14 , 247 - 256 . 10.1007/s10495-009-0322-1 Cordes , S. , Frank , C. A. and Garriga , G. ( 2006 ). The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions . Development...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (13): dev184838.
Published: 3 July 2020
... that is suppressed by Hx. Interestingly, GCs with lower expression of GDF9/BMP15 receptors appear to be more sensitive to Hx-induced G2/M arrest and become easily detached from the follicular wall. Importantly, Hx-mediated inhibition of G2/M progression instigates GC apoptosis, which is ameliorated in the presence...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (1): dev182295.
Published: 13 January 2020
... analysis implicates p53 signaling; moreover, p53 ablation in Magoh haploinsufficient progenitors rescues apoptosis, completely recovering interneuron number. In striking contrast, in Magoh homozygotes, p53 loss fails to rescue interneuron number and mitotic delay, further implicating mitotic defects...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (16): dev175158.
Published: 22 August 2019
...)-expressing neuroblasts undergo apoptosis in females whereas their male counterparts proliferate and give rise to serotonergic neurons crucial for adult mating behaviour. Our study demonstrates that the female-specific isoform of Dsx collaborates with Hox gene Abdominal-B ( Abd-B ) to bring about...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev173286.
Published: 21 June 2019
... flattening, eye misshaping and increased apoptosis than yap1 −/− single mutants, thus revealing overlapping gene functions. Our results indicate that, despite its divergent transactivation domain, Yap1b cooperates with Yap1 to regulate cell survival and tissue morphogenesis during early development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev170753.
Published: 1 February 2019
... for cardiomyocyte development in mouse but contrasting Myc levels between neighbouring cells is involved in elimination of unfit cardiomyocytes during heart development by cell competition. Heart development Transcription factor Proliferation Apoptosis Cell competition Mouse Myc transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev164046.
Published: 24 October 2018
... kinase (LTK), an ALK-type receptor tyrosine kinase, is expressed by neural crest cells during early migratory stages in chicken embryos. Loss of LTK in the cranial neural crest impairs migration and results in increased levels of apoptosis. Conversely, midkine, previously proposed as a ligand for ALK...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev160127.
Published: 11 June 2018
... intermediate neural progenitors (INPs). Distinct type II neuroblasts produce different characteristic sets of glia. A single INP can make both astrocyte-like and ensheathing glia, which co-occupy a relatively restrictive subdomain. Blocking apoptosis uncovers further lineage distinctions in the specification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev158139.
Published: 8 January 2018
...% of immature thymocytes are eliminated via apoptosis. It is known that mutation of Zeb1 , one of the retinoblastoma 1 (Rb1) target genes, results in a decrease in the number of immature T cells in mice. E2F1, an RB1-interacting protein, has been shown to regulate mature T cell development by interfering...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154468.
Published: 3 January 2018
... and undergo apoptosis, thereby disrupting endocrine and acinar cell differentiation, resulting in pancreatic agenesis. Rescue experiments implicate the Asna1 ATPase activity and a CXXC di-cysteine motif in ensuring Golgi integrity, syntaxin 5 localization and MPC survival. Ex vivo inhibition of retrograde...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (24): 4645–4657.
Published: 15 December 2017
...Katsuki Mukaigasa; Chie Sakuma; Tomoaki Okada; Shunsaku Homma; Takako Shimada; Keiji Nishiyama; Noboru Sato; Hiroyuki Yaginuma In the developing chick embryo, a certain population of motor neurons (MNs) in the non-limb-innervating cervical spinal cord undergoes apoptosis between embryonic days 4...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (20): 3840–3846.
Published: 15 October 2017
... post-acquisition processing. They overcome the limitations of other apoptosis detection methods developed so far and, notably, they can be combined with any kind of fluorophore. * These authors contributed equally to this work ‡ Authors for correspondence ( magali.suzanne@univ-tlse3.fr...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3602–3611.
Published: 1 October 2017
... neural progenitors. Live imaging and immunolocalizations indicate that Sp-SoxC-expressing cells divide to produce pairs of adjacent cells expressing GFP. Over an interval of about 6 h, one cell fragments, undergoes apoptosis and expresses high levels of activated Caspase3. A Notch reporter indicates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3349–3360.
Published: 15 September 2017
... gain-of-function approaches, we found that overexpression of Ntn1 in the chick otic vesicle prevented canal fusion by inhibiting apoptosis. In contrast, ectopic expression of the same chicken Ntn1 in the mouse otic vesicle, where apoptosis is less prominent, resulted in canal truncation. These findings...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (11): 1988–1996.
Published: 1 June 2017
... and eliminated by apoptosis, which probably causes the observed atrophy of the seminiferous tubules. Our data on Mad2 +/+ Mlh1 −/− mice is consistent with a previous Mlh1 −/− mice study ( Eaker et al., 2002 ), and reduced MAD2 level (i.e. Mad2 +/− Mlh1 −/− males) did not provide any detectable rescue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (5): 808–819.
Published: 1 March 2017
... differentiated cells to the gut epithelium, without preceding cell loss, leads to enterocyte overcrowding. Finally, we show that a couple of days later, the correct density of enterocytes is promptly restored by means of a wave of apoptosis involving Hippo signaling and preferential removal of old enterocytes...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (1): 128–138.
Published: 1 January 2017
... maturation has been extensively investigated and its regulatory mechanisms are well documented. However, translational regulation of maternal RNA in early oogenesis is largely unexplored. In this study, we generated zebrafish zar1 mutants that result in early oocyte apoptosis and fully penetrant male...
Includes: Supplementary data