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Keywords: Apical-basal polarity
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Journal Articles
Journal: Development
Development (2020) 147 (15): dev186593.
Published: 07 August 2020
...Guilherme Ventura; Sofia Moreira; André Barros-Carvalho; Mariana Osswald; Eurico Morais-de-Sá ABSTRACT Apical-basal polarity underpins the formation of epithelial barriers that are crucial for metazoan physiology. Although apical-basal polarity is long known to require the basolateral determinants...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev180976.
Published: 21 November 2019
...Teresa T. Bonello; Wangsun Choi; Mark Peifer ABSTRACT Apical-basal polarity is a fundamental property of animal tissues. Drosophila embryos provide an outstanding model for defining mechanisms that initiate and maintain polarity. Polarity is initiated during cellularization, when cell-cell adherens...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev162792.
Published: 14 September 2018
... by the apical-basal polarity of the barbule plate keratinocytes, which is in turn regulated by the Par3/aPKC machinery. Our data elucidate a new mechanism through which the global Wnt signaling gradient is interpreted locally to construct complex spatial forms. In an effort to systematically dissect gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev158444.
Published: 02 May 2018
...Heng Wang; Zhiqian Qiu; Zehao Xu; Samuel John Chen; Jun Luo; Xiaobo Wang; Jiong Chen ABSTRACT Apical-basal polarity is a hallmark of epithelia and needs to be remodeled when epithelial cells undergo morphogenetic cell movements. Here, we analyze border cells in the Drosophila ovary to address how...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1242–1248.
Published: 01 April 2017
...-Catenin. In addition, several phospho-mutations dramatically reduced the biosynthetic turnover rate of DE-Cad during apical-basal polarization, and such biosynthetically stable DE-Cad mutants specifically rescued the polarity defects in embryonic epithelia lacking the polarity proteins Stardust and Crumbs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3692–3703.
Published: 01 November 2015
... are physically attached to each other and retain some degree of apical-basal polarity during the migratory phase. Although much is known about direction sensing, how polarity is regulated in multicellular movement remains unclear. Here we report the role of the protein kinase Pak3 in maintaining apical-basal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (21): 4121–4126.
Published: 01 November 2014
... ) Competing interests The authors declare no competing financial interests. 18 3 2014 1 9 2014 © 2014. Published by The Company of Biologists Ltd 2014 We next asked where along the proximal-distal sprout axis apical-basal polarity is present. We analyzed HUVEC sprouts in distal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 2984–2992.
Published: 01 August 2014
...-basal polarity Oskar Although the nature of this polarising signal is unknown, it induces a very similar distribution of PAR proteins to that in the C. elegans zygote. Bazooka (Baz; Drosophila Par-3), Par-6 and aPKC disappear from the posterior cortex of the oocyte and mark its anterior...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (16): 2891–2896.
Published: 15 August 2012
... complex Crumbs-Stardust (Pals1 or Mpp5 in mammalian cells) to establish apical-basal polarity. However, owing to the lack of suitable genetic mutants, the exact in vivo function of Patj in regulating apical-basal polarity and development remains to be elucidated. Here, we generated molecularly defined...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (14): 3021–3031.
Published: 15 July 2011
... for correspondence ( jvincen@nimr.mrc.ac.uk ) Competing interests statement The authors declare no competing financial interests. 10 5 2011 © 2011. 2011 Epithelial integrity JNK (Basket) Reaper Apical-basal polarity Apoptosis Drosophila Apoptosis is an integral part...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4297–4306.
Published: 01 December 2007
... layers of the epidermis and results in altered cell fates. We expect that the same pathway may control asymmetric divisions of stem/progenitor cells in other epithelial tissues and organs. Despite growing experimental evidence related to the establishment of the apical-basal polarity, how cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (2): 387–397.
Published: 15 January 2002
... Apical-basal polarity Gastrulation Ingression Morphogenesis Cell fate Cell shape Non-muscle myosin LIT-1 HMR-1 NMY-2 PAR-2 PAR-3 PAR-6 C. elegans Numerous studies on C. elegans embryos have revealed the basic strategies that establish the anterior-posterior and dorsal-ventral...