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Keywords: Apical endfoot
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Journal Articles
Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates
Available to PurchaseJun Hatakeyama, Yoshio Wakamatsu, Akira Nagafuchi, Ryoichiro Kageyama, Ryuichi Shigemoto, Kenji Shimamura
Journal:
Development
Development (2014) 141 (8): 1671–1682.
Published: 15 April 2014
..., and these proteins physically interact with ZO-1, a constituent of the AJ. Furthermore, live imaging of a fluorescently tagged Notch1 demonstrated its trafficking from the apical endfoot to the nucleus upon cleavage. Our results identified the apical endfoot as the central site of active Notch signaling to securely...
Includes: Supplementary data
